The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries
Erich A. Nigg,Tim Stearns +1 more
Reads0
Chats0
TLDR
The spatial aspects of the centrosome duplication cycle, the mechanism of centriole assembly and the possible consequences of the inherent asymmetry of Centrosomes and centrosomes are discussed.Abstract:
Centrosomes are microtubule-organizing centres of animal cells. They influence the morphology of the microtubule cytoskeleton, function as the base for the primary cilium and serve as a nexus for important signalling pathways. At the core of a typical centrosome are two cylindrical microtubule-based structures termed centrioles, which recruit a matrix of associated pericentriolar material. Cells begin the cell cycle with exactly one centrosome, and the duplication of centrioles is constrained such that it occurs only once per cell cycle and at a specific site in the cell. As a result of this duplication mechanism, the two centrioles differ in age and maturity, and thus have different functions; for example, the older of the two centrioles can initiate the formation of a ciliary axoneme. We discuss spatial aspects of the centrosome duplication cycle, the mechanism of centriole assembly and the possible consequences of the inherent asymmetry of centrioles and centrosomes.read more
Citations
More filters
Journal ArticleDOI
Centrosomal-associated Proteins: Potential therapeutic targets for solid tumors?
TL;DR: The centrosome is a special organelle in human cells and an organizing unit for microtubules and signaling molecules, and it forms the basal body of the cilia in ciliated cells.
Journal ArticleDOI
The Role of DAPK1 in the Cell Cycle Regulation of Cervical Cancer Cells and in Response to Topotecan
TL;DR: In this paper , the cell cycle roles of DAPK1 and PLK1 in cervical cancer cells were explored, and it was shown that the enzyme activity of the enzyme was regulated in a cell cycle-specific manner.
Journal ArticleDOI
Ciliopathic micrognathia is caused by aberrant skeletal differentiation and remodeling.
Christian Louis Bonatto Paese,Evan C. Brooks,Megan Aarnio-Peterson,Samantha A. Brugmann,Samantha A. Brugmann +4 more
TL;DR: In this paper, a bona fide avian model for the human ciliopathy oral-facial-digital syndrome subtype 14 was used to understand the cellular and molecular basis for ciliopathic micrognathia.
Journal ArticleDOI
C3G localizes to the mother centriole in a cenexin-dependent manner and regulates centrosome duplication and primary cilium length.
TL;DR: It is concluded that C3G regulates centrosome duplication and maintains ciliary homeostasis, properties that could be important for its role in embryonic development.
Journal ArticleDOI
Chemical tools for dissecting cell division.
TL;DR: Recent progress in small-molecule probes used to address questions in cell division are summarized and some emerging techniques that can be adapted to cell division studies are appraised.
References
More filters
Journal ArticleDOI
The primary cilium: a signalling centre during vertebrate development
TL;DR: The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction, and the cilium represents a nexus for signalling pathways during development.
Journal ArticleDOI
A Mechanism Linking Extra Centrosomes to Chromosomal Instability
TL;DR: It is demonstrated that cells with multiple centrosomes rarely undergo multipolar cell divisions, and the progeny of these divisions are typically inviable, and it is proposed that this mechanism may be a common underlying cause of CIN in human cancer.
Journal ArticleDOI
Proteomic characterization of the human centrosome by protein correlation profiling
Jens S. Andersen,Christopher J. Wilkinson,Thibault Mayor,Thibault Mayor,Peter Mortensen,Erich A. Nigg,Matthias Mann +6 more
TL;DR: A mass-spectrometry-based proteomic analysis of human centrosomes in the interphase of the cell cycle by quantitatively profiling hundreds of proteins across several centrifugation fractions identified and validated 23 novel components and identified 41 likely candidates as well as the vast majority of the known centrosomal proteins in a large background of nonspecific proteins.
Journal ArticleDOI
Hippo signaling: growth control and beyond
Georg Halder,Randy L. Johnson +1 more
TL;DR: Recently discovered mechanisms that contribute to the dynamic regulation of Hippo signaling during Drosophila and vertebrate development are reviewed and exciting new insights are provided into the elusive mechanisms that regulate organ growth and regeneration.
Journal ArticleDOI
Cleavage of Cohesin by the CD Clan Protease Separin Triggers Anaphase in Yeast
TL;DR: It is shown here that separin is a cysteine protease related to caspases that alone can cleave Sccl in vitro and depends on a conserved protein called separin for sister chromatid separation.