Journal ArticleDOI
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
Vincenzo Bonifati,Vincenzo Bonifati,Patrizia Rizzu,Marijke J. van Baren,Onno Schaap,Guido J. Breedveld,Elmar Krieger,Marieke C. J. Dekker,Ferdinando Squitieri,Pablo Ibanez,Marijke Joosse,Jeroen W.F. van Dongen,Nicola Vanacore,Nicola Vanacore,John C. van Swieten,Alexis Brice,Giuseppe Meco,Cornelia M. van Duijn,Ben A. Oostra,Peter Heutink +19 more
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TLDR
It is shown that DJ-1 mutations are associated with PARK7, a monogenic form of human parkinsonism, and these findings indicate that loss ofDJ-1 function leads to neurodegeneration.Abstract:
The DJ-1 gene encodes a ubiquitous, highly conserved protein. Here, we show that DJ-1 mutations are associated with PARK7, a monogenic form of human parkinsonism. The function of the DJ-1 protein remains unknown, but evidence suggests its involvement in the oxidative stress response. Our findings indicate that loss of DJ-1 function leads to neurodegeneration. Elucidating the physiological role of DJ-1 protein may promote understanding of the mechanisms of brain neuronal maintenance and pathogenesis of Parkinson's disease.read more
Citations
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Journal ArticleDOI
DJ-1 Enhances Cell Survival through the Binding of Cezanne, a Negative Regulator of NF-κB
R. Sean McNally,Beckley K. Davis,Casey M. Clements,Mary Ann Accavitti-Loper,Tak W. Mak,Jenny P.-Y. Ting +5 more
TL;DR: A novel pathway is described by which DJ-1 controls cell survival and possibly tumor progression via interaction with Cezanne, which is associated with a reduction in chemotherapeutic-induced cell death and poor prognosis in several cancers.
Journal ArticleDOI
Fluorescent probes for bioimaging of potential biomarkers in Parkinson's disease.
Liqian Gao,Liqian Gao,Wei Wang,Wei Wang,Xuan Wang,Fen Yang,Xie Liuxing,Jun Shen,Margaret A. Brimble,Qicai Xiao,Qicai Xiao,Shao Q. Yao +11 more
TL;DR: This review comprehensively summarize the design and working mechanisms of fluorescent probes along with their applications in the detection of various PD biomarkers and provides perspectives on how these limitations can be overcome to develop better fluorescent probes suitable for application in clinical trials in the future.
Journal ArticleDOI
Cellular Regulation of Amyloid Formation in Aging and Disease.
TL;DR: Different aspects of the involvement ofAmyloid-forming proteins in disease, mechanisms of toxicity, structural features, and biological functions of amyloids are reviewed, as well as the cellular mechanisms that modulate and regulate protein aggregation, including the presence of enhancers and suppressors of aggregation, are reviewed.
Journal ArticleDOI
Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains
Stéphanie Baulac,Hope Y. Lu,Jennifer Strahle,Ting Yang,Matthew S. Goldberg,Matthew S. Goldberg,Jie Shen,Michael G. Schlossmacher,Cynthia A. Lemere,Qun Lu,Weiming Xia +10 more
TL;DR: The results strongly suggest that DJ-1 expression is not necessary during zebra fish development but can be induced in zebrafish exposed to oxidative stress and is present in human AD brains.
Journal ArticleDOI
SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria
TL;DR: PINK1 forms a complex with SARM1 and TRAF6, which is important for stabilization of PINK1 and induction of mitophagy.
References
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Daisuke Nagakubo,Takahiro Taira,Hirotake Kitaura,Masako Ikeda,Katsuyuki Tamai,Sanae M.M. Iguchi-Ariga,Hiroyoshi Ariga +6 more
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