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Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
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Journal ArticleDOI
Are early atrophy patterns in autosomal dominant familial Alzheimer's disease gene-dependent?
Kirsi M. Kinnunen,Natalie S. Ryan,David M. Cash,António Bastos Leite,Sarah Finnegan,Manuel Jorge Cardoso,Kelvin K. Leung,Marc Modat,Tammie L.S. Benzinger,Clifford R. Jack,Daniel S. Marcus,Marcus E. Raichle,Paul M. Thompson,John M. Ringman,Bernardino Ghetti,Stephen Salloway,Reisa A. Sperling,Peter R. Schofield,Colin L. Masters,Richard Mayeux,Ralph N. Martins,Michael W. Weiner,Randall J. Bateman,Alison Goate,Anne M. Fagan,Nigel J. Cairns,Virginia Buckles,John C. Morris,Martin N. Rossor,Sebastien Ourselin,Nick C. Fox +30 more
Journal ArticleDOI
CSF Biomarkers in Down Syndrome and Autosomal Dominant Alzheimer Disease
Anne M. Fagan,Rachel L. Henson,Yan Li,Anna H. Boerwinkle,Chengjie Xiong,Randall J. Bateman,Alison Goate,Beau M. Ances,Eric Doran,Bradley T. Christian,Florence Lai,H. Diana Rosas,Nicole Schupf,Wayne Silverman,Joseph H. Lee,William E. Klunk,Benjamin L. Handen,Ricardo F. Allegri,Jasmeer P. Chhatwal,Gregory S. Day,Neill R. Graff-Radford,Mathias Jucker,Mathias Jucker,Johannes Levin,Johannes Levin,Ralph N. Martins,Colin L. Masters,Hiroshi Mori,Catherine J. Mummery,Yoshiki Niimi,John M. Ringman,Stephen Salloway,Peter R. Schofield,Mikio Soji,Ira T. Lott +34 more
TL;DR: CSF biomarker profiles are useful for identifying and tracking AD-related processes in DS and will likely have utility for clinical care and clinical trial design in this understudied at-risk population.
Journal ArticleDOI
Discovery and validation of dominantly inherited Alzheimer’s disease mutations in populations from Latin America
Leonel T. Takada,Carmen Alaez-Verson,Bhagyashri D. Burgute,Ricardo Nitrini,Ana Luisa Sosa,Raphael Machado de Castilhos,Marcia Lorena Fagundes Chaves,E. Mariana Longoria,Karol Carrillo-Sánchez,S. Brucki,Luis Leonardo Flores-Lagunes,Carolina Molina,Marco Jiménez Olivares,Ellen Ziegemeier,Jennifer Petranek,Alison Goate,C. Cruchaga,Alan E. Renton,Maria Victoria Fernandez,Gregory S. Day,Eric McDade,Randall J. Bateman,Celeste M. Karch,Jorge J. Llibre-Guerra,for the Alberta Kidney Disease Network +24 more
TL;DR: In this article , the authors used a systematic approach to assign the likelihood of pathogenicity in variants from densely affected families in Latin American populations, and identified five novel variants in the presenilin1 (PSEN1) gene from Brazilian and Mexican families.
Journal ArticleDOI
Cerebrospinal fluid levels of amyloid beta and tau as endophenotypes reveal novel variants potentially informative for alzheimer's disease
Yuetiva Deming,Oscar Harari,Kathleen Black,David Carrell,Yefei Cai,Jorge L. Del-Aguila,Victoria Fernandez,John P. Budde,Shengmei Ma,Ben Saef,Sarah Bertelsen,John S. K. Kauwe,Anne M. Fagan,David M. Holtzman,John C. Morris,Sungeun Kim,Andrew J. Saykin,Philip L. De Jager,Alison Goate,Carlos Cruchaga,Marilyn S. Albert,Abhay Moghekar,Richard O'Brien,Matthias Riemenschneider,Ronald C. Petersen,Kaj Blennow,Henrik Zetterberg,Lennart Minthon,Vivianna M. Van Deerlin,Virginia M.-Y. Lee,Leslie M. Shaw,John Q. Trojanowski,Elaine R. Peskind,Gail Li +33 more
Posted ContentDOI
Multi-omics integration analysis identifies novel genes for alcoholism with potential link to neurodegenerative diseases
Manav Kapoor,Michael Chao,Emma C. Johnson,Gloriia Novikova,Dongbing Lai,Jacquelyn L. Meyers,Jessica Schulman,John I. Nurnberger,Bernice Porjesz,Yunlong Liu,Howard J. Edenberg,Edoardo Marcora,Arpana Agrawal,Alison Goate +13 more
TL;DR: Integrating GWAS summary statistics with multi-omics datasets from multiple sources identified biological similarities and differences between typical alcohol intake and disordered drinking highlighting molecular heterogeneity that might inform future targeted functional and cross-species studies.