Open Access
Supplementary Materials for Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut
Sebastian E. Winter,Maria G. Winter,Mariana N. Xavier,A. Marijke Keestra,Richard Laughlin,Gabriel Gomez,Jing Wu,Ina Popova,Sanjai J. Parikh,L. Garry Adams,Renée M. Tsolis,Andreas J. Bäumler +11 more
About:
The article was published on 2013-01-01 and is currently open access. It has received 505 citations till now.read more
Citations
More filters
Journal ArticleDOI
How the Structure of the Large Subunit Controls Function in an Oxygen-Tolerant [Nife]-Hydrogenase.
TL;DR: The H229A variant was found to have lost the overpotential requirement for activity that is always observed with oxygen-tolerant [NiFe]-hydrogenases and it is possible that His229 has a role in stabilizing the super-oxidized form of the proximal cluster in the presence of oxygen.
Journal ArticleDOI
Anaerobic choline metabolism in microcompartments promotes growth and swarming of Proteus mirabilis
Eleanor Jameson,Tiantian Fu,Ian R. Brown,Konrad Paszkiewicz,Kevin J. Purdy,Stefanie Frank,Yin Chen +6 more
TL;DR: It is demonstrated that choline is an important growth substrate for representatives of G ammaproteobacteria and is revealed as an adaptation strategy for P .
Journal ArticleDOI
The Dynamic Interactions between Salmonella and the Microbiota, within the Challenging Niche of the Gastrointestinal Tract
TL;DR: Salmonella have developed remarkable strategies to initially shield against host defenses and to transiently compete against the intestinal microbiota leading to successful infections, however, the immunocompetent host is subsequently able to reestablish control and clear the infection.
Journal ArticleDOI
The Enteric Two‐Step: nutritional strategies of bacterial pathogens within the gut
TL;DR: Recent findings are synthesized to support a five‐stage model describing the transition between a healthy microbiota and one dominated by a pathogen and disease, and how this emerging paradigm of pathogen life within the lumen of the gut is giving rise to novel therapeutic strategies.
Journal ArticleDOI
Complex Bacterial Consortia Reprogram the Colitogenic Activity of Enterococcus faecalis in a Gnotobiotic Mouse Model of Chronic, Immune-Mediated Colitis
Isabella Lengfelder,Irina Sava,Jonathan J. Hansen,Karin Kleigrewe,Jeremy Herzog,Klaus Neuhaus,Thomas Hofmann,R. Balfour Sartor,Dirk Haller +8 more
TL;DR: It is demonstrated that complex bacterial consortia interactions reprogram the gene expression profile and colitogenic activity of the opportunistic pathogen E. faecalis toward a protective function in complex bacterial communities.
References
More filters
Journal ArticleDOI
One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
TL;DR: A simple and highly efficient method to disrupt chromosomal genes in Escherichia coli in which PCR primers provide the homology to the targeted gene(s), which should be widely useful, especially in genome analysis of E. coli and other bacteria.
Journal ArticleDOI
A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in Gram negative bacteria
TL;DR: In this paper, a new vector strategy for the insertion of foreign genes into the genomes of gram negative bacteria not closely related to Escherichia coli was developed, which can utilize any gram negative bacterium as a recipient for conjugative DNA transfer.
Journal ArticleDOI
Diversity of the human intestinal microbial flora.
Paul B. Eckburg,Elisabeth M. Bik,Charles N. Bernstein,Elizabeth Purdom,Les Dethlefsen,Michael Sargent,Steven R. Gill,Karen E. Nelson,David A. Relman,David A. Relman,David A. Relman +10 more
TL;DR: A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered.
Journal ArticleDOI
Obesity alters gut microbial ecology
Ruth E. Ley,Fredrik Bäckhed,Peter J. Turnbaugh,Catherine A. Lozupone,Robin D. Knight,Jeffrey I. Gordon +5 more
TL;DR: Analysis of the microbiota of genetically obese ob/ob mice, lean ob/+ and wild-type siblings, and their ob/+ mothers, all fed the same polysaccharide-rich diet, indicates that obesity affects the diversity of the gut microbiota and suggests that intentional manipulation of community structure may be useful for regulating energy balance in obese individuals.
Journal ArticleDOI
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Daniel N. Frank,Allison L. St. Amand,Robert A. Feldman,Edgar C. Boedeker,Noam Harpaz,Norman R. Pace +5 more
TL;DR: Patient stratification by GI microbiota provides further evidence that CD represents a spectrum of disease states and suggests that treatment of some forms of IBD may be facilitated by redress of the detected microbiological imbalances.