The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries
Erich A. Nigg,Tim Stearns +1 more
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TLDR
The spatial aspects of the centrosome duplication cycle, the mechanism of centriole assembly and the possible consequences of the inherent asymmetry of Centrosomes and centrosomes are discussed.Abstract:
Centrosomes are microtubule-organizing centres of animal cells. They influence the morphology of the microtubule cytoskeleton, function as the base for the primary cilium and serve as a nexus for important signalling pathways. At the core of a typical centrosome are two cylindrical microtubule-based structures termed centrioles, which recruit a matrix of associated pericentriolar material. Cells begin the cell cycle with exactly one centrosome, and the duplication of centrioles is constrained such that it occurs only once per cell cycle and at a specific site in the cell. As a result of this duplication mechanism, the two centrioles differ in age and maturity, and thus have different functions; for example, the older of the two centrioles can initiate the formation of a ciliary axoneme. We discuss spatial aspects of the centrosome duplication cycle, the mechanism of centriole assembly and the possible consequences of the inherent asymmetry of centrioles and centrosomes.read more
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Journal ArticleDOI
The centrosome protein AKNA regulates neurogenesis via microtubule organization
Germán Camargo Ortega,Sven Falk,Pia A Johansson,Pia A Johansson,Elise Peyre,Loïc Broix,Sanjeeb Kumar Sahu,William G. Hirst,William G. Hirst,Thomas Schlichthaerle,Thomas Schlichthaerle,Camino de Juan Romero,Kalina Draganova,Stanislav Vinopal,Kaviya Chinnappa,Anna Gavranovic,Tugay Karakaya,Thomas Steininger,Juliane Merl-Pham,Regina Feederle,Wei Shao,Wei Shao,Song-Hai Shi,Song-Hai Shi,Stefanie M. Hauck,Ralf Jungmann,Ralf Jungmann,Frank Bradke,Víctor Borrell,Arie Geerlof,Simone Reber,Simone Reber,Vijay K. Tiwari,Wieland B. Huttner,Michaela Wilsch-Bräuninger,Laurent Nguyen,Magdalena Götz +36 more
TL;DR: The interphase centrosome protein AKNA is necessary and sufficient for the organization of centrosomal microtubules, mediates delamination in the formation of the subventricular zone and regulates exit from this zone, and the epithelial-to-mesenchymal transition is regulated by AKNA in other epithelial cells, demonstrating its general importance for the control of cell delamination.
Journal ArticleDOI
M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole.
TL;DR: It is shown that M-Phase Phosphoprotein 9 (MPP9) is recruited by Kinesin Family Member 24 (KIF24) to the distal end of mother centriole where it forms a ring-like structure and recruits CP110-CEP97 by directly binding CEP97.
Book ChapterDOI
The cardiomyocyte cell cycle in hypertrophy, tissue homeostasis, and regeneration.
TL;DR: The result of cardiomyocyte cell cycle activity in aging and disease and studies manipulating cardiac cell cycleActivity to promote cardiac regeneration are discussed and the relationship between ploidy and regenerative potential is focused on.
Journal ArticleDOI
Primary Cilium in Cancer Hallmarks.
TL;DR: The current knowledge about the influence of the primary cilium in cancer progression is described, with a focus on some of the events that cancers need to face to sustain survival and growth in hypoxic microenvironment: the cancer hallmarks.
Journal ArticleDOI
Mechanisms of ciliogenesis suppression in dividing cells.
TL;DR: The current knowledge of how cycling cells suppress ciliogenesis is summarized and compared with mechanisms underlying ciliary resorption after cell-cycle reentry to discuss a reciprocal relationship between primary cilia and cell proliferation.
References
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Journal ArticleDOI
The primary cilium: a signalling centre during vertebrate development
TL;DR: The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction, and the cilium represents a nexus for signalling pathways during development.
Journal ArticleDOI
A Mechanism Linking Extra Centrosomes to Chromosomal Instability
TL;DR: It is demonstrated that cells with multiple centrosomes rarely undergo multipolar cell divisions, and the progeny of these divisions are typically inviable, and it is proposed that this mechanism may be a common underlying cause of CIN in human cancer.
Journal ArticleDOI
Proteomic characterization of the human centrosome by protein correlation profiling
Jens S. Andersen,Christopher J. Wilkinson,Thibault Mayor,Thibault Mayor,Peter Mortensen,Erich A. Nigg,Matthias Mann +6 more
TL;DR: A mass-spectrometry-based proteomic analysis of human centrosomes in the interphase of the cell cycle by quantitatively profiling hundreds of proteins across several centrifugation fractions identified and validated 23 novel components and identified 41 likely candidates as well as the vast majority of the known centrosomal proteins in a large background of nonspecific proteins.
Journal ArticleDOI
Hippo signaling: growth control and beyond
Georg Halder,Randy L. Johnson +1 more
TL;DR: Recently discovered mechanisms that contribute to the dynamic regulation of Hippo signaling during Drosophila and vertebrate development are reviewed and exciting new insights are provided into the elusive mechanisms that regulate organ growth and regeneration.
Journal ArticleDOI
Cleavage of Cohesin by the CD Clan Protease Separin Triggers Anaphase in Yeast
TL;DR: It is shown here that separin is a cysteine protease related to caspases that alone can cleave Sccl in vitro and depends on a conserved protein called separin for sister chromatid separation.