Journal ArticleDOI
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
Vincenzo Bonifati,Vincenzo Bonifati,Patrizia Rizzu,Marijke J. van Baren,Onno Schaap,Guido J. Breedveld,Elmar Krieger,Marieke C. J. Dekker,Ferdinando Squitieri,Pablo Ibanez,Marijke Joosse,Jeroen W.F. van Dongen,Nicola Vanacore,Nicola Vanacore,John C. van Swieten,Alexis Brice,Giuseppe Meco,Cornelia M. van Duijn,Ben A. Oostra,Peter Heutink +19 more
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TLDR
It is shown that DJ-1 mutations are associated with PARK7, a monogenic form of human parkinsonism, and these findings indicate that loss ofDJ-1 function leads to neurodegeneration.Abstract:
The DJ-1 gene encodes a ubiquitous, highly conserved protein. Here, we show that DJ-1 mutations are associated with PARK7, a monogenic form of human parkinsonism. The function of the DJ-1 protein remains unknown, but evidence suggests its involvement in the oxidative stress response. Our findings indicate that loss of DJ-1 function leads to neurodegeneration. Elucidating the physiological role of DJ-1 protein may promote understanding of the mechanisms of brain neuronal maintenance and pathogenesis of Parkinson's disease.read more
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The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins?
TL;DR: Similarities between clinical and experimental findings, such as the role of pesticide exposure as a potential environmental risk factor, highlight the importance of a multidisciplinary approach to the aetiology of PD.
Journal ArticleDOI
Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studies.
Fernanda Martins Lopes,Rafael Schröder,da Frota Ml,Alfeu Zanotto-Filho,Carolina Beatriz Müller,André Simões Pires,Rosalva Thereza Meurer,Gabriela D. Colpo,Daniel Pens Gelain,Flávio Kapczinski,José Cláudio Fonseca Moreira,Fernandes Mda C,Fábio Klamt +12 more
TL;DR: The data suggest that SH-SY5Y cells differentiated by 7 days with the protocol described here represent a more suitable experimental model for studying the molecular and cellular mechanisms underlying the pathophysiology of PD.
Journal ArticleDOI
Multifunctional activities of green tea catechins in neuroprotection. Modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway.
Silvia Mandel,Yael Avramovich-Tirosh,Lydia Reznichenko,Hailin Zheng,Orly Weinreb,Tamar Amit,Moussa B.H. Youdim +6 more
TL;DR: This review will focus on the multifunctional properties of green tea and its major component (–)-epigallocatechin-3-gallate (EGCG) and their ability to induce neuroprotection and neurorescue in vitro and in vivo and their transitional metal chelating property and inhibition of oxidative stress.
Journal ArticleDOI
Loss of locus coeruleus neurons and reduced startle in parkin null mice
Rainer von Coelln,Bobby Thomas,Joseph M. Savitt,Kah-Leong Lim,Masayuki Sasaki,Ellen J. Hess,Valina L. Dawson,Ted M. Dawson +7 more
TL;DR: This mouse model will help gain a better understanding of parkin function and the mechanisms underlying parkin-associated PD, and there is a dramatic reduction of the norepinephrine-dependent startle response.
Journal ArticleDOI
Parkin disease: a phenotypic study of a large case series
Naheed L. Khan,Elizabeth Graham,Peter Critchley,Anette Schrag,Nicholas W. Wood,Andrew J. Lees,Kailash P. Bhatia,Niall Quinn +7 more
TL;DR: A number of clinical features that can be seen in parkin disease are emphasized: focal dystonia; early instability; freezing; festination or retropulsion; concurrent autonomic failure; dramatic response to anticholinergics; early or atypical L- dopa-induced dyskinesias; exquisite sensitivity to small doses of L-dopa; and recurrent psychosis.
References
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DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras.
Daisuke Nagakubo,Takahiro Taira,Hirotake Kitaura,Masako Ikeda,Katsuyuki Tamai,Sanae M.M. Iguchi-Ariga,Hiroyoshi Ariga +6 more
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