A
Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
Papers
More filters
Journal ArticleDOI
Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain
Aaron M. Teitelbaum,Sharon E. Murphy,Gustav Akk,Timothy B. Baker,Allison L. Germann,L B von Weymarn,Laura J. Bierut,Alison Goate,Evan D. Kharasch,A J Bloom +9 more
TL;DR: Nicotine N-oxidation in human brain is demonstrated for the first time, mediated by FMO3 and FMO1, and nicotine-N-oxide modulates human α4β2 nicotinic receptor activity in vitro.
Journal ArticleDOI
Greater effect of polygenic risk score for Alzheimer's disease among younger cases who are apolipoprotein E-ε4 carriers
Brian Fulton-Howard,Alison Goate,Robert P. Adelson,Jeremy Koppel,Marc L. Gordon,Nir Barzilai,Gil Atzmon,Peter Davies,Yun Freudenberg-Hua,Yun Freudenberg-Hua +9 more
TL;DR: It is found that PRSnon-APOE modifies age at onset among APOE4 carriers, but not among noncarriers, and the known AD risk variants are particularly detrimental in young APoe4 carriers.
Journal ArticleDOI
Phenotypic Similarities Between Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease: A Single-Family Case-Control Study
Gregory S. Day,Erik S. Musiek,Catherine M. Roe,Joanne Norton,Alison Goate,Carlos Cruchaga,Nigel J. Cairns,John C. Morris +7 more
TL;DR: To use a family with late-onset ADAD caused by a presenilin 1 (PSEN1) gene mutation to mitigate the potential confound of age when comparing ADAD and LOAD, the amyloidogenic PSEN1 A79V mutation recapitulates the clinical attributes of LOAD.
Journal ArticleDOI
A genome-wide association study of interhemispheric theta EEG coherence: implications for neural connectivity and alcohol use behavior.
Jacquelyn L. Meyers,Jian Zhang,David B. Chorlian,Ashwini K. Pandey,Chella Kamarajan,Jen Chyong Wang,Leah Wetherill,Dongbing Lai,Michael Chao,Grace Chan,Sivan Kinreich,Manav Kapoor,Sarah Bertelsen,Jeanette N. McClintick,Lance O. Bauer,Victor Hesselbrock,Samuel Kuperman,John Kramer,Jessica E. Salvatore,Danielle M. Dick,Arpana Agrawal,Tatiana Foroud,Howard J. Edenberg,Alison Goate,Bernice Porjesz +24 more
TL;DR: Converging data provide support for the role of genetic variants on chromosome 18q23 in regulating neural connectivity and alcohol use behavior, potentially via dysregulated myelination.
Journal ArticleDOI
A physical map of the human APP gene in YACs
TL;DR: To determine the size of the APP gene and the organization of the exons within human genomic DNA, 11 Yeast Artificial Chromosome (YAC), recombinants containing human APP gene sequences are characterized.