Open Access
Supplementary Materials for Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut
Sebastian E. Winter,Maria G. Winter,Mariana N. Xavier,A. Marijke Keestra,Richard Laughlin,Gabriel Gomez,Jing Wu,Ina Popova,Sanjai J. Parikh,L. Garry Adams,Renée M. Tsolis,Andreas J. Bäumler +11 more
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The article was published on 2013-01-01 and is currently open access. It has received 505 citations till now.read more
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Inflammation Fuels Colicin Ib-Dependent Competition of Salmonella Serovar Typhimurium and E. coli in Enterobacterial Blooms
Lubov Petkova Nedialkova,Rémy Denzler,Martin B. Koeppel,Manuel Diehl,Diana Ring,Thorsten Wille,Roman G. Gerlach,Bärbel Stecher +7 more
TL;DR: A so-far unappreciated role of inflammation-inflicted blooms as an environment favouring ColIb-dependent competition of pathogenic and commensal representatives of the Enterobacteriaceae family is uncovers.
Journal ArticleDOI
The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense
Shuiqing Hu,Lan Peng,Youn-Tae Kwak,Erin McElvania TeKippe,Erin McElvania TeKippe,Chandrashekhar Pasare,James S. Malter,Lora V. Hooper,Md. Hasan Zaki +8 more
TL;DR: It is shown that Aim2(-/-) mice are highly susceptible to dextran sodium sulfate-induced colitis that is associated with microbial dysbiosis as represented by higher colonic burden of commensal Escherichia coli and DNA sensing by AIM2 as a regulatory mechanism for maintaining intestinal homeostasis is implicate.
Journal ArticleDOI
Chemical and pathogen-induced inflammation disrupt the murine intestinal microbiome.
Mikayla A. Borton,Anice Sabag-Daigle,Jikang Wu,Lindsey M. Solden,Bridget S. O’Banion,Rebecca A. Daly,Richard A. Wolfe,Juan F. González,Vicki H. Wysocki,Brian M. M. Ahmer,Kelly C. Wrighton +10 more
TL;DR: The results show that enteropathogenic infection and intestinal inflammation are interrelated factors modulating gut homeostasis and may prove informative with regard to prophylactic or therapeutic strategies to prevent disruption of microbial communities, or promote their restoration.
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Nutritional Intervention for the Intestinal Development and Health of Weaned Pigs.
TL;DR: This review summarizes the current understanding of nutritional intervention on intestinal health and development of weaned pigs and the importance of mechanistic studies focusing on this research area.
Journal ArticleDOI
Bile duct injury and morbidity following cholecystectomy: a need for improvement
TL;DR: BDI rate requiring operative intervention have plateaued and remains at 0.23% despite increased experience with laparoscopy, and a clear opportunity is identified to improve the quality and safety of this operation.
References
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One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
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A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in Gram negative bacteria
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Paul B. Eckburg,Elisabeth M. Bik,Charles N. Bernstein,Elizabeth Purdom,Les Dethlefsen,Michael Sargent,Steven R. Gill,Karen E. Nelson,David A. Relman,David A. Relman,David A. Relman +10 more
TL;DR: A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered.
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Obesity alters gut microbial ecology
Ruth E. Ley,Fredrik Bäckhed,Peter J. Turnbaugh,Catherine A. Lozupone,Robin D. Knight,Jeffrey I. Gordon +5 more
TL;DR: Analysis of the microbiota of genetically obese ob/ob mice, lean ob/+ and wild-type siblings, and their ob/+ mothers, all fed the same polysaccharide-rich diet, indicates that obesity affects the diversity of the gut microbiota and suggests that intentional manipulation of community structure may be useful for regulating energy balance in obese individuals.
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Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Daniel N. Frank,Allison L. St. Amand,Robert A. Feldman,Edgar C. Boedeker,Noam Harpaz,Norman R. Pace +5 more
TL;DR: Patient stratification by GI microbiota provides further evidence that CD represents a spectrum of disease states and suggests that treatment of some forms of IBD may be facilitated by redress of the detected microbiological imbalances.