Open Access
Supplementary Materials for Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut
Sebastian E. Winter,Maria G. Winter,Mariana N. Xavier,A. Marijke Keestra,Richard Laughlin,Gabriel Gomez,Jing Wu,Ina Popova,Sanjai J. Parikh,L. Garry Adams,Renée M. Tsolis,Andreas J. Bäumler +11 more
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The article was published on 2013-01-01 and is currently open access. It has received 505 citations till now.read more
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Role of the Microbiota in Immunity and Inflammation
Yasmine Belkaid,Timothy W. Hand +1 more
TL;DR: In high-income countries, overuse of antibiotics, changes in diet, and elimination of constitutive partners, such as nematodes, may have selected for a microbiota that lack the resilience and diversity required to establish balanced immune responses.
Journal ArticleDOI
Proteobacteria: Microbial signature of dysbiosis in gut microbiota
TL;DR: This work reviews studies that explored the association between an abnormal expansion of Proteobacteria and a compromised ability to maintain a balanced gut microbial community and proposes that an increased prevalence of ProTeobacteria is a potential diagnostic signature of dysbiosis and risk of disease.
Journal ArticleDOI
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota
Kristoffer Forslund,Falk Hildebrand,Falk Hildebrand,Trine Nielsen,Gwen Falony,Gwen Falony,Shinichi Sunagawa,Edi Prifti,Sara Vieira-Silva,Sara Vieira-Silva,Valborg Gudmundsdottir,Helle Krogh Pedersen,Manimozhiyan Arumugam,Karsten Kristiansen,Anita Y. Voigt,Anita Y. Voigt,Henrik Vestergaard,Rajna Hercog,Paul I. Costea,Jens Roat Kultima,Junhua Li,Torben Jørgensen,Torben Jørgensen,Florence Levenez,Joël Doré,H. Bjørn Nielsen,Søren Brunak,Søren Brunak,Jeroen Raes,Jeroen Raes,Jeroen Raes,Torben Hansen,Torben Hansen,Jun Wang,S. Dusko Ehrlich,S. Dusko Ehrlich,Peer Bork,Oluf Pedersen +37 more
TL;DR: A unified signature of gut microbiome shifts in T2D with a depletion of butyrate-producing taxa is reported, highlighting the need to disentangle gut microbiota signatures of specific human diseases from those of medication.
Journal ArticleDOI
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
Jose U. Scher,Andrew Sczesnak,Andrew Sczesnak,Randy S. Longman,Randy S. Longman,Nicola Segata,Nicola Segata,Carles Ubeda,Carles Ubeda,Craig M. Bielski,Tim Rostron,Vincenzo Cerundolo,Eric G. Pamer,Steven B. Abramson,Curtis Huttenhower,Dan R. Littman +15 more
TL;DR: The presence of Prevotella copri is identified as strongly correlated with disease in new-onset untreated rheumatoid arthritis (NORA) patients and uniquePrevotella genes that correlate with disease are identified.
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Control of pathogens and pathobionts by the gut microbiota.
TL;DR: The mechanisms that regulate the ability of the microbiota to restrain pathogen growth are complex and include competitive metabolic interactions, localization to intestinal niches and induction of host immune responses.
References
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Journal ArticleDOI
Gut inflammation provides a respiratory electron acceptor for Salmonella
Sebastian E. Winter,Parameth Thiennimitr,Parameth Thiennimitr,Maria G. Winter,Brian P. Butler,Douglas L. Huseby,Robert W. Crawford,Joseph M. Russell,Charles L. Bevins,L. Garry Adams,Renée M. Tsolis,John R. Roth,Andreas J. Bäumler +12 more
TL;DR: It is shown that reactive oxygen species generated during inflammation react with endogenous, luminal sulphur compounds (thiosulphate) to form a new respiratory electron acceptor, tetrathionate, that allows the pathogen to use respiration to compete with fermenting gut microbes.
Journal ArticleDOI
Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota
Bärbel Stecher,Riccardo Robbiani,Alan W. Walker,Astrid M. Westendorf,Manja Barthel,Marcus Kremer,Samuel Chaffron,Andrew J. Macpherson,Jan Buer,Julian Parkhill,Gordon Dougan,Christian von Mering,Wolf-Dietrich Hardt +12 more
TL;DR: Manipulation of the intestinal microbiota by the enteropathogenic bacterium Salmonella enterica subspecies 1 serovar Typhimurium in a mouse colitis model reveals a new concept in infectious disease: in contrast to current thinking, inflammation is not always detrimental for the pathogen.
Journal ArticleDOI
Spectrophotometric Determination of Nitrate with a Single Reagent
TL;DR: In this paper, a spectrophotometric procedure for determination of nitrate in water, soil extracts, and a variety of other sample types is described using one reagent solution which is easily prepared and stored.
Journal ArticleDOI
Alterations of the dominant faecal bacterial groups in patients with Crohn's disease of the colon
Philippe Seksik,Lionel Rigottier-Gois,Geneviève Gramet,Malène Sutren,P Pochart,P Marteau,R. Jian,Joël Doré +7 more
TL;DR: Enterobacteria were observed significantly more frequently in CD than in health, and more than 30% of the dominant flora belonged to yet undefined phylogenetic groups, suggesting the biodiversity of the microflora remains high in patients with CD.
Journal ArticleDOI
Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis
Wendy S. Garrett,Carey Ann Gallini,Tanya Yatsunenko,Monia Michaud,Andrea M. DuBois,Mary L. Delaney,Shivesh Punit,Maria Karlsson,Lynn Bry,Jonathan N. Glickman,Jeffrey I. Gordon,Andrew B. Onderdonk,Laurie H. Glimcher,Laurie H. Glimcher +13 more
TL;DR: The presence of Klebsiella pneumoniae and Proteus mirabilis correlates with colitis in TRUC animals, and these TRUC-derived strains can elicit colitis but require a maternally transmitted endogenous microbial community for maximal intestinal inflammation.