Open Access
Supplementary Materials for Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut
Sebastian E. Winter,Maria G. Winter,Mariana N. Xavier,A. Marijke Keestra,Richard Laughlin,Gabriel Gomez,Jing Wu,Ina Popova,Sanjai J. Parikh,L. Garry Adams,Renée M. Tsolis,Andreas J. Bäumler +11 more
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The article was published on 2013-01-01 and is currently open access. It has received 505 citations till now.read more
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Learning from bacterial competition in the host to develop antimicrobials
TL;DR: What can be learned from investigating microbial competition in vivo and how this knowledge can be utilized to devise new narrow-spectrum therapeutics that target bacterial pathogens while minimizing deleterious effects to the microbiota are discussed.
Journal ArticleDOI
Human Intestinal Microbiota: Interaction Between Parasites and the Host Immune Response.
Oswaldo Partida-Rodriguez,Angélica Serrano-Vázquez,Miriam Nieves-Ramírez,Patricia Morán,Liliana Rojas,Tobias Portillo,Enrique González,Eric Hernández,B. Brett Finlay,Cecilia Ximénez +9 more
TL;DR: Recent findings about the immunoregulatory effect of intestinal microbiota with regards to intestinal colonization by protozoa are discussed, focusing on infections by Entamoeba histolytica, Blastocystis spp, Giardia duodenalis, Toxoplasma gondii and Cryptosporidium parvum.
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A Review of Traumatic Brain Injury and the Gut Microbiome: Insights into Novel Mechanisms of Secondary Brain Injury and Promising Targets for Neuroprotection
Caroline S Zhu,Ramesh Grandhi,Ramesh Grandhi,Ramesh Grandhi,Thomas Tyler Patterson,Susannah E. Nicholson +5 more
TL;DR: Examining traumatic brain injury (TBI) in relation to this axis is examined and potential interventions, which may serve as targets for improving clinical outcomes and preventing secondary brain injury are explored.
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Precision antimicrobial therapeutics: the path of least resistance?
Caitlin N. Spaulding,Caitlin N. Spaulding,Roger D. Klein,Henry L. Schreiber,James W. Janetka,Scott J. Hultgren +5 more
TL;DR: The benefits, progress, and roadblocks to the development of precision antimicrobial therapeutic approaches hold great promise in a variety of disease systems, including UTI, CD, otitis media (OM), and others.
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Fecal microbiota transplantation in inflammatory bowel disease: the quest for the holy grail
TL;DR: The results of the first studies suggest that FMT could be a promising therapy in IBD, but more studies are needed to define the best indications, optimal timing, frequency, mode of delivery, and the optimal donor for each patient.
References
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One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
TL;DR: A simple and highly efficient method to disrupt chromosomal genes in Escherichia coli in which PCR primers provide the homology to the targeted gene(s), which should be widely useful, especially in genome analysis of E. coli and other bacteria.
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A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in Gram negative bacteria
TL;DR: In this paper, a new vector strategy for the insertion of foreign genes into the genomes of gram negative bacteria not closely related to Escherichia coli was developed, which can utilize any gram negative bacterium as a recipient for conjugative DNA transfer.
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Diversity of the human intestinal microbial flora.
Paul B. Eckburg,Elisabeth M. Bik,Charles N. Bernstein,Elizabeth Purdom,Les Dethlefsen,Michael Sargent,Steven R. Gill,Karen E. Nelson,David A. Relman,David A. Relman,David A. Relman +10 more
TL;DR: A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered.
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Obesity alters gut microbial ecology
Ruth E. Ley,Fredrik Bäckhed,Peter J. Turnbaugh,Catherine A. Lozupone,Robin D. Knight,Jeffrey I. Gordon +5 more
TL;DR: Analysis of the microbiota of genetically obese ob/ob mice, lean ob/+ and wild-type siblings, and their ob/+ mothers, all fed the same polysaccharide-rich diet, indicates that obesity affects the diversity of the gut microbiota and suggests that intentional manipulation of community structure may be useful for regulating energy balance in obese individuals.
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Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Daniel N. Frank,Allison L. St. Amand,Robert A. Feldman,Edgar C. Boedeker,Noam Harpaz,Norman R. Pace +5 more
TL;DR: Patient stratification by GI microbiota provides further evidence that CD represents a spectrum of disease states and suggests that treatment of some forms of IBD may be facilitated by redress of the detected microbiological imbalances.