Open Access
Supplementary Materials for Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut
Sebastian E. Winter,Maria G. Winter,Mariana N. Xavier,A. Marijke Keestra,Richard Laughlin,Gabriel Gomez,Jing Wu,Ina Popova,Sanjai J. Parikh,L. Garry Adams,Renée M. Tsolis,Andreas J. Bäumler +11 more
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The article was published on 2013-01-01 and is currently open access. It has received 505 citations till now.read more
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A Commensal Bacterium Promotes Virulence of an Opportunistic Pathogen via Cross-Respiration
TL;DR: The genetic requirements for the pathogenic bacterium Aggregatibacter actinomycetemcomitans to cause disease when coinfecting with the commensal bacterium Streptococcus gordonii were determined using global mutant fitness profiling.
Journal ArticleDOI
Reduce, Induce, Thrive: Bacterial Redox Sensing during Pathogenesis.
TL;DR: The abundance of oxidants and reductants must be balanced for an organism to thrive and bacteria have evolved methods to mitigate their deleterious consequences through the expression of detoxification enzymes, antioxidants, and systems to repair or degrade damaged proteins and DNA.
Journal ArticleDOI
Paneth Cell Defects Induce Microbiota Dysbiosis in Mice and Promote Visceral Hypersensitivity
Ambre Riba,Maïwenn Olier,Sonia Lacroix-Lamandé,Corinne Lencina,Valerie Bacquie,Cherryl Harkat,Marion Gillet,Marine Baron,Caroline Sommer,Virginie Mallet,Christel Salvador-Cartier,Fabrice Laurent,Vassilia Theodorou,Sandrine Ménard +13 more
TL;DR: Evidence is provided that Paneth cell function and intestinal dysbiosis are involved in visceral sensitivity, as reported from rats and mice separated from their mothers as newborns.
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Dysbiosis in the Gut Microbiota of Soil Fauna Explains the Toxicity of Tire Tread Particles
Jing Ding,Dong Zhu,Hong-Tao Wang,Simon Bo Lassen,Simon Bo Lassen,Qing-Lin Chen,Gang Li,Min Lv,Yong-Guan Zhu +8 more
TL;DR: It is demonstrated that TPs had an adverse effect on the survival and reproduction of the soil worms and disturbed the microbiota of the worm guts and surrounding soil, and showed that TP exposure caused an enrichment of microbial genera associated with opportunistic pathogenesis in theworm guts.
Journal ArticleDOI
Mutual interplay between IL-17-producing γδT cells and microbiota orchestrates oral mucosal homeostasis.
Anneke Wilharm,Yaara Tabib,Maria Nassar,Annika Reinhardt,Gabriel Mizraji,Inga Sandrock,Oded Heyman,Joana Barros-Martins,Yuval Aizenbud,Abed Khalaileh,Luba Eli-Berchoer,Eran Elinav,Asaf Wilensky,Reinhold Förster,Herve Bercovier,Immo Prinz,Avi-Hai Hovav +16 more
TL;DR: It is demonstrated that even though the gingiva develops after birth, the majority of gingival γδT cells are fetal thymus-derived Vγ6+ cells, and to a lesser extent Vγ1+ and Vγ4- cells, which suggest that oral mucosal homeostasis is shaped by reciprocal interplays between γ ΔT cells and local microbiota.
References
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One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
TL;DR: A simple and highly efficient method to disrupt chromosomal genes in Escherichia coli in which PCR primers provide the homology to the targeted gene(s), which should be widely useful, especially in genome analysis of E. coli and other bacteria.
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A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in Gram negative bacteria
TL;DR: In this paper, a new vector strategy for the insertion of foreign genes into the genomes of gram negative bacteria not closely related to Escherichia coli was developed, which can utilize any gram negative bacterium as a recipient for conjugative DNA transfer.
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Diversity of the human intestinal microbial flora.
Paul B. Eckburg,Elisabeth M. Bik,Charles N. Bernstein,Elizabeth Purdom,Les Dethlefsen,Michael Sargent,Steven R. Gill,Karen E. Nelson,David A. Relman,David A. Relman,David A. Relman +10 more
TL;DR: A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered.
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Obesity alters gut microbial ecology
Ruth E. Ley,Fredrik Bäckhed,Peter J. Turnbaugh,Catherine A. Lozupone,Robin D. Knight,Jeffrey I. Gordon +5 more
TL;DR: Analysis of the microbiota of genetically obese ob/ob mice, lean ob/+ and wild-type siblings, and their ob/+ mothers, all fed the same polysaccharide-rich diet, indicates that obesity affects the diversity of the gut microbiota and suggests that intentional manipulation of community structure may be useful for regulating energy balance in obese individuals.
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Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Daniel N. Frank,Allison L. St. Amand,Robert A. Feldman,Edgar C. Boedeker,Noam Harpaz,Norman R. Pace +5 more
TL;DR: Patient stratification by GI microbiota provides further evidence that CD represents a spectrum of disease states and suggests that treatment of some forms of IBD may be facilitated by redress of the detected microbiological imbalances.