Open Access
Supplementary Materials for Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut
Sebastian E. Winter,Maria G. Winter,Mariana N. Xavier,A. Marijke Keestra,Richard Laughlin,Gabriel Gomez,Jing Wu,Ina Popova,Sanjai J. Parikh,L. Garry Adams,Renée M. Tsolis,Andreas J. Bäumler +11 more
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The article was published on 2013-01-01 and is currently open access. It has received 505 citations till now.read more
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Role of the Microbiota in Immunity and Inflammation
Yasmine Belkaid,Timothy W. Hand +1 more
TL;DR: In high-income countries, overuse of antibiotics, changes in diet, and elimination of constitutive partners, such as nematodes, may have selected for a microbiota that lack the resilience and diversity required to establish balanced immune responses.
Journal ArticleDOI
Proteobacteria: Microbial signature of dysbiosis in gut microbiota
TL;DR: This work reviews studies that explored the association between an abnormal expansion of Proteobacteria and a compromised ability to maintain a balanced gut microbial community and proposes that an increased prevalence of ProTeobacteria is a potential diagnostic signature of dysbiosis and risk of disease.
Journal ArticleDOI
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota
Kristoffer Forslund,Falk Hildebrand,Falk Hildebrand,Trine Nielsen,Gwen Falony,Gwen Falony,Shinichi Sunagawa,Edi Prifti,Sara Vieira-Silva,Sara Vieira-Silva,Valborg Gudmundsdottir,Helle Krogh Pedersen,Manimozhiyan Arumugam,Karsten Kristiansen,Anita Y. Voigt,Anita Y. Voigt,Henrik Vestergaard,Rajna Hercog,Paul I. Costea,Jens Roat Kultima,Junhua Li,Torben Jørgensen,Torben Jørgensen,Florence Levenez,Joël Doré,H. Bjørn Nielsen,Søren Brunak,Søren Brunak,Jeroen Raes,Jeroen Raes,Jeroen Raes,Torben Hansen,Torben Hansen,Jun Wang,S. Dusko Ehrlich,S. Dusko Ehrlich,Peer Bork,Oluf Pedersen +37 more
TL;DR: A unified signature of gut microbiome shifts in T2D with a depletion of butyrate-producing taxa is reported, highlighting the need to disentangle gut microbiota signatures of specific human diseases from those of medication.
Journal ArticleDOI
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
Jose U. Scher,Andrew Sczesnak,Andrew Sczesnak,Randy S. Longman,Randy S. Longman,Nicola Segata,Nicola Segata,Carles Ubeda,Carles Ubeda,Craig M. Bielski,Tim Rostron,Vincenzo Cerundolo,Eric G. Pamer,Steven B. Abramson,Curtis Huttenhower,Dan R. Littman +15 more
TL;DR: The presence of Prevotella copri is identified as strongly correlated with disease in new-onset untreated rheumatoid arthritis (NORA) patients and uniquePrevotella genes that correlate with disease are identified.
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Control of pathogens and pathobionts by the gut microbiota.
TL;DR: The mechanisms that regulate the ability of the microbiota to restrain pathogen growth are complex and include competitive metabolic interactions, localization to intestinal niches and induction of host immune responses.
References
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Journal ArticleDOI
Analysis of the Genome Structure of the Nonpathogenic Probiotic Escherichia coli Strain Nissle 1917
Lubomir Grozdanov,Carsten Raasch,Jürgen Schulze,Ulrich Sonnenborn,Gerhard Gottschalk,Jörg Hacker,Ulrich Dobrindt +6 more
TL;DR: This strain's genome structure has been analyzed by sequence context screening of tRNA genes as a potential indication of chromosomal integration of horizontally acquired DNA, sequence analysis of 280 kb of genomic islands (GEIs) coding for important fitness factors, and comparison of Nissle 1917 genome content with that of other E. coli strains by DNA-DNA hybridization.
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Methionine oxidation by reactive oxygen species: reaction mechanisms and relevance to Alzheimer's disease
TL;DR: Detailed mechanistic schemes for the reactions of various prominent, biologically relevant ROS with methionine and organic model sulfides are provided, characterizing the physico-chemical parameters, which control this mechanism, and its physiological relevance, specifically for the oxidation and neurotoxicity of the Alzheimer's disease beta-amyloid peptide (betaAP).
Journal ArticleDOI
T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation.
Axel Roers,Lisa Siewe,Elke Strittmatter,Martina Deckert,Dirk Schlüter,Dirk Schlüter,Werner Stenzel,Achim D. Gruber,Thomas Krieg,Klaus Rajewsky,Werner Müller +10 more
TL;DR: The role of T cell–derived IL-10 in the regulation of Tcell responses is addressed and it is demonstrated that endotoxic shock and the irritant response of the skin are controlled byIL-10 from other cell types.
Journal ArticleDOI
Greatly increased luminal nitric oxide in ulcerative colitis
TL;DR: A role for nitric oxide in ulcerative colitis has been suggested and luminal NO is rapidly and easily measurable and may be used to monitor inflammatory bowel disease.
Journal ArticleDOI
Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4.
Markus M. Heimesaat,André Fischer,Britta Siegmund,Andreas Kupz,Julia Niebergall,David Fuchs,Hannah-Katharina Jahn,Marina A. Freudenberg,Christoph Loddenkemper,Arvind Batra,Hans-Anton Lehr,Oliver Liesenfeld,Michael Blaut,Ulf B. Göbel,Ralf R. Schumann,Stefan Bereswill +15 more
TL;DR: DSS-induced colitis is characterized by a shift in the intestinal microflora towards pro-inflammatory Gram-negative bacteria and may serve as a biomarker for colitis severity and DSS- induced barrier damage seems to be a valuable model to further identify bacterial factors involved in maintaining intestinal homeostasis and to test therapeutic interventions based upon anti-TLR strategies.