Nanomaterial-based delivery vehicles for therapeutic cancer vaccine development
Jie Liang,Xiao Zhao,Xiao Zhao +2 more
TLDR
In this article, the authors summarized the development of preclinical therapeutic cancer vaccines and the advancements of nanomaterial-based delivery vehicles for cancer immunotherapies, which provide the basis for a personalized vaccine delivery platform.Abstract:
Nanomaterial-based delivery vehicles such as lipid-based, polymer-based, inorganics-based, and bio-inspired vehicles often carry distinct and attractive advantages in the development of therapeutic cancer vaccines. Based on various delivery vehicles, specifically designed nanomaterials-based vaccines are highly advantageous in boosting therapeutic and prophylactic antitumor immunities. Specifically, therapeutic vaccines featuring unique properties have made major contributions to the enhancement of antigen immunogenicity, encapsulation efficiency, biocompatibility, and stability, as well as promoting antigen cross-presentation and specific CD8+ T cell responses. However, for clinical applications, tumor-associated antigen-derived vaccines could be an obstacle, involving immune tolerance and deficiency of tumor specificities, in achieving maximum therapeutic indices. However, when using bioinformatics predictions with emerging innovations of in silico tools, neoantigen-based therapeutic vaccines might become potent personalized vaccines for tumor treatments. In this review, we summarize the development of preclinical therapeutic cancer vaccines and the advancements of nanomaterial-based delivery vehicles for cancer immunotherapies, which provide the basis for a personalized vaccine delivery platform. Moreover, we review the existing challenges and future perspectives of nanomaterial-based personalized vaccines for novel tumor immunotherapies.read more
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Antigen Capture and Immune Modulation by Bacterial Outer Membrane Vesicles as In Situ Vaccine for Cancer Immunotherapy Post-Photothermal Therapy.
Yao Li,Kaiyue Zhang,Yao Wu,Yale Yue,Keman Cheng,Qingqing Feng,Xiaotu Ma,Jie Liang,Nana Ma,Guangna Liu,Guangjun Nie,Lei Ren,Xiaozheng Zhao +12 more
TL;DR: A promising in situ vaccine based on OMVs to facilitate immune-mediated tumor clearance after PTT through orchestrating antigen capture and immune modulation is presented.
Journal ArticleDOI
Nanocarriers based on bacterial membrane materials for cancer vaccine delivery
TL;DR: In this paper , two different types of nanocarriers based on bacterial membrane materials, which employ genetically engineered outer-membrane vesicles (OMVs), or hybrid membrane Vesicles containing bacterial cytoplasmic membrane, were developed for cancer vaccine delivery.
Journal ArticleDOI
Polymer-Based Nanosystems-A Versatile Delivery Approach.
TL;DR: In this paper, the authors review current and emerging drug delivery applications of both branched and linear, natural, and synthetic polymer nanostructures, focusing on their role in vaccine development.
Journal ArticleDOI
Engineered Bacterial Outer Membrane Vesicles as Controllable Two‐Way Adaptors to Activate Macrophage Phagocytosis for Improved Tumor Immunotherapy
Qingqing Feng,Xiaotu Ma,Keman Cheng,Guangna Liu,Yao Li,Yale Yue,Jie Liang,Lizhuo Zhang,Tianjiao Zhang,Xinwei Wang,Xiaoyu Gao,Guangjun Nie,Xiaozheng Zhao +12 more
TL;DR: An OMV‐based controllable two‐way adaptor is reported, in which a CD47 nanobody is fused onto OMV surface, with the outer surface coated with a polyethylene glycol (PEG) layer containing diselenide bonds (Peg/Se) to form PEG/Se@OMV‐CD47nb.
Journal ArticleDOI
Novel Strategies for Spinal Cord Regeneration
B. Costachescu,Adelina-Gabriela Niculescu,Marius Dabija,Raluca Ioana Teleanu,Alexandru Mihai Grumezescu,Lucian Eva +5 more
TL;DR: The present review aims to explore the most recent developments in SCI treatment and spinal cord repair, and briefly describes the characteristics of SCIs, followed by an extensive discussion on newly developed nanocarriers and relevant biomolecules for spinal cord regeneration.
References
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Chaotic Mixer for Microchannels
Abraham D. Stroock,Stephan K. W. Dertinger,Armand Ajdari,Igor Mezic,Howard A. Stone,George M. Whitesides +5 more
TL;DR: This work presents a passive method for mixing streams of steady pressure-driven flows in microchannels at low Reynolds number, and uses bas-relief structures on the floor of the channel that are easily fabricated with commonly used methods of planar lithography.
Journal ArticleDOI
Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Jayanth Panyam,Vinod Labhasetwar +1 more
TL;DR: Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed.