A
Alexandra Zhernakova
Researcher at University Medical Center Groningen
Publications - 242
Citations - 36684
Alexandra Zhernakova is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Microbiome & Population. The author has an hindex of 71, co-authored 209 publications receiving 26730 citations. Previous affiliations of Alexandra Zhernakova include Northwestern University & Boston Children's Hospital.
Papers
More filters
Journal ArticleDOI
Genetics of rheumatoid arthritis contributes to biology and drug discovery
Yukinori Okada,Yukinori Okada,Di Wu,Di Wu,Di Wu,Gosia Trynka,Gosia Trynka,Towfique Raj,Towfique Raj,Chikashi Terao,Katsunori Ikari,Yuta Kochi,Koichiro Ohmura,Akari Suzuki,Shinji Yoshida,Robert R. Graham,A. Manoharan,Ward Ortmann,Tushar Bhangale,Joshua C. Denny,Robert J. Carroll,Anne E. Eyler,Jeff Greenberg,Joel M. Kremer,Dimitrios A. Pappas,Lei Jiang,Jian Yin,Lingying Ye,Ding Feng Su,Jian Yang,Gang Xie,E.C. Keystone,Harm-Jan Westra,Tõnu Esko,Tõnu Esko,Tõnu Esko,Andres Metspalu,Xuezhong Zhou,Namrata Gupta,Daniel B. Mirel,Eli A. Stahl,Dorothee Diogo,Dorothee Diogo,Jing Cui,Jing Cui,Katherine P. Liao,Katherine P. Liao,Michael H. Guo,Michael H. Guo,Keiko Myouzen,Takahisa Kawaguchi,Marieke J H Coenen,Piet L. C. M. van Riel,Mart A F J van de Laar,Henk-Jan Guchelaar,Tom W J Huizinga,Philippe Dieudé,Xavier Mariette,S. Louis Bridges,Alexandra Zhernakova,Alexandra Zhernakova,René E. M. Toes,Paul P. Tak,Paul P. Tak,Paul P. Tak,Corinne Miceli-Richard,So Young Bang,Hye Soon Lee,Javier Martin,Miguel A. Gonzalez-Gay,Luis Rodriguez-Rodriguez,Solbritt Rantapää-Dahlqvist,Lisbeth Ärlestig,Hyon K. Choi,Hyon K. Choi,Yoichiro Kamatani,Pilar Galan,Mark Lathrop,Steve Eyre,Steve Eyre,John Bowes,John Bowes,Anne Barton,Niek de Vries,Larry W. Moreland,Lindsey A. Criswell,Elizabeth W. Karlson,Atsuo Taniguchi,Ryo Yamada,Michiaki Kubo,Jun Liu,Sang Cheol Bae,Jane Worthington,Jane Worthington,Leonid Padyukov,Lars Klareskog,Peter K. Gregersen,Soumya Raychaudhuri,Soumya Raychaudhuri,Barbara E. Stranger,Philip L. De Jager,Philip L. De Jager,Lude Franke,Peter M. Visscher,Matthew A. Brown,Hisashi Yamanaka,Tsuneyo Mimori,Atsushi Takahashi,Huji Xu,Timothy W. Behrens,Katherine A. Siminovitch,Shigeki Momohara,Fumihiko Matsuda,Kazuhiko Yamamoto,Robert M. Plenge,Robert M. Plenge +115 more
TL;DR: A genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries provides empirical evidence that the genetics of RA can provide important information for drug discovery, and sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis.
Journal ArticleDOI
Environment dominates over host genetics in shaping human gut microbiota
Daphna Rothschild,Omer Weissbrod,Elad Barkan,Alexander Kurilshikov,Tal Korem,David Zeevi,Paul I. Costea,Anastasia Godneva,Iris N. Kalka,Noam Bar,Smadar Shilo,Dar Lador,Arnau Vich Vila,Niv Zmora,Niv Zmora,Meirav Pevsner-Fischer,David Israeli,Noa Kosower,Gal Malka,Bat Chen Wolf,Tali Avnit-Sagi,Maya Lotan-Pompan,Adina Weinberger,Zamir Halpern,Shai Carmi,Jingyuan Fu,Cisca Wijmenga,Cisca Wijmenga,Alexandra Zhernakova,Eran Elinav,Eran Segal +30 more
TL;DR: Genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment are examined, and it is demonstrated that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition.
Journal ArticleDOI
Systematic identification of trans eQTLs as putative drivers of known disease associations
Harm-Jan Westra,Marjolein J. Peters,Tõnu Esko,Hanieh Yaghootkar,Claudia Schurmann,Johannes Kettunen,Mark W. Christiansen,Benjamin P. Fairfax,Katharina Schramm,Joseph E. Powell,Alexandra Zhernakova,Daria V. Zhernakova,Jan H. Veldink,Leonard H. van den Berg,Juha Karjalainen,Sebo Withoff,André G. Uitterlinden,Albert Hofman,Fernando Rivadeneira,Peter A C 't Hoen,Eva Reinmaa,Krista Fischer,Mari Nelis,Lili Milani,David Melzer,Luigi Ferrucci,Andrew B. Singleton,Dena G. Hernandez,Mike A. Nalls,Georg Homuth,Matthias Nauck,Dörte Radke,Uwe Völker,Markus Perola,Veikko Salomaa,Jennifer A. Brody,Astrid Suchy-Dicey,Sina A. Gharib,Daniel A. Enquobahrie,Thomas Lumley,Grant W. Montgomery,Seiko Makino,Holger Prokisch,Christian Herder,Michael Roden,Harald Grallert,Thomas Meitinger,Konstantin Strauch,Yang Li,Ritsert C. Jansen,Peter M. Visscher,Julian C. Knight,Bruce M. Psaty,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Alexander Teumer,Timothy M. Frayling,Andres Metspalu,Joyce B. J. van Meurs,Lude Franke +60 more
TL;DR: Variants associated with cholesterol metabolism and type 1 diabetes showed similar phenomena, indicating that large-scale eQTL mapping provides insight into the downstream effects of many trait-associated variants.
Journal ArticleDOI
Population-level analysis of gut microbiome variation
Gwen Falony,Marie Joossens,Marie Joossens,Sara Vieira-Silva,Jun Wang,Youssef Darzi,Youssef Darzi,Karoline Faust,Karoline Faust,Alexander Kurilshikov,Marc Jan Bonder,Mireia Valles-Colomer,Doris Vandeputte,Doris Vandeputte,Raul Y. Tito,Raul Y. Tito,Samuel Chaffron,Samuel Chaffron,Leen Rymenans,Leen Rymenans,Chloë Verspecht,Lise De Sutter,Lise De Sutter,Gipsi Lima-Mendez,Kevin D'hoe,Kevin D'hoe,Karl Jonckheere,Karl Jonckheere,Daniel Homola,Daniel Homola,Roberto Garcia,Roberto Garcia,Ettje F. Tigchelaar,Linda Eeckhaudt,Linda Eeckhaudt,Jingyuan Fu,Liesbet Henckaerts,Alexandra Zhernakova,Cisca Wijmenga,Jeroen Raes,Jeroen Raes +40 more
TL;DR: Stool consistency showed the largest effect size, whereas medication explained largest total variance and interacted with other covariate-microbiota associations, and proposed disease marker genera associated to host covariates were found associated to microbiota compositional variation with a 92% replication rate.
Journal ArticleDOI
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
Eli A. Stahl,Soumya Raychaudhuri,Soumya Raychaudhuri,Elaine F. Remmers,Gang Xie,Stephen Eyre,Brian Thomson,Yonghong Li,Fina A S Kurreeman,Fina A S Kurreeman,Fina A S Kurreeman,Alexandra Zhernakova,Anne Hinks,Candace Guiducci,Robert Chen,Lars Alfredsson,Christopher I. Amos,Kristin G. Ardlie,Anne Barton,John Bowes,Elisabeth Brouwer,Noël P. Burtt,Joseph J. Catanese,Jonathan S. Coblyn,Marieke J H Coenen,Karen H. Costenbader,Lindsey A. Criswell,J. Bart A. Crusius,Jing Cui,Paul I.W. de Bakker,Paul I.W. de Bakker,Philip L. De Jager,Philip L. De Jager,Bo Ding,Paul Emery,Edward Flynn,Pille Harrison,Lynne J. Hocking,Tom W J Huizinga,Daniel L. Kastner,Xiayi Ke,Annette Lee,Xiangdong Liu,Paul Martin,Ann W. Morgan,Leonid Padyukov,Marcel D. Posthumus,Timothy R D J Radstake,David M. Reid,Mark Seielstad,Michael F. Seldin,Nancy A. Shadick,Sophia Steer,Paul P. Tak,Wendy Thomson,Annette H M van der Helm-van Mil,Irene E. van der Horst-Bruinsma,C. Ellen van der Schoot,Piet L. C. M. van Riel,Michael E. Weinblatt,Anthony G. Wilson,Gertjan Wolbink,B. Paul Wordsworth,Cisca Wijmenga,Elizabeth W. Karlson,René E. M. Toes,Niek de Vries,Ann B. Begovich,Ann B. Begovich,Jane Worthington,Katherine A. Siminovitch,Peter K. Gregersen,Lars Klareskog,Robert M. Plenge,Robert M. Plenge +74 more
TL;DR: Seven new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 × 10−8) in an analysis of all 41,282 samples, and an additional 11 SNPs replicated at P < 0.05, suggesting that most represent genuine rhearatoid arthritisrisk alleles.