Journal ArticleDOI
Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro.
TLDR
An in vitro Fenton system was established that generates DNA strand breaks and inactivates bacteriophage and that also reproduces the suppression of DNA damage by high concentrations of peroxide.Abstract:
Exposure of Escherichia coli to low concentrations of hydrogen peroxide results in DNA damage that causes mutagenesis and kills the bacteria, whereas higher concentrations of peroxide reduce the amount of such damage. Earlier studies indicated that the direct DNA oxidant is a derivative of hydrogen peroxide whose formation is dependent on cell metabolism. The generation of this oxidant depends on the availability of both reducing equivalents and an iron species, which together mediate a Fenton reaction in which ferrous iron reduces hydrogen peroxide to a reactive radical. An in vitro Fenton system was established that generates DNA strand breaks and inactivates bacteriophage and that also reproduces the suppression of DNA damage by high concentrations of peroxide. The direct DNA oxidant both in vivo and in this in vitro system exhibits reactivity unlike that of a free hydroxyl radical and may instead be a ferryl radical.read more
Citations
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Mechanism of β-cypermethrin metabolism by Bacillus cereus GW-01
Zhao Jiayuan,Yangdan Jiang,Lanmin Gong,Xiaofeng Chen,Qingling Xie,Yan Jin,Juan Du,Shufang Wang,Gang Liu +8 more
TL;DR: In this article, a β-cypermethrin (β-CY) degrading bacterium which was isolated from a sheep's rumen chyme was identified, and it was shown that an α/β- hydrolase and a cytochrome aa3 quinol oxidase were responsible for the degradation of βCY and 3-PBA.
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Biomarkers of oxidative stress and cataract. Novel drug delivery therapeutic strategies targeting telomere reduction and the expression of telomerase activity in the lens epithelial cells with N-acetylcarnosine lubricant eye drops: anti-cataract which helps to prevent and treat cataracts in the eyes of dogs and other animals.
TL;DR: In this article, the authors showed that the therapeutic treatment with 1% N-acetylcarnosine (NAC) prodrug delivery is beneficial for prevention and dissolution of ripe cataracts in canines.
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Reactive oxygen species, calcium and serine/threonine phosphatase are required for copper-induced MAP kinase gene, OsMAPK2, expression in rice
TL;DR: It is suggested that the stimulation of OsMAPK2 transcript accumulation by copper in rice roots operates may through an intracellular signalling cascade mediated by reactive oxygen species, extracellular calcium ions and cantharidin-sensitive protein phosphatase(s).
Journal ArticleDOI
Vibrio fischeri siderophore production drives competitive exclusion during dual-species growth.
TL;DR: It is shown that cell-free culture fluids from the marine bacterium Vibrio fischeri ES114 prevent growth of other vibrio species and reveals the aerobactin siderophore as the inhibitor.
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Evaluating the Anticancer Properties of Liposomal Copper in a Nude Xenograft Mouse Model of Human Prostate Cancer: Formulation, In Vitro, In Vivo, Histology and Tissue Distribution Studies
TL;DR: LpCu was effective at reducing tumor burden in the xenograft prostate cancer model and histological evidence of Cu toxicity in kidneys and eyes of animals treated at the maximum tolerated dose of LpCu 7.0 mg/kg.
References
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Journal ArticleDOI
The biology of oxygen radicals
TL;DR: The reactive superoxide radical, O2-, formerly of concern only to radiation chemists and radiobiologists, is now understood to be a normal product of the biological reduction of molecular oxygen.
Journal ArticleDOI
The catalytic decomposition of hydrogen peroxide by iron salts
Fritz Haber,Joseph Weiss +1 more
TL;DR: Wansbrough-Jones as discussed by the authors gave the manuscript of this paper to Professor Sir William Pope, but the final revision for the press had not been made and in its original from the paper was not suitable for publication in an English journal; but since, Professor Haber had considered carefully how he wished to present the results embodied in it, the form and sequence of the paper remain unmodified.