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Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
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SUCLG2 identified as both a determinator of CSF Aβ1–42 levels and an attenuator of cognitive decline in Alzheimer's disease
Alfredo Ramirez,Wiesje M. van der Flier,Christine Herold,David Ramonet,Stefanie Heilmann,Piotr Lewczuk,Julius Popp,André Lacour,Dmitriy Drichel,Eva Louwersheimer,Markus P. Kummer,Carlos Cruchaga,Per Hoffmann,Charlotte E. Teunissen,Henne Holstege,Johannes Kornhuber,Oliver Peters,Adam C. Naj,Vincent Chouraki,Céline Bellenguez,Céline Bellenguez,Céline Bellenguez,Amy Gerrish,Alzheimer's Disease Neuroimaging Initiative,R. Heun,Lutz Frölich,Michael Hüll,Lara Buscemi,Stefan Herms,Heike Kölsch,Philip Scheltens,Monique M.B. Breteler,Eckart Rüther,Jens Wiltfang,Alison Goate,Frank Jessen,Wolfgang Maier,Michael T. Heneka,Tim Becker,Tim Becker,Markus M. Nöthen +40 more
TL;DR: Functional microglia experiments showed that SUCLG2 was involved in clearance of Aβ1-42 and Clinically, rs62256378 was associated with rate of cognitive decline in AD dementia patients and an interaction between APOE genotype and rs62 256378 was detected.
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Predicting sporadic Alzheimer's disease progression via inherited Alzheimer's disease-informed machine-learning.
Nicolai Franzmeier,Nikolaos Koutsouleris,Tammie L.S. Benzinger,Alison Goate,Celeste M. Karch,Anne M. Fagan,Eric McDade,Marco Duering,Martin Dichgans,Martin Dichgans,Johannes Levin,Johannes Levin,Brian A. Gordon,Yen Ying Lim,Colin L. Masters,Martin N. Rossor,Nick C. Fox,Antoinette O'Connor,Jasmeer P. Chhatwal,Stephen Salloway,Adrian Danek,Jason Hassenstab,Peter R. Schofield,Peter R. Schofield,John C. Morris,Randall J. Bateman,Michael Ewers +26 more
TL;DR: This work presents a new cross‐validated multi‐biomarker models for the prediction of the rate of cognitive decline in Alzheimer's disease and shows clear trends in prognosis and disease progression.
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Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS)
Hui Shi,Olivia Belbin,Christopher Medway,Kristelle Brown,Noor Kalsheker,Minerva M. Carrasquillo,Petroula Proitsi,John Powell,Simon Lovestone,Alison Goate,Steven G. Younkin,Peter Passmore,Kevin Morgan +12 more
TL;DR: In this article, the 10 most promising late-onset Alzheimer's disease (LOAD) susceptibility genes identified through several recent large genome-wide association studies (GWAS) were selected.
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Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence
Gabe Haller,Manav Kapoor,John P. Budde,Xiaoling Xuei,Howard J. Edenberg,John I. Nurnberger,John Kramer,Andrew Brooks,Jay A. Tischfield,Laura Almasy,Arpana Agrawal,Kathleen K. Bucholz,John P. Rice,Nancy L. Saccone,Laura J. Bierut,Alison Goate +15 more
TL;DR: These are the first results to implicate rare variants in CHRNB3 or CHRNA3 in risk for alcohol dependence or cocaine dependence.
Journal ArticleDOI
Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease
Yonghong Li,Andrew Grupe,Charles M. Rowland,Peter Holmans,Ricardo Segurado,Richard Abraham,Lesley Jones,Joseph J. Catanese,David Ross,Kevin Mayo,Maribel Martinez,Paul Hollingworth,Alison Goate,Nigel J. Cairns,Brad A. Racette,Joel S. Perlmutter,Michael Conlon O'Donovan,John C. Morris,Carol Brayne,David C. Rubinsztein,Simon Lovestone,Leon J. Thal,Michael John Owen,Julie Williams +23 more
TL;DR: A large scale, multi-tiered association study testing 4692 single nucleotide polymorphism (SNPs) identified a SNP within a putative transcription factor binding site in the NEDD9 gene (neural precursor cell expressed, developmentally down-regulated), that shows good evidence of association with disease risk in four out of five LOAD samples, implicate NEDd9 as a novel susceptibility gene for LOAD and possibly PD.