Journal ArticleDOI
Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro.
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TLDR
An in vitro Fenton system was established that generates DNA strand breaks and inactivates bacteriophage and that also reproduces the suppression of DNA damage by high concentrations of peroxide.Abstract:
Exposure of Escherichia coli to low concentrations of hydrogen peroxide results in DNA damage that causes mutagenesis and kills the bacteria, whereas higher concentrations of peroxide reduce the amount of such damage. Earlier studies indicated that the direct DNA oxidant is a derivative of hydrogen peroxide whose formation is dependent on cell metabolism. The generation of this oxidant depends on the availability of both reducing equivalents and an iron species, which together mediate a Fenton reaction in which ferrous iron reduces hydrogen peroxide to a reactive radical. An in vitro Fenton system was established that generates DNA strand breaks and inactivates bacteriophage and that also reproduces the suppression of DNA damage by high concentrations of peroxide. The direct DNA oxidant both in vivo and in this in vitro system exhibits reactivity unlike that of a free hydroxyl radical and may instead be a ferryl radical.read more
Citations
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The effects of nitroxide radicals on oxidative DNA damage.
Elisabetta Damiani,Beata Kalinska,Adriana Canapa,Stefania Canestrari,Michal Wozniak,Ettore Olmo,Lucedio Greci +6 more
TL;DR: The results show that the majority of compounds tested protect both plasmid DNA and calf thymus DNA against AAPH-mediated oxidative damage in a concentration-dependent fashion, however, all compounds failed to protect DNA against damage inflicted by the presence of the transition metals in combination with H(2)O(2).
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Pulmonary responses of acute exposure to ultrafine iron particles in healthy adult rats
TL;DR: It is concluded that inhalation of iron particles leads to oxidative stress associated with a proinflammatory response in a dose‐dependent manner and the activation of NFκB may be involved in iron‐induced respiratory responses, but further studies are merited.
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Silver and hydrogen peroxide as potential drinking water disinfectants: their bactericidal effects and possible modes of action
TL;DR: It appears that the combined toxic effect of silver and HP may be related with damage to cellular proteins, and the involvement of other cellular moieties can not be ruled out.
Journal ArticleDOI
DNA damage and repair in age-related macular degeneration.
Jacek P. Szaflik,Katarzyna Janik-Papis,Ewelina Synowiec,Dominika Ksiazek,Magdalena Zaras,Katarzyna Wozniak,Jerzy Szaflik,Janusz Blasiak +7 more
TL;DR: It is postulate that the impaired efficacy of DNA repair may combine with enhanced sensitivity of RPE cells to blue and UV lights, contributing to the pathogenesis of AMD.
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Nanocomposites as biomolecules delivery agents in nanomedicine
TL;DR: The present review provides an overview of the most recent achievements related to different biomolecules used to enable targeting capabilities of highly diverse nanoparticles to obtain enhanced therapeutic efficacy, decrease the possibility of drug resistance, and reduce side effects of “conventional” therapy in cancers.
References
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Journal ArticleDOI
The biology of oxygen radicals
TL;DR: The reactive superoxide radical, O2-, formerly of concern only to radiation chemists and radiobiologists, is now understood to be a normal product of the biological reduction of molecular oxygen.
Journal ArticleDOI
The catalytic decomposition of hydrogen peroxide by iron salts
Fritz Haber,Joseph Weiss +1 more
TL;DR: Wansbrough-Jones as discussed by the authors gave the manuscript of this paper to Professor Sir William Pope, but the final revision for the press had not been made and in its original from the paper was not suitable for publication in an English journal; but since, Professor Haber had considered carefully how he wished to present the results embodied in it, the form and sequence of the paper remain unmodified.