Open Access
Supplementary Materials for Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut
Sebastian E. Winter,Maria G. Winter,Mariana N. Xavier,A. Marijke Keestra,Richard Laughlin,Gabriel Gomez,Jing Wu,Ina Popova,Sanjai J. Parikh,L. Garry Adams,Renée M. Tsolis,Andreas J. Bäumler +11 more
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The article was published on 2013-01-01 and is currently open access. It has received 505 citations till now.read more
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In vivo synthesis of bacterial amyloid curli contributes to joint inflammation during S. Typhimurium infection.
Amanda L. Miller,J. Alex Pasternak,Nicole J. Medeiros,Lauren K. Nicastro,Sarah A. Tursi,Elizabeth G. Hansen,Elizabeth G. Hansen,Ryan Krochak,Ryan Krochak,Akosiererem S. Sokaribo,Akosiererem S. Sokaribo,Keith D. MacKenzie,Keith D. MacKenzie,Melissa B. Palmer,Melissa B. Palmer,Dakoda J. Herman,Dakoda J. Herman,Nikole L. Watson,Nikole L. Watson,Yi Zhang,Heather L. Wilson,R. Paul Wilson,Aaron White,Aaron White,Çagla Tükel +24 more
TL;DR: It is hypothesized that in vivo synthesis of curli contributes to known complications of enteric infections and suggested that cross-seeding interactions can occur between pathogen-produced amyloids and amyloidogenic proteins of the host.
Journal ArticleDOI
The electrifying energy of gut microbes
Laty A. Cahoon,Nancy E. Freitag +1 more
TL;DR: Human gut bacteria use a previously unknown electron-transfer pathway, which reveals an energy-generation system used by bacteria in the human gut.
Journal ArticleDOI
A prospective study in severely injured patients reveals an altered gut microbiome is associated with transfusion volume.
Susannah E. Nicholson,David M Burmeister,Taylor R Johnson,Yi Zou,Zhao Lai,Shannon Scroggins,Mark DeRosa,Rachelle B. Jonas,Daniel Merrill,Caroline S Zhu,Larry M. Newton,Ronald M. Stewart,Martin G. Schwacha,Donald H. Jenkins,Brian J. Eastridge +14 more
TL;DR: The gut microbiome of trauma patients may provide valuable diagnostic and therapeutic insight for the improvement of outcomes postinjury and may be aided by early massive transfusion.
Journal ArticleDOI
The SOS Response Mediates Sustained Colonization of the Mammalian Gut.
TL;DR: Understanding of the importance of a functional SOS response for bacterial fitness in the context of a complex physiological environment is extended and the SOS response is highlighted as a possible mechanism that contributes to ongoing genomic changes, including potential antibiotic resistance, in the microbiome of healthy hosts.
Journal ArticleDOI
Modulation of Gut Microbial Community and Metabolism by Dietary Glycyl-Glutamine Supplementation May Favor Weaning Transition in Piglets.
Yiqin Yan,Baoyang Xu,Boqi Yin,Xiaofan Xu,Yaorong Niu,Yimei Tang,Xinkai Wang,Chunlin Xie,Tao Yang,Shuyi Zhou,Xianghua Yan,Libao Ma +11 more
TL;DR: Dietary Gly-Gln supplementation beneficially altered the gut microbiota by increasing bacterial loading, elevating alpha diversity, and increasing the relative abundance of anaerobes and fiber-degrading bacteria (Phylum Fibrobacteres).
References
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One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
TL;DR: A simple and highly efficient method to disrupt chromosomal genes in Escherichia coli in which PCR primers provide the homology to the targeted gene(s), which should be widely useful, especially in genome analysis of E. coli and other bacteria.
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A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in Gram negative bacteria
TL;DR: In this paper, a new vector strategy for the insertion of foreign genes into the genomes of gram negative bacteria not closely related to Escherichia coli was developed, which can utilize any gram negative bacterium as a recipient for conjugative DNA transfer.
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Diversity of the human intestinal microbial flora.
Paul B. Eckburg,Elisabeth M. Bik,Charles N. Bernstein,Elizabeth Purdom,Les Dethlefsen,Michael Sargent,Steven R. Gill,Karen E. Nelson,David A. Relman,David A. Relman,David A. Relman +10 more
TL;DR: A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered.
Journal ArticleDOI
Obesity alters gut microbial ecology
Ruth E. Ley,Fredrik Bäckhed,Peter J. Turnbaugh,Catherine A. Lozupone,Robin D. Knight,Jeffrey I. Gordon +5 more
TL;DR: Analysis of the microbiota of genetically obese ob/ob mice, lean ob/+ and wild-type siblings, and their ob/+ mothers, all fed the same polysaccharide-rich diet, indicates that obesity affects the diversity of the gut microbiota and suggests that intentional manipulation of community structure may be useful for regulating energy balance in obese individuals.
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Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Daniel N. Frank,Allison L. St. Amand,Robert A. Feldman,Edgar C. Boedeker,Noam Harpaz,Norman R. Pace +5 more
TL;DR: Patient stratification by GI microbiota provides further evidence that CD represents a spectrum of disease states and suggests that treatment of some forms of IBD may be facilitated by redress of the detected microbiological imbalances.