Open Access
Supplementary Materials for Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut
Sebastian E. Winter,Maria G. Winter,Mariana N. Xavier,A. Marijke Keestra,Richard Laughlin,Gabriel Gomez,Jing Wu,Ina Popova,Sanjai J. Parikh,L. Garry Adams,Renée M. Tsolis,Andreas J. Bäumler +11 more
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The article was published on 2013-01-01 and is currently open access. It has received 505 citations till now.read more
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The Intestinal Epithelium: Central Coordinator of Mucosal Immunity.
Joannie M. Allaire,Shauna M. Crowley,H. T. Law,Sun-Young Chang,Hyun-Jeong Ko,Bruce A. Vallance +5 more
TL;DR: Recent findings regarding communication between microbes and intestinal epithelial cells (IECs), as well as the immune mechanisms employed by distinct IEC subsets to promote homeostasis are highlighted, emphasizing the central and active role that these cells play in host enteric defense.
Journal ArticleDOI
Gut Microbiota Dysbiosis in Postweaning Piglets: Understanding the Keys to Health
Raphaële Gresse,Frédérique Chaucheyras-Durand,Mickaël Alain Fleury,Tom Van de Wiele,Evelyne Forano,Stéphanie Blanquet-Diot +5 more
TL;DR: Nonantimicrobial alternatives, such as zinc oxide, essential oils, and prebiotics or probiotics, which are currently evaluated to restore intestinal balance and allow a better management of the crucial weaning transition are focused on.
Journal ArticleDOI
Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature
Yael Haberman,Timothy L. Tickle,Phillip J. Dexheimer,Mi-Ok Kim,Dora Tang,Rebekah Karns,Robert N. Baldassano,Joshua D. Noe,Joel R. Rosh,James Markowitz,Melvin B. Heyman,Anne M. Griffiths,Wallace Crandall,David R. Mack,Susan S. Baker,Curtis Huttenhower,David J. Keljo,Jeffrey S. Hyams,Subramaniam Kugathasan,Thomas D. Walters,Bruce J. Aronow,Ramnik J. Xavier,Dirk Gevers,Lee A. Denson +23 more
TL;DR: These CD-specific host and microbe profiles identify the ileum as the primary inductive site for all forms of CD and may direct prognostic and therapeutic approaches.
Journal ArticleDOI
Recovery of gut microbiota of healthy adults following antibiotic exposure
Albert Pallejà,Kristian Hallundbæk Mikkelsen,Sofia K. Forslund,Alireza Kashani,Kristine H. Allin,Kristine H. Allin,Trine Nielsen,Tue H. Hansen,Suisha Liang,Qiang Feng,Chenchen Zhang,Paul Theodor Pyl,Luis Pedro Coelho,Huanming Yang,Jian Wang,Athanasios Typas,Morten Frost Munk Nielsen,Henrik Nielsen,Peer Bork,Jun Wang,Tina Vilsbøll,Torben Hansen,Torben Hansen,Filip K. Knop,Manimozhiyan Arumugam,Oluf Pedersen +25 more
TL;DR: It is shown that the human gut microbiome can recover after a clinically relevant, broad-spectrum antibiotic treatment and characterization of the resistome indicates that antibiotic resistance genes can impact the recovery process.
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The outer mucus layer hosts a distinct intestinal microbial niche
Hai Li,Julien P. Limenitakis,Tobias Fuhrer,Markus B. Geuking,Melissa A. E. Lawson,Madeleine Wyss,Sandrine Brugiroux,Irene Keller,Jamie A. Macpherson,Sandra Rupp,Bettina Stolp,Jens V. Stein,Bärbel Stecher,Uwe Sauer,Kathleen McCoy,Andrew J. Macpherson +15 more
TL;DR: It is shown that the outer mucus of the large intestine forms a unique microbial niche with distinct communities, including bacteria without specialized mucolytic capability, and bacterial species present in the mucus show differential proliferation and resource utilization compared with the same species in the intestinal lumen.
References
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One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
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A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in Gram negative bacteria
TL;DR: In this paper, a new vector strategy for the insertion of foreign genes into the genomes of gram negative bacteria not closely related to Escherichia coli was developed, which can utilize any gram negative bacterium as a recipient for conjugative DNA transfer.
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Paul B. Eckburg,Elisabeth M. Bik,Charles N. Bernstein,Elizabeth Purdom,Les Dethlefsen,Michael Sargent,Steven R. Gill,Karen E. Nelson,David A. Relman,David A. Relman,David A. Relman +10 more
TL;DR: A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered.
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Obesity alters gut microbial ecology
Ruth E. Ley,Fredrik Bäckhed,Peter J. Turnbaugh,Catherine A. Lozupone,Robin D. Knight,Jeffrey I. Gordon +5 more
TL;DR: Analysis of the microbiota of genetically obese ob/ob mice, lean ob/+ and wild-type siblings, and their ob/+ mothers, all fed the same polysaccharide-rich diet, indicates that obesity affects the diversity of the gut microbiota and suggests that intentional manipulation of community structure may be useful for regulating energy balance in obese individuals.
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Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Daniel N. Frank,Allison L. St. Amand,Robert A. Feldman,Edgar C. Boedeker,Noam Harpaz,Norman R. Pace +5 more
TL;DR: Patient stratification by GI microbiota provides further evidence that CD represents a spectrum of disease states and suggests that treatment of some forms of IBD may be facilitated by redress of the detected microbiological imbalances.