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Supplementary Materials for Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut
Sebastian E. Winter,Maria G. Winter,Mariana N. Xavier,A. Marijke Keestra,Richard Laughlin,Gabriel Gomez,Jing Wu,Ina Popova,Sanjai J. Parikh,L. Garry Adams,Renée M. Tsolis,Andreas J. Bäumler +11 more
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The article was published on 2013-01-01 and is currently open access. It has received 505 citations till now.read more
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Colonization Resistance: Battle of the Bugs or Ménage à Trois with the Host?
Alanna M. Spees,Christopher A. Lopez,Dawn D. Kingsbury,Sebastian E. Winter,Andreas J. Bäumler +4 more
TL;DR: Conventional wisdom holds that resident Bacteroidia and Clostridia confer colonization resistance by “competitive exclusion” of Enterobacteriaceae (phylum Proteobacteria) through microbe-microbe interactions, but recent studies draw a tantalizing new picture, which suggests that host interactions might play a central role in shaping the microbial community structure.
Journal ArticleDOI
Escherichia coli limits Salmonella Typhimurium infections after diet shifts and fat-mediated microbiota perturbation in mice.
Sandra Y. Wotzka,Markus Kreuzer,Lisa A. Maier,Markus Arnoldini,Bidong D. Nguyen,Alexander O. Brachmann,Dorothée L. Berthold,Mirjam Zünd,Annika Hausmann,Erik Bakkeren,Daniel Hoces,Ersin Gül,Markus Beutler,Tamas Dolowschiak,Michael B. Zimmermann,Tobias Fuhrer,Kathrin Moor,Uwe Sauer,Athanasios Typas,Jörn Piel,Médéric Diard,Andrew J. Macpherson,Bärbel Stecher,Shinichi Sunagawa,Emma Slack,Wolf-Dietrich Hardt +25 more
TL;DR: The mouse model may be useful for studying pathogen–microbiota–host interactions, the protective effect of E. coli, to analyse the spread of resistance plasmids and assess the impact of food components on the infection process.
Journal ArticleDOI
The impact of intestinal inflammation on the nutritional environment of the gut microbiota
TL;DR: The changes in microbial nutrient utilization that accompany intestinal inflammation and the consequent changes in the composition of gut-associated microbial communities are reviewed.
Journal ArticleDOI
Gut microbial dysbiosis is associated with development and progression of radiation enteritis during pelvic radiotherapy
Zhongqiu Wang,Qingxin Wang,Qingxin Wang,Xia Wang,Li Zhu,Jie Chen,Bailin Zhang,Ye Chen,Zhiyong Yuan +8 more
TL;DR: The results suggest that dysbiosis of gut microbiota may contribute to development and progression of RE, and Gut microbiota can offer a set of biomarkers for prediction, disease activity evaluation and treatment selection in RE.
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Microbiota-Inducible Innate Immune Siderophore Binding Protein Lipocalin 2 Is Critical for Intestinal Homeostasis
Vishal Singh,Beng San Yeoh,Benoit Chassaing,Benyue Zhang,Piu Saha,Xia Xiao,Deepika Awasthi,Rangaiah Shashidharamurthy,Madhu Dikshit,Andrew T. Gewirtz,Matam Vijay-Kumar +10 more
TL;DR: Lcn2 is a bacterially induced, MyD88-dependent protein that plays an important role in gut homeostasis and a pivotal role on challenge and therapeutic manipulation of Lcn2 levels may provide a strategy to help manage diseases driven by alteration of the gut microbiota.
References
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One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
TL;DR: A simple and highly efficient method to disrupt chromosomal genes in Escherichia coli in which PCR primers provide the homology to the targeted gene(s), which should be widely useful, especially in genome analysis of E. coli and other bacteria.
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A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in Gram negative bacteria
TL;DR: In this paper, a new vector strategy for the insertion of foreign genes into the genomes of gram negative bacteria not closely related to Escherichia coli was developed, which can utilize any gram negative bacterium as a recipient for conjugative DNA transfer.
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Diversity of the human intestinal microbial flora.
Paul B. Eckburg,Elisabeth M. Bik,Charles N. Bernstein,Elizabeth Purdom,Les Dethlefsen,Michael Sargent,Steven R. Gill,Karen E. Nelson,David A. Relman,David A. Relman,David A. Relman +10 more
TL;DR: A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered.
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Obesity alters gut microbial ecology
Ruth E. Ley,Fredrik Bäckhed,Peter J. Turnbaugh,Catherine A. Lozupone,Robin D. Knight,Jeffrey I. Gordon +5 more
TL;DR: Analysis of the microbiota of genetically obese ob/ob mice, lean ob/+ and wild-type siblings, and their ob/+ mothers, all fed the same polysaccharide-rich diet, indicates that obesity affects the diversity of the gut microbiota and suggests that intentional manipulation of community structure may be useful for regulating energy balance in obese individuals.
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Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Daniel N. Frank,Allison L. St. Amand,Robert A. Feldman,Edgar C. Boedeker,Noam Harpaz,Norman R. Pace +5 more
TL;DR: Patient stratification by GI microbiota provides further evidence that CD represents a spectrum of disease states and suggests that treatment of some forms of IBD may be facilitated by redress of the detected microbiological imbalances.