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Past, present and future: 30 years of HIV research.

Françoise Barré-Sinoussi, +2 more
- 01 Dec 2013 - 
- Vol. 11, Iss: 12, pp 877-883
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TLDR
A historical perspective is provided of some of the major milestones in HIV science, highlighting how translational research has affected treatment and prevention and the scientific challenges ahead in the search for a cure for HIV.
Abstract: 
This year marks the thirtieth anniversary of the publication of the study that first reported the isolation of HIV-1. In this Timeline article, we provide a historical perspective of some of the major milestones in HIV science, highlighting how translational research has affected treatment and prevention of HIV. Finally, we discuss some of the current research directions and the scientific challenges ahead, in particular in the search for a cure for HIV.

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Male circumcision for HIV prevention in young men in Kisumu, Kenya : a randomised controlled trial. Commentary

Marie-Louise Newell, +10 more
- 01 Jan 2007 - 
TL;DR: Male circumcision significantly reduces the risk of HIV acquisition in young men in Africa and should be integrated with other HIV preventive interventions and provided as expeditiously as possible.
Journal ArticleDOI

International AIDS Society global scientific strategy: towards an HIV cure 2016

Steven G. Deeks, +54 more
- 01 Aug 2016 - 
TL;DR: A group of international experts to develop a scientific strategy for research towards an HIV cure summarized the group's strategy in this Perspective.
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Dietary Selenium in Adjuvant Therapy of Viral and Bacterial Infections

Holger Steinbrenner, +4 more
- 01 Jan 2015 - 
TL;DR: A recent review as mentioned in this paper provides an up-to-date overview on selenium in infectious diseases caused by viruses (e.g., HIV, IAV, hepatitis C virus, poliovirus, West Nile virus) and bacteria (i.e., M. tuberculosis, Helicobacter pylori).
Journal ArticleDOI

CD14 + CD16 + monocytes are the main target of Zika virus infection in peripheral blood mononuclear cells in a paediatric study in Nicaragua.

Daniela Michlmayr, +5 more
- 02 Oct 2017 - 
TL;DR: A detailed picture of the innate immune profile of ZIKV infection is provided and highlights the important role of monocytes, and CD14+CD16+ monocytes in particular.
Journal ArticleDOI

HIV persists in CCR6+CD4+ T cells from colon and blood during antiretroviral therapy

Annie Gosselin, +12 more
- 02 Jan 2017 - 
TL;DR: CCR6 is a marker for colon and blood CD4+ T cells enriched for replication-competent HIV DNA and novel eradication strategies should target HIV persistence in CCR6+CD4- T cells from various anatomic sites.
References
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Journal ArticleDOI

Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators.

Frank J. Palella, +7 more
- 26 Mar 1998 - 
TL;DR: The recent declines in morbidity and mortality due to AIDS are attributable to the use of more intensive antiretroviral therapies.
Journal ArticleDOI

Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).

Françoise Barré-Sinoussi, +11 more
- 20 May 1983 - 
TL;DR: From these studies it is concluded that this virus as well as the previous HTLV isolates belong to a general family of T-lymphotropic retroviruses that are horizontally transmitted in humans and may be involved in several pathological syndromes, including AIDS.
Journal ArticleDOI

Prevention of HIV-1 Infection with Early Antiretroviral Therapy

Myron S. Cohen, +34 more
- 10 Aug 2011 - 
TL;DR: In this article, Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples.
Journal ArticleDOI

Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection

Stephanie Michaels, +2 more
- 06 Aug 1998 - 
TL;DR: A study was conducted to evaluate the impact of protease inhibitors on the rates of selected opportunistic processes and mortality in patients with AIDS and found similar results.
Journal ArticleDOI

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

David D. Ho, +5 more
- 12 Jan 1995 - 
TL;DR: Treatment of infected patients with ABT-538 causes plasma HIV-1 levels to decrease exponentially and CD4 lymphocyte counts to rise substantially, indicating that replication of HIV- 1 in vivo is continuous and highly productive, driving the rapid turnover ofCD4 lymphocytes.
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