The immune response during acute HIV-1 infection: clues for vaccine development.
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TLDR
The finding that the first effective immune responses drive the selection of virus escape mutations provides insight into the earliest immune responses against the transmitted virus and their contributions to the control of acute viraemia.Abstract:
The early immune response to HIV-1 infection is likely to be an important factor in determining the clinical course of disease. Recent data indicate that the HIV-1 quasispecies that arise following a mucosal infection are usually derived from a single transmitted virus. Moreover, the finding that the first effective immune responses drive the selection of virus escape mutations provides insight into the earliest immune responses against the transmitted virus and their contributions to the control of acute viraemia. Strong innate and adaptive immune responses occur subsequently but they are too late to eliminate the infection. In this Review, we discuss recent studies on the kinetics and quality of early immune responses to HIV-1 and their implications for developing a successful preventive HIV-1 vaccine.read more
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The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
Florencia Pereyra,Xiaoming Jia,Paul J. McLaren,Amalio Telenti,de Bakker Pi,Bruce D. Walker,Stephan Ripke,Chanson J. Brumme,Sara L. Pulit,Mary Carrington,Carl M. Kadie,Jonathan M. Carlson,David E. Heckerman,Graham Rr,Robert M. Plenge,Steven G. Deeks,Gianniny L,Gabriel Crawford,Jean C. Sullivan,Elena Gonzalez,Davies L,Amy L. Camargo,Jamie Moore,Beattie N,Soumi Gupta,Crenshaw A,N P Burtt,Candace Guiducci,Namrata Gupta,Gao X,Qi Y,Yuko Yuki,Alicja Piechocka-Trocha,Emily Cutrell,Rachel Rosenberg,Kristin Moss,Lemay P,Jacqueline G. O'Leary,Schaefer T,Verma P,I Tóth,Brian L. Block,Brett Baker,Alissa C. Rothchild,Lian J,Jacqueline Proudfoot,Donna Marie Alvino,Seanna Vine,Marylyn M. Addo,Todd M. Allen,Marcus Altfeld,Matthew R. Henn,Le Gall S,Hendrik Streeck,David W. Haas,Daniel R. Kuritzkes,Gregory K. Robbins,Robert W. Shafer,Roy M. Gulick,Cecilia M. Shikuma,Richard Haubrich,Sharon A. Riddler,Paul E. Sax,Eric S. Daar,Heather J. Ribaudo,Brian K. Agan,Agarwal S,Ryan Ahern,Allen Bl,Altidor S,Altschuler El,Ambardar S,Kathryn Anastos,Brenna L. Anderson,Anderson,Andrady U,Antoniskis D,David R. Bangsberg,Barbaro D,Barrie W,Bartczak J,Barton S,Basden P,Nesli Basgoz,Suzane Bazner,Nicholas Bellos,Benson Am,Judith Berger,Bernard Nf,Bernard Am,Christopher E. Birch,Bodner Sj,Robert K. Bolan,Boudreaux Et,Meg Bradley,Braun Jf,Brndjar Je,Stephen J. Brown,Brown K,Sheldon T. Brown,Burack J,Bush Lm,Cafaro,Campbell O,Justin Campbell,Carlson Rh,Carmichael Jk,Casey Kk,Cavacuiti C,Celestin G,Stephen T. Chambers,Chez N,Lisa M. Chirch,Cimoch