Journal ArticleDOI
What is a resistance gene? Ranking risk in resistomes.
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TLDR
Rules are proposed for estimating the risks associated with genes that are present in environmental resistomes by evaluating the likelihood of their introduction into human pathogens, and the consequences of such events for the treatment of infections.Abstract:
In this Opinion article, Baquero and colleagues propose a hierarchical system for estimating the risks associated with genes present in environmental resistomes, by evaluating the likelihood of their introduction into human pathogens, and the consequences of such introduction events for the treatment of bacterial infections.read more
Citations
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The microbiome of uncontacted Amerindians
Jose C. Clemente,Erica C. Pehrsson,Martin J. Blaser,Martin J. Blaser,Kuldip Sandhu,Zhan Gao,Bin Wang,Magda Magris,Glida Hidalgo,Monica Contreras,Oscar Noya-Alarcon,Orlana Lander,Jeremy McDonald,Michael J. Cox,Jens Walter,Phaik Lyn Oh,Jean F. Ruiz,Selena Rodriguez,Nan Shen,Se Jin Song,Jessica L. Metcalf,Rob Knight,Rob Knight,Gautam Dantas,M. Gloria Dominguez-Bello,M. Gloria Dominguez-Bello,M. Gloria Dominguez-Bello +26 more
TL;DR: It is suggested that westernization significantly affects human microbiome diversity and that functional AR genes appear to be a feature of the human microbiome even in the absence of exposure to commercial antibiotics.
Journal ArticleDOI
Environmental factors influencing the development and spread of antibiotic resistance
TL;DR: This work attempts to define the ecological and evolutionary environmental factors that contribute to resistance development and transmission and investigates under what conditions and to what extent environmental selection for resistance takes place.
Journal ArticleDOI
Human health risk assessment of antibiotic resistance associated with antibiotic residues in the environment: A review.
TL;DR: A holistic view of health risk assessment of antibiotic resistance associated with antibiotic residues in the environment in contrast with that of the antibiotic resistant bacteria is provided and the main knowledge gaps and the future research that should be prioritized to achieve the quantitative risk assessment are discussed.
Journal ArticleDOI
Antibiotic-Resistance Genes in Waste Water.
TL;DR: Some of the main methods for studying antibiotic resistance in waste waters and the latest research and main knowledge gaps on the issue are described and some future research directions are proposed.
Journal ArticleDOI
Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage
Rene S. Hendriksen,Patrick Munk,Patrick Murigu Kamau Njage,Bram A. D. van Bunnik,Luke McNally,Oksana Lukjancenko,Timo Röder,David F. Nieuwenhuijse,Susanne Karlsmose Pedersen,Jette Kjeldgaard,Rolf Sommer Kaas,Philip Thomas Lanken Conradsen Clausen,Josef Korbinian Vogt,Pimlapas Leekitcharoenphon,Milou G.M. van de Schans,T. Zuidema,Ana Maria de Roda Husman,Simon Rasmussen,Bent O. Petersen,Clara Amid,Guy Cochrane,Thomas Sicheritz-Pontén,Heike Schmitt,Jorge Raul Matheu Alvarez,Awa Aidara-Kane,Sünje Johanna Pamp,Ole Lund,Tine Hald,Mark E. J. Woolhouse,Marion Koopmans,Håkan Vigre,Thomas Nordahl Petersen,Frank Møller Aarestrup +32 more
TL;DR: It is suggested that global AMR gene diversity and abundance vary by region, and that improving sanitation and health could potentially limit the global burden of AMR.
References
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Journal ArticleDOI
Origins and Evolution of Antibiotic Resistance
Julian Davies,Dorothy Davies +1 more
TL;DR: A review of antibiotic resistance development over the past half-century can be found in this article, with the oft-restated conclusion that it is time to act and to restore the therapeutic applications of antibiotics.
Journal ArticleDOI
Identification of acquired antimicrobial resistance genes
Ea Zankari,Henrik Hasman,Salvatore Cosentino,Martin Vestergaard,Simon Rasmussen,Ole Lund,Frank Møller Aarestrup,Mette Voldby Larsen +7 more
TL;DR: A web server providing a convenient way of identifying acquired antimicrobial resistance genes in completely sequenced isolates was created, and the method was evaluated on WGS chromosomes and plasmids of 30 isolates.
Journal ArticleDOI
Antibiotic resistance—the need for global solutions
Ramanan Laxminarayan,Ramanan Laxminarayan,Ramanan Laxminarayan,Adriano Duse,Chand Wattal,Anita K. M. Zaidi,Heiman F. L. Wertheim,Nithima Sumpradit,Erika Vlieghe,Gabriel Levy Hara,Ian M. Gould,Herman Goossens,Christina Greko,Anthony D. So,Maryam Bigdeli,Goeran Tomson,Will Woodhouse,Eva Ombaka,Arturo Quizhpe Peralta,Farah Naz Qamar,Fatima Mir,Sam Kariuki,Zulfigar A. Bhutta,Anthony R.M. Coates,Richard Bergstrom,Gerard D. Wright,Eric D. Brown,Otto Cars +27 more
TL;DR: The global situation of antibiotic resistance, its major causes and consequences, and key areas in which action is urgently needed are described and identified.
Journal ArticleDOI
Characterization of a New Metallo-β-Lactamase Gene, blaNDM-1, and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India
Dongeun Yong,Mark Toleman,Christian G. Giske,Hyun Sun Cho,Kristina Sundman,Kyungwon Lee,Timothy R. Walsh +6 more
TL;DR: A Swedish patient of Indian origin traveled to New Delhi, India, and acquired a urinary tract infection caused by a carbapenem-resistant Klebsiella pneumoniae strain that typed to the sequence type 14 complex, showing broad resistance carried on these plasmids.
Journal ArticleDOI
Natural Antibiotic Resistance and Contamination by Antibiotic Resistance Determinants: The Two Ages in the Evolution of Resistance to Antimicrobials
TL;DR: The study of antibiotic resistance has been historically concentrated on the analysis of bacterial pathogens and on the consequences of acquiring resistance for human health, but the studies on antibiotic resistance should not be confined to clinical-associated ecosystems.
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