The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries
Erich A. Nigg,Tim Stearns +1 more
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TLDR
The spatial aspects of the centrosome duplication cycle, the mechanism of centriole assembly and the possible consequences of the inherent asymmetry of Centrosomes and centrosomes are discussed.Abstract:
Centrosomes are microtubule-organizing centres of animal cells. They influence the morphology of the microtubule cytoskeleton, function as the base for the primary cilium and serve as a nexus for important signalling pathways. At the core of a typical centrosome are two cylindrical microtubule-based structures termed centrioles, which recruit a matrix of associated pericentriolar material. Cells begin the cell cycle with exactly one centrosome, and the duplication of centrioles is constrained such that it occurs only once per cell cycle and at a specific site in the cell. As a result of this duplication mechanism, the two centrioles differ in age and maturity, and thus have different functions; for example, the older of the two centrioles can initiate the formation of a ciliary axoneme. We discuss spatial aspects of the centrosome duplication cycle, the mechanism of centriole assembly and the possible consequences of the inherent asymmetry of centrioles and centrosomes.read more
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Intracellular Scaling Mechanisms
Simone Reber,Nathan W. Goehring +1 more
TL;DR: This work highlights scaling mechanisms for cellular structures as diverse as centrosomes, nuclei, and the mitotic spindle, and distinguish them from more general mechanisms of size control.
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Parental centrioles are dispensable for deuterosome formation and function during basal body amplification.
Huijie Zhao,Qingxia Chen,Chuyu Fang,Qiongping Huang,Jun Zhou,Xiumin Yan,Xueliang Zhu,Xueliang Zhu +7 more
TL;DR: It is shown that both parental centrioles are dispensable for deuterosome formation and can be assembled autonomously to mediate de novo centriole amplification in multiciliated cells.
Journal ArticleDOI
DISC1 A Key Lead in Studying Cortical Development and Associated Brain Disorders
TL;DR: The significance of DISC1 in forming an overall understanding of multiple mechanisms that orchestrate corticogenesis and can serve as therapeutic targets in diseases caused by abnormal cortical development is discussed.
Journal ArticleDOI
Talpid3-binding centrosomal protein Cep120 is required for centriole duplication and proliferation of cerebellar granule neuron progenitors.
TL;DR: Cell biological studies show that the loss of Cep120 results in failed centriole duplication and consequently ciliogenesis, which together underlie Cep 120 mutant cerebellar hypoplasia, which for the first time links a centrosomal protein necessary for centrioles duplication to cerebellary morphogenesis.
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C-Nap1 mutation affects centriole cohesion and is associated with a Seckel-like syndrome in cattle
Sandrine Floriot,Christine Vesque,Sabrina Rodriguez,Florence Bourgain-Guglielmetti,Anthi Karaiskou,Mathieu Gautier,Amandine Duchesne,Sarah Barbey,Sébastien Fritz,Alexandre Vasilescu,Maud Bertaud,Mohammed Moudjou,Sophie Halliez,Valérie Cormier-Daire,Joyce El Hokayem,Erich A. Nigg,Luc Manciaux,Raphaël Guatteo,Nora Cesbron,Geraldine Toutirais,André Eggen,Sylvie Schneider-Maunoury,Didier Boichard,Joëlle Sobczak-Thépot,Laurent Schibler +24 more
TL;DR: It is shown that caprine-like Generalized Hypoplasia Syndrome is caused by a truncating mutation in the CEP250 gene that encodes the centrosomal protein C-Nap1, which extends the range of loci that constitute the spectrum of autosomal primary recessive microcephaly (MCPH) and Seckel-like syndromes.
References
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TL;DR: The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction, and the cilium represents a nexus for signalling pathways during development.
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A Mechanism Linking Extra Centrosomes to Chromosomal Instability
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Proteomic characterization of the human centrosome by protein correlation profiling
Jens S. Andersen,Christopher J. Wilkinson,Thibault Mayor,Thibault Mayor,Peter Mortensen,Erich A. Nigg,Matthias Mann +6 more
TL;DR: A mass-spectrometry-based proteomic analysis of human centrosomes in the interphase of the cell cycle by quantitatively profiling hundreds of proteins across several centrifugation fractions identified and validated 23 novel components and identified 41 likely candidates as well as the vast majority of the known centrosomal proteins in a large background of nonspecific proteins.
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Hippo signaling: growth control and beyond
Georg Halder,Randy L. Johnson +1 more
TL;DR: Recently discovered mechanisms that contribute to the dynamic regulation of Hippo signaling during Drosophila and vertebrate development are reviewed and exciting new insights are provided into the elusive mechanisms that regulate organ growth and regeneration.
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Cleavage of Cohesin by the CD Clan Protease Separin Triggers Anaphase in Yeast
TL;DR: It is shown here that separin is a cysteine protease related to caspases that alone can cleave Sccl in vitro and depends on a conserved protein called separin for sister chromatid separation.