Journal ArticleDOI
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
Vincenzo Bonifati,Vincenzo Bonifati,Patrizia Rizzu,Marijke J. van Baren,Onno Schaap,Guido J. Breedveld,Elmar Krieger,Marieke C. J. Dekker,Ferdinando Squitieri,Pablo Ibanez,Marijke Joosse,Jeroen W.F. van Dongen,Nicola Vanacore,Nicola Vanacore,John C. van Swieten,Alexis Brice,Giuseppe Meco,Cornelia M. van Duijn,Ben A. Oostra,Peter Heutink +19 more
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TLDR
It is shown that DJ-1 mutations are associated with PARK7, a monogenic form of human parkinsonism, and these findings indicate that loss ofDJ-1 function leads to neurodegeneration.Abstract:
The DJ-1 gene encodes a ubiquitous, highly conserved protein. Here, we show that DJ-1 mutations are associated with PARK7, a monogenic form of human parkinsonism. The function of the DJ-1 protein remains unknown, but evidence suggests its involvement in the oxidative stress response. Our findings indicate that loss of DJ-1 function leads to neurodegeneration. Elucidating the physiological role of DJ-1 protein may promote understanding of the mechanisms of brain neuronal maintenance and pathogenesis of Parkinson's disease.read more
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Journal ArticleDOI
Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice.
Linan Chen,Barbara Cagniard,Tiffany A. Mathews,Sara R. Jones,Hyun Chul Koh,Yunmin Ding,Paul M. Carvey,Zaodung Ling,Un Jung Kang,Xiaoxi Zhuang +9 more
TL;DR: This article showed that DJ-1 deficiency led to age-dependent and task-dependent motoric behavioral deficits that are detectable by 5 months of age in 6-month and 11-month-old mice.
Journal ArticleDOI
Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures.
Linda D Mercer,Linda D Mercer,Belinda Louise Kelly,Belinda Louise Kelly,Malcolm K. Horne,Malcolm K. Horne,Philip M Beart,Philip M Beart +7 more
TL;DR: The neuroprotective abilities of flavonoids are demonstrated which are able to attenuate the apoptotic injury of mesencephalic DA neurones in Parkinsonism, suggesting that flavonoid could provide benefits along with other anti-oxidant therapies in Parkinson's disease.
Journal ArticleDOI
Genetics of Parkinson disease.
Nathan Pankratz,Tatiana Foroud +1 more
TL;DR: With the identification of mutations in particular genes and the likely role of additional genes that are important in PD risk-susceptibility, appropriate protocols must be developed so that accurate and informative genetic counseling can be offered to families in which one or more members has PD.
Journal ArticleDOI
Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration.
Carla R.A. Batista,Giovanni Freitas Gomes,Eduardo Candelario-Jalil,Bernd L. Fiebich,Antônio Carlos Pinheiro de Oliveira +4 more
TL;DR: The use of LPS in various models of neurodegeneration is reviewed as well as the neuroinflammatory mechanisms induced by this toxin that could underpin the pathological events linked to the Neurodegenerative process are discussed.
Journal ArticleDOI
Role of ubiquitylation in cellular membrane transport.
Olivier Staub,Daniela Rotin +1 more
TL;DR: The progress in understanding Ubiquitylation of membrane proteins and its role in endoplasmic reticulum-associated degradation is discussed.
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