Journal ArticleDOI
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
Vincenzo Bonifati,Vincenzo Bonifati,Patrizia Rizzu,Marijke J. van Baren,Onno Schaap,Guido J. Breedveld,Elmar Krieger,Marieke C. J. Dekker,Ferdinando Squitieri,Pablo Ibanez,Marijke Joosse,Jeroen W.F. van Dongen,Nicola Vanacore,Nicola Vanacore,John C. van Swieten,Alexis Brice,Giuseppe Meco,Cornelia M. van Duijn,Ben A. Oostra,Peter Heutink +19 more
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TLDR
It is shown that DJ-1 mutations are associated with PARK7, a monogenic form of human parkinsonism, and these findings indicate that loss ofDJ-1 function leads to neurodegeneration.Abstract:
The DJ-1 gene encodes a ubiquitous, highly conserved protein. Here, we show that DJ-1 mutations are associated with PARK7, a monogenic form of human parkinsonism. The function of the DJ-1 protein remains unknown, but evidence suggests its involvement in the oxidative stress response. Our findings indicate that loss of DJ-1 function leads to neurodegeneration. Elucidating the physiological role of DJ-1 protein may promote understanding of the mechanisms of brain neuronal maintenance and pathogenesis of Parkinson's disease.read more
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Understanding the relationship between brain gene expression and social behavior: Lessons from the honey bee
Amro Zayed,Gene E. Robinson +1 more
TL;DR: A linked series of studies that assayed changes in honey bee brain transcriptomes associated with natural and experimentally induced changes in behavioral state demonstrate that brain gene expression is closely linked with behavior, that changes in brain geneexpression mediate changes in behavior, and that the association between specific genes and behavior exists over multiple timescales, from physiological to evolutionary.
Journal ArticleDOI
Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress
TL;DR: The results suggest that translocation of DJ-1 to mitochondria after oxidative stress is carried out in association with chaperones, and that L166P and M26I mutants found in PD patients were strongly associated with Hsp70 and CHIP compared to wild-type and otherDJ-1 mutants.
Journal ArticleDOI
Induction of Reactive Oxygen Species by Bisphenol A and Abrogation of Bisphenol A-Induced Cell Injury by DJ-1
TL;DR: DJ-1 was found to maintain the complex I activity against BPA-induced oxidative stress after the localization in mitochondria and showed a role in the prevention of mitochondrial injury-induced cell death.
Journal ArticleDOI
Genetic Mouse Models of Parkinsonism: Strengths and Limitations
TL;DR: The recent discovery of specific genes causing familial forms of PD has contributed to the development of novel genetic mouse models of PD, and a review discusses the validity, benefits, and limitations of these new models.
References
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