Role of neuroinflammation in neurodegenerative diseases (Review)
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TLDR
The role played by the inflammatory process in neurodegenerative diseases is investigated, particularly in the elderly in whom inflammatory mechanisms are linked to the pathogenesis of functional and mental impairments.Abstract:
Neurodegeneration is a phenomenon that occurs in the central nervous system through the hallmarks associating the loss of neuronal structure and function. Neurodegeneration is observed after viral insult and mostly in various so-called 'neurodegenerative diseases', generally observed in the elderly, such as Alzheimer's disease, multiple sclerosis, Parkinson's disease and amyotrophic lateral sclerosis that negatively affect mental and physical functioning. Causative agents of neurodegeneration have yet to be identified. However, recent data have identified the inflammatory process as being closely linked with multiple neurodegenerative pathways, which are associated with depression, a consequence of neurodegenerative disease. Accordingly, pro‑inflammatory cytokines are important in the pathophysiology of depression and dementia. These data suggest that the role of neuroinflammation in neurodegeneration must be fully elucidated, since pro‑inflammatory agents, which are the causative effects of neuroinflammation, occur widely, particularly in the elderly in whom inflammatory mechanisms are linked to the pathogenesis of functional and mental impairments. In this review, we investigated the role played by the inflammatory process in neurodegenerative diseases.read more
Citations
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Journal ArticleDOI
Inflammation as a central mechanism in Alzheimer's disease
Jefferson W. Kinney,Shane M. Bemiller,Andrew S. Murtishaw,Amanda M. Leisgang,Arnold Salazar,Bruce T. Lamb +5 more
TL;DR: An overview of inflammation in AD is provided and a detailed coverage of a number of microglia‐related signaling mechanisms that have been implicated in AD are reviewed.
Neuroinflammation Induces Neurodegeneration.
Duraisamy Kempuraj,Ramasamy Thangavel,Prashant Natteru,Govindhasamy Pushpavathi Selvakumar,Daniyal Saeed,Haris Zahoor,Smita Zaheer,Shankar S. Iyer,Asgar Zaheer +8 more
TL;DR: Though inflammation is crucial in the onset and the progression of neurodegenerative diseases, anti-inflammatory drugs do not provide significant therapeutic effects in these patients till date, as the disease pathogenesis is not yet clearly understood.
Journal ArticleDOI
Inflammatory Response in the CNS: Friend or Foe?
TL;DR: Altered mutual regulation of p53 protein, a major tumor suppressor, and NF-κB, the major regulator of inflammation, seems to be crucial for the shift from beneficial to detrimental effects of neuroinflammatory reactions in neurodegeneration.
Journal ArticleDOI
Neuroinflammation pathways: a general review
Tara Shabab,Ramin Khanabdali,Soheil Zorofchian Moghadamtousi,Habsah Abdul Kadir,Gokula Mohan +4 more
TL;DR: Attenuating cytokines production and controlling microglial inflammatory response, which are the result of understanding neuroinflammation pathways, are considered therapeutic strategies for treating neurodegenerative diseases with an inflammatory component.
Journal ArticleDOI
Anti-inflammatory effects of flavonoids in neurodegenerative disorders
TL;DR: The present work reviews the role of inflammation in neurodegenerative diseases, highlighting the potential therapeutic effects of flavonoids as a promising approach to develop innovative neuroprotective strategy.
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