Pj,Daniel E. Cohen,Cohn Le,Brian Conway,David A. Cooper,Cornelson B,Cox Dt,Cristofano Mv,Cuchural G,Julie Czartoski,Dahman Jm,Jennifer S. Daly,Benjamin T. Davis,Kenneth L. Davis,Davod Sm,Edwin DeJesus,Craig A. Dietz,Dunham E,Dunn Me,Todd B. Ellerin,J. J. Eron,John Fangman,Farel Ce,Ferlazzo H,Sarah Fidler,Fleenor-Ford A,Frankel R,Kenneth A. Freedberg,French Nk,Jonathan D. Fuchs,Jon Fuller,Gaberman J,Joel E. Gallant,Rajesh T. Gandhi,Garcia E,Garmon D,J. Gathe,Gaultier Cr,Gebre W,Gilman Fd,Gilson I,Paul A. Goepfert,M. S. Gottlieb,Claudia Goulston,Groger Rk,Gurley Td,Haber S,Hardwicke R,W D Hardy,P. R. Harrigan,Trevor Hawkins,Sonya L. Heath,Frederick Hecht,Henry Wk,Hladek M,Hoffman Rp,James Horton,Hsu Rk,Gregory D Huhn,Peter W. Hunt,Hupert Mj,Illeman Ml,Hans Jaeger,Robert M. Jellinger,Mina John,Jennifer Johnson,Kristin Johnson,Johnson H,Kevin M. Johnson,Joly J,Wilbert C. Jordan,Carol A. Kauffman,Khanlou H,Killian Rk,Arthur Y. Kim,Kim Dd,Kinder Ca,Kirchner Jt,Laura Kogelman,Erna M. Kojic,Korthuis Pt,Kurisu W,Douglas S. Kwon,Melissa Lamar,Harry Lampiris,Lanzafame M,Michael M. Lederman,Lee Dm,Lee Jm,Lee Mj,Lee Et,Lemoine J,Jay A. Levy,Josep M. Llibre,Liguori Ma,Susan J. Little,Anne Y. Liu,Lopez Aj,Mona R. Loutfy,Loy D,Mohammed Dy,Man A,Michael K. Mansour,Vincent C. Marconi,Martin Markowitz,R. Marques,Jeffrey N. Martin,Hal Martin,Kenneth H. Mayer,MJ McElrath,McGhee Ta,Barbara H. McGovern,Katherine McGowan,McIntyre D,Mcleod Gx,Menezes P,Mesa G,Craig E. Metroka,Dirk Meyer-Olson,Miller Ao,Montgomery K,Karam Mounzer,Ellen H. Nagami,Nagin I,Nahass Rg,Nelson Mo,Nielsen C,Norene Dl,David H. O’Connor,Bisola O. Ojikutu,Jason F. Okulicz,Oladehin Oo,Oldfield Ec rd,Susan Olender,Mario A. Ostrowski,William F. Owen,Pae E,Parsonnet J,Pavlatos Am,Perlmutter Am,Pierce Mn,Pincus Jm,Pisani L,Price Lj,Laurie A. Proia,Prokesch Rc,Pujet Hc,Moti Ramgopal,Almas Rathod,Rausch M,Ravishankar J,Frank S. Rhame,Richards Cs,Douglas D. Richman,Rodes B,Rodriguez M,Rose Rc rd,Eric S. Rosenberg,Daniel I. Rosenthal,Ross Pe,Diana Rubin,Rumbaugh E,Saenz L,Michelle R Salvaggio,Sanchez Wc,Sanjana Vm,Steven Santiago,Schmidt W,Hanneke Schuitemaker,Sestak Pm,P. Shalit,Shay W,Shirvani Vn,Silebi Vi,Sizemore Jm,Paul R. Skolnik,Marcia Sokol-Anderson,James M. Sosman,Stabile P,Jack T. Stapleton,Starrett S,Stein F,Hans-Jürgen Stellbrink,Sterman Fl,Valerie E. Stone,David Stone,Giuseppe Tambussi,Randy Taplitz,Ellen Tedaldi,Theisen W,Ramon A. Torres,Tosiello L,Cécile Tremblay,Tribble Ma,Trinh Pd,Tsao A,Ueda P,Vaccaro A,Valadas E,Vanig Tj,Vecino I,Vega Vm,Veikley W,Wade Bh,Walworth C,Wanidworanun C,Doug Ward,Warner Da,Rainer Weber,Daniel P. Webster,Weis S,David Wheeler,D. White,Edmund Wilkins,Alan Winston,Wlodaver Cg,van't Wout A,Wright Dp,Otto O. Yang,Yurdin Dl,Zabukovic Bw,Kimon C. Zachary,Zeeman B,Zhao M +336 more
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