Open Access
Supplementary Materials for Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut
Sebastian E. Winter,Maria G. Winter,Mariana N. Xavier,A. Marijke Keestra,Richard Laughlin,Gabriel Gomez,Jing Wu,Ina Popova,Sanjai J. Parikh,L. Garry Adams,Renée M. Tsolis,Andreas J. Bäumler +11 more
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The article was published on 2013-01-01 and is currently open access. It has received 505 citations till now.read more
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Low mutational load and high mutation rate variation in gut commensal bacteria.
TL;DR: Following the long-term evolution of commensal Escherichia coli in the mouse gut, the emergence of mutation rate polymorphism is observed, ranging from wild-type levels to 1,000-fold higher, suggesting that key evolutionary processes shaping the genetic composition of this community have been identified.
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Understanding Host-Adherent-Invasive Escherichia coli Interaction in Crohn's Disease: Opening Up New Therapeutic Strategies
TL;DR: The importance of adherent-invasive Escherichia coli as triggers of intestinal inflammation, focusing on their impact on epithelial barrier function and stimulation of mucosal inflammation is reported.
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Dysbiosis of lower respiratory tract microbiome are associated with inflammation and microbial function variety
TL;DR: The results suggested that smoking had markedly effects on the microbiota structure of lower respiratory tract based on Bray-Curtis distance and on unweighted uniFrac distance, and found that smoking increased the abundance of Acinetobacter, Bacillus and Staphylococcus, which were defined as pathogenic bacteria.
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Avian Influenza Virus Subtype H9N2 Affects Intestinal Microbiota, Barrier Structure Injury, and Inflammatory Intestinal Disease in the Chicken Ileum.
Hongxin Li,Xiaolin Liu,Feiyang Chen,Kejing Zuo,Che Wu,Yiming Yan,Weiguo Chen,Wencheng Lin,Qingmei Xie +8 more
TL;DR: It was found that H9N2 AIV caused intestinal microbiota disorder, injury, and inflammatory damage to the intestinal mucosa, and the mRNA expression of proinflammatory cytokines in intestinal epithelial cells were significantly upregulated, resulting in the inflammatory response and intestinal injury.
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Colon Carcinogenesis: The Interplay Between Diet and Gut Microbiota
TL;DR: Dietary intervention and gut microbiota modulation may play a vital role in reducing CRC risk, and the role of proteins, carbohydrates, fat, and their end products are considered as part of the interplay between diet and Gut microbiota.
References
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One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
TL;DR: A simple and highly efficient method to disrupt chromosomal genes in Escherichia coli in which PCR primers provide the homology to the targeted gene(s), which should be widely useful, especially in genome analysis of E. coli and other bacteria.
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A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in Gram negative bacteria
TL;DR: In this paper, a new vector strategy for the insertion of foreign genes into the genomes of gram negative bacteria not closely related to Escherichia coli was developed, which can utilize any gram negative bacterium as a recipient for conjugative DNA transfer.
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Diversity of the human intestinal microbial flora.
Paul B. Eckburg,Elisabeth M. Bik,Charles N. Bernstein,Elizabeth Purdom,Les Dethlefsen,Michael Sargent,Steven R. Gill,Karen E. Nelson,David A. Relman,David A. Relman,David A. Relman +10 more
TL;DR: A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered.
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Obesity alters gut microbial ecology
Ruth E. Ley,Fredrik Bäckhed,Peter J. Turnbaugh,Catherine A. Lozupone,Robin D. Knight,Jeffrey I. Gordon +5 more
TL;DR: Analysis of the microbiota of genetically obese ob/ob mice, lean ob/+ and wild-type siblings, and their ob/+ mothers, all fed the same polysaccharide-rich diet, indicates that obesity affects the diversity of the gut microbiota and suggests that intentional manipulation of community structure may be useful for regulating energy balance in obese individuals.
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Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Daniel N. Frank,Allison L. St. Amand,Robert A. Feldman,Edgar C. Boedeker,Noam Harpaz,Norman R. Pace +5 more
TL;DR: Patient stratification by GI microbiota provides further evidence that CD represents a spectrum of disease states and suggests that treatment of some forms of IBD may be facilitated by redress of the detected microbiological imbalances.