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Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
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A genome-wide screen for genes influencing conduct disorder
Danielle M. Dick,Ting-Kai Li,Ting-Kai Li,Howard J. Edenberg,Victor Hesselbrock,John J. Kramer,Samuel Kuperman,Bernice Porjesz,K. K. Bucholz,Alison Goate,John I. Nurnberger,Tatiana Foroud +11 more
TL;DR: The results suggest that regions on chromosomes 19 and 2 may contain genes conferring risk to conduct disorder and some of the genes contributing to alcohol dependence in adulthood may also contribute to conduct Disorder in childhood.
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Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium
Renato Polimanti,Raymond K. Walters,Emma C. Johnson,Jeanette N. McClintick,Amy E. Adkins,Daniel E. Adkins,Silviu-Alin Bacanu,Laura J. Bierut,Tim B. Bigdeli,Sandra A. Brown,Kathleen K. Bucholz,William E. Copeland,E. Jane Costello,Louisa Degenhardt,Lindsay A. Farrer,Tatiana Foroud,Louis Fox,Alison Goate,Richard A. Grucza,Laura M. Hack,Dana B. Hancock,Sarah M. Hartz,Andrew C. Heath,John K. Hewitt,Christian J. Hopfer,Eric O. Johnson,Kenneth S. Kendler,Henry R. Kranzler,Kenneth Krauter,Dongbing Lai,Pamela A. F. Madden,Nicholas G. Martin,Hermine H. Maes,Elliot C. Nelson,Roseann E. Peterson,Bernice Porjesz,Brien P. Riley,Nancy L. Saccone,Michael C. Stallings,Tamara L. Wall,Bradley T. Webb,Leah Wetherill,Howard J. Edenberg,Arpana Agrawal,Joel Gelernter +44 more
TL;DR: A genome-wide analysis comparing 4503 OD cases, 4173 opioid-exposed controls, and 32,500 opioid-unexp exposed controls, including participants of European and African descent found variants associated with OE, which highlights the difference between dependence and exposure and the importance of considering the definition of controls in studies of addiction.
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Peroxisome Proliferator-Activated Receptors α and γ are Linked with Alcohol Consumption in Mice and Withdrawal and Dependence in Humans
Yuri A. Blednov,Jillian M. Benavidez,Mendy Black,Laura B. Ferguson,Grant L. Schoenhard,Alison Goate,Howard J. Edenberg,Leah Wetherill,Victor Hesselbrock,Tatiana Foroud,R. Adron Harris +10 more
TL;DR: Reduced EtOH intake in mice and the genetic association between AD or withdrawal in humans highlight the potential for repurposing FDA-approved PPARα or PPARγ agonists for the treatment of AD.
Journal ArticleDOI
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia
Julia Tcw,Lu Qian,Nina H. Pipalia,Michael J. Chao,Shuang Liang,Yang Shi,Bharat R. Jain,Sarah Bertelsen,Manav Kapoor,Edoardo Marcora,Elizabeth Sikora,Elizabeth J. Andrews,Alessandra C. Martini,Celeste M. Karch,Elizabeth Head,David M. Holtzman,Bin Zhang,Minghui Wang,Frederick R. Maxfield,Wayne W. Poon,Alison Goate +20 more
TL;DR: In this paper , the effects of APOE4 on brain cell types derived from population and isogenic human induced pluripotent stem cells, post-mortem brain, and APOE targeted replacement mice were investigated.
Journal ArticleDOI
Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.
Allan M. Andersen,Robert H. Pietrzak,Robert H. Pietrzak,Henry R. Kranzler,Henry R. Kranzler,Li Ma,Hang Zhou,Xiaoming Liu,John Kramer,Samuel Kuperman,Howard J. Edenberg,John I. Nurnberger,John P. Rice,Jay A. Tischfield,Alison Goate,Tatiana Foroud,Jacquelyn L. Meyers,Bernice Porjesz,Danielle M. Dick,Victor Hesselbrock,Eric Boerwinkle,Steven M. Southwick,Steven M. Southwick,John H. Krystal,John H. Krystal,Myrna M. Weissman,Myrna M. Weissman,Douglas F. Levinson,James B. Potash,James B. Potash,James B. Potash,Joel Gelernter,Joel Gelernter,Shizhong Han,Shizhong Han +34 more
TL;DR: In this paper, the authors examined whether major depressive disorder (MDD) and alcohol dependence (AD) overlap genetically, using a polygenic score approach and found that higher MDD PRS was associated with a significantly increased risk of AD in all samples.