Open Access
Supplementary Materials for Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut
Sebastian E. Winter,Maria G. Winter,Mariana N. Xavier,A. Marijke Keestra,Richard Laughlin,Gabriel Gomez,Jing Wu,Ina Popova,Sanjai J. Parikh,L. Garry Adams,Renée M. Tsolis,Andreas J. Bäumler +11 more
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The article was published on 2013-01-01 and is currently open access. It has received 505 citations till now.read more
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Role of the Microbiota in Immunity and Inflammation
Yasmine Belkaid,Timothy W. Hand +1 more
TL;DR: In high-income countries, overuse of antibiotics, changes in diet, and elimination of constitutive partners, such as nematodes, may have selected for a microbiota that lack the resilience and diversity required to establish balanced immune responses.
Journal ArticleDOI
Proteobacteria: Microbial signature of dysbiosis in gut microbiota
TL;DR: This work reviews studies that explored the association between an abnormal expansion of Proteobacteria and a compromised ability to maintain a balanced gut microbial community and proposes that an increased prevalence of ProTeobacteria is a potential diagnostic signature of dysbiosis and risk of disease.
Journal ArticleDOI
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota
Kristoffer Forslund,Falk Hildebrand,Falk Hildebrand,Trine Nielsen,Gwen Falony,Gwen Falony,Shinichi Sunagawa,Edi Prifti,Sara Vieira-Silva,Sara Vieira-Silva,Valborg Gudmundsdottir,Helle Krogh Pedersen,Manimozhiyan Arumugam,Karsten Kristiansen,Anita Y. Voigt,Anita Y. Voigt,Henrik Vestergaard,Rajna Hercog,Paul I. Costea,Jens Roat Kultima,Junhua Li,Torben Jørgensen,Torben Jørgensen,Florence Levenez,Joël Doré,H. Bjørn Nielsen,Søren Brunak,Søren Brunak,Jeroen Raes,Jeroen Raes,Jeroen Raes,Torben Hansen,Torben Hansen,Jun Wang,S. Dusko Ehrlich,S. Dusko Ehrlich,Peer Bork,Oluf Pedersen +37 more
TL;DR: A unified signature of gut microbiome shifts in T2D with a depletion of butyrate-producing taxa is reported, highlighting the need to disentangle gut microbiota signatures of specific human diseases from those of medication.
Journal ArticleDOI
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
Jose U. Scher,Andrew Sczesnak,Andrew Sczesnak,Randy S. Longman,Randy S. Longman,Nicola Segata,Nicola Segata,Carles Ubeda,Carles Ubeda,Craig M. Bielski,Tim Rostron,Vincenzo Cerundolo,Eric G. Pamer,Steven B. Abramson,Curtis Huttenhower,Dan R. Littman +15 more
TL;DR: The presence of Prevotella copri is identified as strongly correlated with disease in new-onset untreated rheumatoid arthritis (NORA) patients and uniquePrevotella genes that correlate with disease are identified.
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Control of pathogens and pathobionts by the gut microbiota.
TL;DR: The mechanisms that regulate the ability of the microbiota to restrain pathogen growth are complex and include competitive metabolic interactions, localization to intestinal niches and induction of host immune responses.
References
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Ferrioxamine-mediated Iron(III) utilization by Salmonella enterica.
Robert A. Kingsley,Rolf Reissbrodt,Wolfgang Rabsch,Julian M. Ketley,Renée M. Tsolis,Paul Everest,Gordon Dougan,Andreas J. Bäumler,Mark Roberts,Peter H. Williams +9 more
TL;DR: The determinants involved in utilization of ferrioxamines B, E, and G by S. enterica serotype Typhimurium by performing siderophore cross-feeding bioassays were characterized and a foxA mutant was markedly attenuated in mice inoculated by either the intragastric or intravenous route.
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Contribution of flagellin pattern recognition to intestinal inflammation during Salmonella enterica serotype typhimurium infection.
Sebastian E. Winter,Sebastian E. Winter,Parameth Thiennimitr,Sean Paul Nuccio,Takeshi Haneda,Maria G. Winter,R. Paul Wilson,Joseph M. Russell,Thomas Henry,Quynh T. Tran,Sara D. Lawhon,Gabriel Gomez,Charles L. Bevins,Holger Rüssmann,Denise M. Monack,L. Garry Adams,Andreas J. Bäumler +16 more
TL;DR: It is suggested that pattern recognition of flagellin contributes to early innate host responses in the bovine ileal mucosa but not in the murine cecale mucosa, as well as in the streptomycin-pretreated wild-type mice.
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Salmonella-Induced Cell Death Is Not Required for Enteritis in Calves
Renato L. Santos,Renée M. Tsolis,Shuping Zhang,Thomas A. Ficht,Andreas J. Bäumler,L. G. Adams +5 more
TL;DR: It is indicated that serovar Typhimurium-induced cell death is not required to trigger an early inflammatory response and fluid accumulation in the ileum, and that proinflammatory cytokine interleukin-1β through cleavage is required for induction of fluid secretion and inflammation.
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The mechanism of carbon dioxide catalysis in the hydrogen peroxide N-oxidation of amines.
TL;DR: The BAP (NH4HCO3-activated peroxide) or CO2/H2O2 oxidation reagents are simple and economical methods for the preparation of tertiary amine N-oxides.
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Multipartite Regulation of rctB, the Replication Initiator Gene of Vibrio cholerae Chromosome II
TL;DR: RctB, the replication initiator for the smaller of the two chromosomes of Vibrio cholerae, can be rate limiting for chromosome II replication, and multiple modes of control on RctB are expected to reduce fluctuations in the initiator concentration and thereby help maintain chromosome copy number homeostasis.