Open Access
Supplementary Materials for Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut
Sebastian E. Winter,Maria G. Winter,Mariana N. Xavier,A. Marijke Keestra,Richard Laughlin,Gabriel Gomez,Jing Wu,Ina Popova,Sanjai J. Parikh,L. Garry Adams,Renée M. Tsolis,Andreas J. Bäumler +11 more
About:
The article was published on 2013-01-01 and is currently open access. It has received 505 citations till now.read more
Citations
More filters
Book ChapterDOI
Microbiome in the Critically Ill
TL;DR: The authors are just beginning to understand the role of the microbiome in health and disease, and can modify the microbiome with probiotics, although the science of doing so is still undeveloped.
Book ChapterDOI
Mouse Models of Chronic Intestinal Inflammation: Characterization and Use in Pharmacological Intervention Studies
TL;DR: This chapter presents a critical evaluation of selected mouse models of IBD and discusses their utility in preclinical studies, and describes recent advances in generating and utilizing “humanized” mice to study the pathogenesis and treatment of chronic gut inflammation.
Role of the Interleukin-22 and STAT3 Signaling Pathway in Gut Barrier Maintenance Following Intoxication and Burn Injury
TL;DR: The results indicate that alcohol and burn injury affects tight junction and mucin expression in the small and large intestines, which may be mediated through local changes in the intestinal microbiome, leading to the development of gut barrier leakiness following alcohol andBurn injury.
Journal ArticleDOI
Metatax: Metataxonomics with a Compi-Based Pipeline for Precision Medicine
Osvaldo Graña-Castro,Hugo López-Fernández,Alba Nogueira-Rodríguez,Florentino Fdez-Riverola,Fatima Al-Shahrour,Daniel Glez-Peña +5 more
TL;DR: Metatax, a new pipeline to analyze biological samples based on 16S rRNA gene sequencing, is implemented, which should complement those obtained by sequencing a patient's DNA and RNA, in addition to clinical data to improve knowledge of the possible reasons for a disease or a worse response to treatment.
References
More filters
Journal ArticleDOI
One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
TL;DR: A simple and highly efficient method to disrupt chromosomal genes in Escherichia coli in which PCR primers provide the homology to the targeted gene(s), which should be widely useful, especially in genome analysis of E. coli and other bacteria.
Journal ArticleDOI
A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in Gram negative bacteria
TL;DR: In this paper, a new vector strategy for the insertion of foreign genes into the genomes of gram negative bacteria not closely related to Escherichia coli was developed, which can utilize any gram negative bacterium as a recipient for conjugative DNA transfer.
Journal ArticleDOI
Diversity of the human intestinal microbial flora.
Paul B. Eckburg,Elisabeth M. Bik,Charles N. Bernstein,Elizabeth Purdom,Les Dethlefsen,Michael Sargent,Steven R. Gill,Karen E. Nelson,David A. Relman,David A. Relman,David A. Relman +10 more
TL;DR: A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered.
Journal ArticleDOI
Obesity alters gut microbial ecology
Ruth E. Ley,Fredrik Bäckhed,Peter J. Turnbaugh,Catherine A. Lozupone,Robin D. Knight,Jeffrey I. Gordon +5 more
TL;DR: Analysis of the microbiota of genetically obese ob/ob mice, lean ob/+ and wild-type siblings, and their ob/+ mothers, all fed the same polysaccharide-rich diet, indicates that obesity affects the diversity of the gut microbiota and suggests that intentional manipulation of community structure may be useful for regulating energy balance in obese individuals.
Journal ArticleDOI
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Daniel N. Frank,Allison L. St. Amand,Robert A. Feldman,Edgar C. Boedeker,Noam Harpaz,Norman R. Pace +5 more
TL;DR: Patient stratification by GI microbiota provides further evidence that CD represents a spectrum of disease states and suggests that treatment of some forms of IBD may be facilitated by redress of the detected microbiological imbalances.