Journal ArticleDOI
The Parkinson Progression Marker Initiative (PPMI)
Kenneth Marek,Danna Jennings,Shirley Lasch,Andrew Siderowf,Caroline M. Tanner,Tanya Simuni,Christopher S. Coffey,Karl Kieburtz,Emily Flagg,Sohini Chowdhury,Werner Poewe,Brit Mollenhauer,Todd Sherer,Mark Frasier,Claire Meunier,Alice Rudolph,Cindy Casaceli,John Seibyl,Susan Mendick,Norbert Schuff,Ying Zhang,Arthur W. Toga,Karen Crawford,Alison Ansbach,Pasquale De Blasio,Michele Piovella,John Q. Trojanowski,Les Shaw,Andrew B. Singleton,Keith A. Hawkins,Jamie L. Eberling,David W. Russell,Laura Leary,Stewart A. Factor,Barbara Sommerfeld,Penelope Hogarth,Emily Pighetti,Karen Williams,David G. Standaert,Stephanie Guthrie,Robert A. Hauser,Holly Delgado,Joseph Jankovic,Christine Hunter,Matthew B. Stern,Baochan Tran,James B. Leverenz,Marne Baca,Sam Frank,Cathi A. Thomas,Irene H. Richard,Cheryl Deeley,Linda Rees,Fabienne Sprenger,Elisabeth Lang,Holly A. Shill,Sanja Obradov,Hubert H. Fernandez,Adrienna Winters,Daniela Berg,Katharina Gauss,Douglas Galasko,Deborah Fontaine,Zoltan Mari,Melissa Gerstenhaber,David J. Brooks,Sophie Malloy,Paolo Barone,Katia Longo,Tom Comery,Bernard Ravina,Igor D. Grachev,Kim Gallagher,Michelle Collins,Katherine Widnell,Suzanne Ostrowizki,Paulo Fontoura,F. Hoffmann La-Roche,Tony W. Ho,Johan Luthman,Marcel P. van der Brug,Alastair D. Reith,Peggy Taylor +82 more
TLDR
The Parkinson Progression Marker Initiative (PPMI) is a comprehensive observational, international, multi-center study designed to identify PD progression biomarkers both to improve understanding of disease etiology and course and to provide crucial tools to enhance the likelihood of success of PD modifying therapeutic trials.About:
This article is published in Progress in Neurobiology.The article was published on 2011-12-01. It has received 1269 citations till now.read more
Citations
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Journal ArticleDOI
VoxelMorph: A Learning Framework for Deformable Medical Image Registration
TL;DR: VoxelMorph promises to speed up medical image analysis and processing pipelines while facilitating novel directions in learning-based registration and its applications and demonstrates that the unsupervised model’s accuracy is comparable to the state-of-the-art methods while operating orders of magnitude faster.
Journal ArticleDOI
Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies
TL;DR: The spread of fibrillar α-synuclein pathology from the brainstem to limbic and neocortical structures seems to be the strongest neuropathological correlate of emerging dementia in Parkinson's disease.
Journal ArticleDOI
VoxelMorph: A Learning Framework for Deformable Medical Image Registration
TL;DR: Zhou et al. as mentioned in this paper proposed VoxelMorph, a fast learning-based framework for deformable, pairwise medical image registration, which parameterizes the function via a convolutional neural network and optimizes the parameters of the neural network on a set of images.
Journal ArticleDOI
Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases.
Michael D. Fox,Randy L. Buckner,Hesheng Liu,M. Mallar Chakravarty,M. Mallar Chakravarty,Andres M. Lozano,Andres M. Lozano,Alvaro Pascual-Leone +7 more
TL;DR: It is found that although different types of brain stimulation are applied in different locations, targets used to treat the same disease most often are nodes within the same brain network as defined by resting-state functional-connectivity MRI.
Journal ArticleDOI
Lead-DBS v2: Towards a comprehensive pipeline for deep brain stimulation imaging.
Andreas Horn,Ningfei Li,Till A. Dembek,Ari D Kappel,Chadwick B. Boulay,Siobhan Ewert,Anna Tietze,Andreas Husch,Thushara Perera,Wolf-Julian Neumann,Marco Reisert,Hang Si,Robert Oostenveld,Chris Rorden,Fang-Cheng Yeh,Qianqian Fang,Todd M. Herrington,Johannes Vorwerk,Andrea A. Kühn +18 more
TL;DR: This work represents a multi‐institutional collaborative effort to develop a comprehensive, open source pipeline for DBS imaging and connectomics, which has already empowered several studies, and may facilitate a variety of future studies in the field.
References
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Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Clifford R. Jack,David S. Knopman,William J. Jagust,Leslie M. Shaw,Paul S. Aisen,Michael W. Weiner,Ronald C. Petersen,John Q. Trojanowski +7 more
TL;DR: This work proposes a model that relates disease stage to AD biomarkers in which Abeta biomarkers become abnormal first, before neurodegenerative biomarkers and cognitive symptoms, and neurodegnerative biomarker become abnormal later, and correlate with clinical symptom severity.
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Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects.
Leslie M. Shaw,Hugo Vanderstichele,Malgorzata Knapik-Czajka,Christopher M. Clark,Paul S. Aisen,Ronald C. Petersen,Kaj Blennow,Holly Soares,Adam J. Simon,Piotr Lewczuk,Robert A. Dean,Eric Siemers,William Z. Potter,Virginia M.-Y. Lee,John Q. Trojanowski +14 more
TL;DR: Develop a cerebrospinal fluid biomarker signature for mild Alzheimer's disease (AD) in Alzheimer's Disease Neuroimaging Initiative (ADNI) subjects.
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Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease
W. Koller,C. W. Olanow,Robert L. Rodnitzky,J. S. Fink,J. H. Growdon,G. Paulson,Roger Kurlan,Joseph H. Friedman,S. Gancher,J. Nutt,A. H. Rajput,J. B. Bennett,G. F. Wooten,P. LeWitt,Christopher G. Goetz,C. Tanner,K. Shannon,O. Suchowersky,M. F. Brin +18 more
TL;DR: Deprenyl but not tocopherol delays the onset of disability associated with early, otherwise untreated Parkinson's disease and the action of deprenyl that accounts for its beneficial effects remains unclear.
Journal ArticleDOI
Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline.
Clifford W. Shults,David Oakes,Karl Kieburtz,M. Flint Beal,Richard H. Haas,Sandy Plumb,Jorge L. Juncos,John G. Nutt,Ira Shoulson,Julie H. Carter,Katie Kompoliti,Joel S. Perlmutter,Stephen G. Reich,Matthew B. Stern,Ray L. Watts,Roger Kurlan,Eric Molho,Madaline B. Harrison,Mark F. Lew +18 more
TL;DR: Coenzyme Q10 appears to slow the progressive deterioration of function in PD, but these results need to be confirmed in a larger study.
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Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study.
Alan L Whone,Ray L. Watts,A. Jon Stoessl,Margaret R. Davis,Sven N. Reske,Claude Nahmias,Anthony E. Lang,Olivier Rascol,Maria J Ribeiro,Philippe Remy,Werner Poewe,Robert A. Hauser,David J. Brooks +12 more
TL;DR: Ropinirole is associated with slower progression of PD than levodopa as assessed by 18F‐dopa PET, and this prospective, 2‐year, randomized, double‐blind, multinational study compared the rates of loss of dopamine‐terminal function in de novo patients with clinical and 18F-dopaPET evidence of early PD.
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