Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell.
Maritza Puray-Chavez,Kyle M. LaPak,Travis P. Schrank,Jennifer L Elliott,Dhaval P. Bhatt,Megan J. Agajanian,Ria Jasuja,Dana Q. Lawson,Keanu Davis,Paul W. Rothlauf,Paul W. Rothlauf,Zhuoming Liu,Heejoon Jo,Nakyung Lee,Kasyap Tenneti,Jenna E. Eschbach,Christian Shema Mugisha,Emily M. Cousins,Erica W. Cloer,Hung R. Vuong,Laura A. VanBlargan,Adam L. Bailey,Pavlo Gilchuk,James E. Crowe,Michael S. Diamond,D. Neil Hayes,Sean P. J. Whelan,Amjad Horani,Steven L. Brody,Dennis Goldfarb,M. Ben Major,Sebla B. Kutluay +31 more
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TLDR
In this article, the authors identify human H522 lung adenocarcinoma cells as naturally permissive to SARS-CoV-2 infection despite complete absence of angiotensin-converting enzyme 2 (ACE2) expression.About:
This article is published in Cell Reports.The article was published on 2021-07-13 and is currently open access. It has received 87 citations till now. The article focuses on the topics: Tropism & Interferon.read more
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Bat coronaviruses related to SARS-CoV-2 and infectious for human cells
Sarah Temmam,Khamsing Vongphayloth,Eduard Baquero,Sandie Munier,Massimiliano Bonomi,Béatrice Regnault,Bounsavane Douangboubpha,Yasaman Karami,Delphine Chrétien,Daosavanh Sanamxay,Vilakhan Xayaphet,Phetphoumin Paphaphanh,Vincent Lacoste,Somphavanh Somlor,Khaithong Lakeomany,Nothasin Phommavanh,Philippe Pérot,Océane Dehan,Faustine Amara,Flora Donati,Thomas Bigot,Michael Nilges,Félix A. Rey,S. Van Der Werf,Paul T. Brey,Marc Eloit +25 more
TL;DR: In this article , the authors show that SARS-CoV-2-like viruses can infect human cells through the ACE2 pathway in cave bats living in the limestone karstic terrain in northern Laos, in the Indochinese peninsula.
Journal ArticleDOI
SARS-CoV-2 Variants, Vaccines, and Host Immunity
Priyal Mistry,Fatima Barmania,Juanita Mellet,Kimberly Thando Peta,A. Strydom,Ignatius M. Viljoen,William James,Siamon Gordon,Michael S. Pepper +8 more
TL;DR: In this article , the authors reviewed both SARS-CoV-2-induced host immune activation and vaccine-induced immune responses, highlighting the responses of immune memory cells that are key indicators of host immunity.
Journal ArticleDOI
SARS-CoV-2 Alpha, Beta, and Delta variants display enhanced Spike-mediated syncytia formation.
Maaran Michael Rajah,Maaran Michael Rajah,Mathieu Hubert,Elodie Bishop,Elodie Bishop,Nell Saunders,Rémy Robinot,Ludivine Grzelak,Ludivine Grzelak,Delphine Planas,Jérémy Dufloo,Jérémy Dufloo,Stacy Gellenoncourt,Stacy Gellenoncourt,Alice Bongers,Alice Bongers,Marija Zivaljic,Marija Zivaljic,Cyril Planchais,Florence Guivel-Benhassine,Françoise Porrot,Hugo Mouquet,Lisa A. Chakrabarti,Julian Buchrieser,Olivier Schwartz,Olivier Schwartz +25 more
TL;DR: In this paper, the SARS-CoV-2 spike protein expressed on the surface of infected cells interacts with the ACE2 receptor on neighboring cells, and the syncytia forming potential of spike variant proteins remain poorly characterized.
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Cellular host factors for SARS-CoV-2 infection.
TL;DR: In this article, the authors summarized insights into the proviral host factors that are required for SARS-CoV-2 infection that were mainly obtained using functional genetic and interactome screens.
Journal ArticleDOI
The Mechanism and Consequences of SARS-CoV-2 Spike-Mediated Fusion and Syncytia Formation.
Maaran Michael Rajah,Ana Cristina Gallego-Hernández,Maaran Michael Rajah,Annie Bernier,Julian Buchrieser,Olivier Schwartz,Olivier Schwartz +6 more
TL;DR: In this article, the authors discuss the molecular determinants of S mediated fusion and the antiviral innate immunity components that counteract syncytia formation in SARS-CoV-2 infection and pathology.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.
TL;DR: EdgeR as mentioned in this paper is a Bioconductor software package for examining differential expression of replicated count data, which uses an overdispersed Poisson model to account for both biological and technical variability and empirical Bayes methods are used to moderate the degree of overdispersion across transcripts, improving the reliability of inference.
Journal ArticleDOI
limma powers differential expression analyses for RNA-sequencing and microarray studies
Matthew E. Ritchie,Belinda Phipson,Di Wu,Yifang Hu,Charity W. Law,Wei Shi,Gordon K. Smyth,Gordon K. Smyth +7 more
TL;DR: The philosophy and design of the limma package is reviewed, summarizing both new and historical features, with an emphasis on recent enhancements and features that have not been previously described.
Journal ArticleDOI
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
TL;DR: An R package, clusterProfiler that automates the process of biological-term classification and the enrichment analysis of gene clusters and can be easily extended to other species and ontologies is presented.
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