Open Access
Supplementary Materials for Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut
Sebastian E. Winter,Maria G. Winter,Mariana N. Xavier,A. Marijke Keestra,Richard Laughlin,Gabriel Gomez,Jing Wu,Ina Popova,Sanjai J. Parikh,L. Garry Adams,Renée M. Tsolis,Andreas J. Bäumler +11 more
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The article was published on 2013-01-01 and is currently open access. It has received 505 citations till now.read more
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Dysbiosis in the inflamed intestine: Chance favors the prepared microbe
TL;DR: Evidence is reviewed that the local inflammatory response creates a unique nutritional environment that is conducive to a bloom of bacterial species whose genomes encode the capability of utilizing inflammation-derived nutrients.
Journal ArticleDOI
Salmonella Uses Energy Taxis to Benefit from Intestinal Inflammation
Fabian Rivera-Chávez,Sebastian E. Winter,Christopher A. Lopez,Mariana N. Xavier,Maria G. Winter,Sean Paul Nuccio,Joseph M. Russell,Richard Laughlin,Sara D. Lawhon,Torsten Sterzenbach,Charles L. Bevins,Renée M. Tsolis,Rasika M. Harshey,L. Garry Adams,Andreas J. Bäumler +14 more
TL;DR: It is suggested that the energy taxis receptors Tsr and Aer respond to distinct in vivo signals to confer a fitness advantage upon S. Typhimurium during inflammation by enabling this facultative anaerobic pathogen to seek out favorable spatial niches containing host-derived electron acceptors that boost its luminal growth.
Journal ArticleDOI
Metabolic crosstalk between host and pathogen: sensing, adapting and competing
TL;DR: This Review focuses on host–pathogen interactions at the metabolic level: chemical signalling events that enable pathogens to sense anatomical location and the local physiology of the host; microbial metabolic pathways that are dedicated to circumvent host immune mechanisms; and a few metabolites as central points of competition between the host and bacterial pathogens.
Journal ArticleDOI
Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms.
Destanie R. Rose,Houa Yang,Gloria Serena,Craig Sturgeon,Bing Ma,Milo Careaga,Heather K. Hughes,Kathy Angkustsiri,Melissa Rose,Irva Hertz-Picciotto,Judy Van de Water,Robin L Hansen,Jacques Ravel,Alessio Fasano,Paul Ashwood +14 more
TL;DR: It is suggested that children with ASD who experience GI symptoms have an imbalance in their immune response, possibly influenced by or influencing metagenomic changes, and may have a propensity to impaired gut barrier function which may contribute to their symptoms and clinical outcome.
Journal ArticleDOI
Use of 16S rRNA Gene-Targeted Group-Specific Primers for Real-Time PCR Analysis of Predominant Bacteria in Mouse Feces
Yunwen Yang,Mang-Kun Chen,Bingya Yang,Xian-Jie Huang,Xuerui Zhang,Liangqiang He,Jing Zhang,Zi-Chun Hua +7 more
TL;DR: The set of primers developed in this study provides a simple and affordable method to monitor changes in the intestinal microbiota at the phylum level and efficiently predicted the occurrence of colitis, such as spontaneous chronic inflammatory bowel disease in transgenic mice.
References
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One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
TL;DR: A simple and highly efficient method to disrupt chromosomal genes in Escherichia coli in which PCR primers provide the homology to the targeted gene(s), which should be widely useful, especially in genome analysis of E. coli and other bacteria.
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A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in Gram negative bacteria
TL;DR: In this paper, a new vector strategy for the insertion of foreign genes into the genomes of gram negative bacteria not closely related to Escherichia coli was developed, which can utilize any gram negative bacterium as a recipient for conjugative DNA transfer.
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Paul B. Eckburg,Elisabeth M. Bik,Charles N. Bernstein,Elizabeth Purdom,Les Dethlefsen,Michael Sargent,Steven R. Gill,Karen E. Nelson,David A. Relman,David A. Relman,David A. Relman +10 more
TL;DR: A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered.
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Obesity alters gut microbial ecology
Ruth E. Ley,Fredrik Bäckhed,Peter J. Turnbaugh,Catherine A. Lozupone,Robin D. Knight,Jeffrey I. Gordon +5 more
TL;DR: Analysis of the microbiota of genetically obese ob/ob mice, lean ob/+ and wild-type siblings, and their ob/+ mothers, all fed the same polysaccharide-rich diet, indicates that obesity affects the diversity of the gut microbiota and suggests that intentional manipulation of community structure may be useful for regulating energy balance in obese individuals.
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Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Daniel N. Frank,Allison L. St. Amand,Robert A. Feldman,Edgar C. Boedeker,Noam Harpaz,Norman R. Pace +5 more
TL;DR: Patient stratification by GI microbiota provides further evidence that CD represents a spectrum of disease states and suggests that treatment of some forms of IBD may be facilitated by redress of the detected microbiological imbalances.