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Journal ArticleDOI

Hydrogels for tissue engineering.

Kuen Yong Lee, +1 more
- 31 May 2001 - 
- Vol. 101, Iss: 7, pp 1869-1879
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This article is published in Chemical Reviews.The article was published on 2001-05-31. It has received 4511 citations till now. The article focuses on the topics: Self-healing hydrogels.

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Designing Injectable, Covalently Cross-Linked Hydrogels for Biomedical Applications

TL;DR: The design rules for the effective engineering of injectable, in situ gelling hydrogels in the context of these design guidelines are outlined, noting the outstanding challenges associated with the use of this class of hydrogel in vivo.
Journal ArticleDOI

Vocal fold tissue repair in vivo using a synthetic extracellular matrix.

TL;DR: Carbylan-GSX containing 5% w/w gelatin showed the most promise as a scaffold material for vocal fold tissue regeneration and significantly improved tissue elasticity and viscosity.
Journal ArticleDOI

Nanocarrier-based systems for targeted and site specific therapeutic delivery.

TL;DR: The present review describes major advantages and limitations of organic and inorganic nanocarriers or living cell-based drug and nucleic acid delivery systems.
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Nanohybrid hydrogels of laponite: PVA-Alginate as a potential wound healing material

TL;DR: The synergistic effects of the nanohybrid hydrogels such as superior mechanical properties, adjustable degradation rate and admirable biocompatibility and hemolysis make them a desirable candidate for wound healing process.
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A microgel construction kit for bioorthogonal encapsulation and pH-controlled release of living cells.

TL;DR: PH-Cleavable cell-laden microgels with excellent long-term viabilities were fabricated by combining bioorthogonal strain-promoted azide-alkyne cycloaddition and droplet-based microfluidics, allowing the cells to be studied and manipulated during the encapsulation and then be isolated and harvested by decomposition of the microgel scaffolds.
References
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Journal Article

Tissue engineering : Frontiers in biotechnology

R. Langer, +1 more
- 01 Jan 1993 - 
Journal ArticleDOI

Solution Properties of Poly(N-isopropylacrylamide)

TL;DR: In this paper, a lower critical solution temperature of poly(N-isopropyl acrylamide was found to be due to an entropy effect, which was attributed to the formation of nonpolar and intermolecular hydrogen bonds.
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Polymeric Systems for Controlled Drug Release

TL;DR: Kevin Shakesheff investigates new methods of engineering polymer surfaces and the application of these engineered materials in drug delivery and tissue engineering.
Journal ArticleDOI

Alginate hydrogels as synthetic extracellular matrix materials

TL;DR: Alginate may prove to be an ideal material with which to confer specific cellular interactive properties, potentially allowing for the control of long-term gene expression of cells within these matrices.
Journal ArticleDOI

Biodegradable block copolymers as injectable drug-delivery systems

TL;DR: The synthesis of a thermosensitive, biodegradable hydrogel consisting of blocks of poly(ethylene oxide) and poly(L-lactic acid) and aqueous solutions of these copolymers exhibit temperature-dependent reversible gel–sol transitions.
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