Journal ArticleDOI
Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro.
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TLDR
An in vitro Fenton system was established that generates DNA strand breaks and inactivates bacteriophage and that also reproduces the suppression of DNA damage by high concentrations of peroxide.Abstract:
Exposure of Escherichia coli to low concentrations of hydrogen peroxide results in DNA damage that causes mutagenesis and kills the bacteria, whereas higher concentrations of peroxide reduce the amount of such damage. Earlier studies indicated that the direct DNA oxidant is a derivative of hydrogen peroxide whose formation is dependent on cell metabolism. The generation of this oxidant depends on the availability of both reducing equivalents and an iron species, which together mediate a Fenton reaction in which ferrous iron reduces hydrogen peroxide to a reactive radical. An in vitro Fenton system was established that generates DNA strand breaks and inactivates bacteriophage and that also reproduces the suppression of DNA damage by high concentrations of peroxide. The direct DNA oxidant both in vivo and in this in vitro system exhibits reactivity unlike that of a free hydroxyl radical and may instead be a ferryl radical.read more
Citations
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Mechanisms of the antioxidant effects of nitric oxide.
David A. Wink,Katrina M. Miranda,Michael Graham Espey,Ryzard M. Pluta,Sandra J. Hewett,Carol A. Colton,Michael P. Vitek,Martin Feelisch,Mathew B. Grisham +8 more
TL;DR: The attenuation of metal/peroxide oxidative chemistry, as well as lipid peroxidation, appears to be the major chemical mechanisms by which NO may limit oxidative injury to mammalian cells.
Journal ArticleDOI
Transcriptional Regulation by Ferric Uptake Regulator (Fur) in Pathogenic Bacteria
Bryan Troxell,Hosni M. Hassan +1 more
TL;DR: This review focuses on the breadth of Fur regulation in pathogenic bacteria since mutants of fur, perR, or zur exhibit reduced virulence within numerous animal and plant models of infection.
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Lipid peroxidation, free radical production and antioxidant status in breast cancer
Gibanananda Ray,Sanjay Batra,Nootan Kumar Shukla,Suryanarayan V.S. Deo,Vinod Raina,Seetharaman Ashok,Syed Akhtar Husain +6 more
TL;DR: Results of the study have shown a higher ROMs production and decreased CAT activity, which support the oxidative stress hypothesis in carcinogenesis and administration of CAT may be helpful in the management of BC patients.
Journal ArticleDOI
Regulation of growth and death in Escherichia coli by toxin–antitoxin systems
TL;DR: Escherichia coli K-12 contains at least 36 toxin genes, the expression of which causes growth inhibition and eventual death, usually co-expressed with their cognate antitoxins in operons called toxin–antitoxin (TA) modules.
Journal ArticleDOI
Near-Infrared Light-Initiated Molecular Superoxide Radical Generator: Rejuvenating Photodynamic Therapy against Hypoxic Tumors
Mingle Li,Jing Xia,Ruisong Tian,Jingyun Wang,Jiangli Fan,Jianjun Du,Saran Long,Xiangzhi Song,James W. Foley,Xiaojun Peng +9 more
TL;DR: A near-infrared (NIR) light-triggered molecular superoxide radical (O2-•) generator (ENBS-B) is developed to surmount this intractable issue and extend the options of excellent agents for clinical cancer therapy.
References
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Journal ArticleDOI
The biology of oxygen radicals
TL;DR: The reactive superoxide radical, O2-, formerly of concern only to radiation chemists and radiobiologists, is now understood to be a normal product of the biological reduction of molecular oxygen.
Journal ArticleDOI
The catalytic decomposition of hydrogen peroxide by iron salts
Fritz Haber,Joseph Weiss +1 more
TL;DR: Wansbrough-Jones as discussed by the authors gave the manuscript of this paper to Professor Sir William Pope, but the final revision for the press had not been made and in its original from the paper was not suitable for publication in an English journal; but since, Professor Haber had considered carefully how he wished to present the results embodied in it, the form and sequence of the paper remain unmodified.