Journal ArticleDOI
Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro.
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TLDR
An in vitro Fenton system was established that generates DNA strand breaks and inactivates bacteriophage and that also reproduces the suppression of DNA damage by high concentrations of peroxide.Abstract:
Exposure of Escherichia coli to low concentrations of hydrogen peroxide results in DNA damage that causes mutagenesis and kills the bacteria, whereas higher concentrations of peroxide reduce the amount of such damage. Earlier studies indicated that the direct DNA oxidant is a derivative of hydrogen peroxide whose formation is dependent on cell metabolism. The generation of this oxidant depends on the availability of both reducing equivalents and an iron species, which together mediate a Fenton reaction in which ferrous iron reduces hydrogen peroxide to a reactive radical. An in vitro Fenton system was established that generates DNA strand breaks and inactivates bacteriophage and that also reproduces the suppression of DNA damage by high concentrations of peroxide. The direct DNA oxidant both in vivo and in this in vitro system exhibits reactivity unlike that of a free hydroxyl radical and may instead be a ferryl radical.read more
Citations
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Live cell-specific fluorescent probe for the detection of labile Fe(II) and the evaluation of esterase activity in live animals
TL;DR: Imaging experiments showed that RAcy could be used as live cell-specific probe for the imaging of labile Fe(II) ion in live cells and animals, and also could be applied to the evaluation of esterase activity in live animals.
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Effect of iron supplementation on intestinal function and oxidative stress in piglets with induced colitis
TL;DR: In this paper, the effect of oral iron on the intestinal function and oxidative redox status in piglets with dextran sulphate sodium (DSS)-induced colitis was estimated.
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Impact of ageing on the fate of molybdate-zerovalent iron nanohybrid and its subsequent effect on cyanobacteria (Microcystis aeruginosa) growth in aqueous media.
Yiming Su,Yiming Su,Dongxv Qian,Adeyemi S. Adeleye,Jin Zhang,Xuefei Zhou,David Jassby,Yalei Zhang +7 more
TL;DR: It is shown that nZVI can immobilize Mo(VI) ions in groundwater, and the derived metal-nZVI hybrid can effectively suppress the potential growth of M. aeruginosa in river water.
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A Brief Review of the Controversial Role of Iron in Colorectal Carcinogenesis
TL;DR: The evidence for the controversial role of iron in pathogenesis of CRC is reviewed, illustrating the complex interplay of genetic and metabolic alterations in chemical carcinogenesis.
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Hydrogen peroxide sensing using Ce3+ luminescence of cerium oxide (CeO2-x) nanoparticles
TL;DR: In this paper, a nanoceria-based sensor for HP detection and quantification in water solutions is presented, which is based on the reversible shift of Ce3+↔Ce4+ balance in ceria nanoparticles as a result of nanocomposite-oxidant interaction.
References
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Journal ArticleDOI
The biology of oxygen radicals
TL;DR: The reactive superoxide radical, O2-, formerly of concern only to radiation chemists and radiobiologists, is now understood to be a normal product of the biological reduction of molecular oxygen.
Journal ArticleDOI
The catalytic decomposition of hydrogen peroxide by iron salts
Fritz Haber,Joseph Weiss +1 more
TL;DR: Wansbrough-Jones as discussed by the authors gave the manuscript of this paper to Professor Sir William Pope, but the final revision for the press had not been made and in its original from the paper was not suitable for publication in an English journal; but since, Professor Haber had considered carefully how he wished to present the results embodied in it, the form and sequence of the paper remain unmodified.