A
Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
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Journal ArticleDOI
A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.
Celeste M. Karch,Aimee W. Kao,Anna Karydas,Khadijah Onanuga,Rita Martinez,Andrea R. Argouarch,Chao Wang,Cindy Shen Huang,Peter Dongmin Sohn,Kathryn R. Bowles,Salvatore Spina,M. Catarina Silva,Jacob A. Marsh,Simon Hsu,Derian A. Pugh,Nupur Ghoshal,Joanne Norton,Yadong Huang,Suzee E. Lee,William W. Seeley,Panagiotis Theofilas,Lea T. Grinberg,Fermin Moreno,Kathryn McIlroy,Bradley F. Boeve,Nigel J. Cairns,John F. Crary,Stephen J. Haggarty,Justin K. Ichida,Kenneth S. Kosik,Bruce L. Miller,Li Gan,Alison Goate,Sally Temple,Carolina Alquezar,Kathryn Bowles,David Butler,Israel Hernandez,Valerie Hennes,Martin Kampmann +39 more
TL;DR: A resource of fibroblasts, iPSCs, and NPCs with comprehensive clinical histories that can be accessed by the scientific community for disease modeling and development of novel therapeutics for tauopathies is presented.
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Haplotype-based association analysis of the MAPT locus in Late Onset Alzheimer's disease
TL;DR: The data suggest that the tagged SNPs forming the H1c haplotype do not have a causal role in the pathogenesis of LOAD, and the set of SNPs in general or rs242557 in particular are pathogenic for LOAD.
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CHRM2, Parental Monitoring, and Adolescent Externalizing Behavior Evidence for Gene-Environment Interaction
Danielle M. Dick,Jacquelyn L. Meyers,Shawn J. Latendresse,Hanneke E. Creemers,Hanneke E. Creemers,Jennifer E. Lansford,Gregory S. Pettit,John E. Bates,Kenneth A. Dodge,John P. Budde,Alison Goate,Jan K. Buitelaar,J. Ormel,Frank C. Verhulst,Anja C. Huizink,Anja C. Huizink +15 more
TL;DR: This work tested for association between CHRM2 and prospectively measured externalizing behavior in a longitudinal, community-based sample of adolescents, as well as for moderation of this association by parental monitoring, and found evidence for an interaction in which the association between the genotype and Externalizing behavior was stronger in environments with lower parental monitoring.
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The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease.
Nicolai Franzmeier,Jinyi Ren,Alexander Damm,Gemma Monté-Rubio,Mercè Boada,Agustín Ruiz,Alfredo Ramirez,Alfredo Ramirez,Frank Jessen,Frank Jessen,Emrah Düzel,Octavio Rodríguez Gómez,Tammie L.S. Benzinger,Alison Goate,Celeste M. Karch,Anne M. Fagan,Eric McDade,Katharina Buerger,Katharina Buerger,Johannes Levin,Johannes Levin,Marco Duering,Martin Dichgans,Martin Dichgans,Marc Suárez-Calvet,Marc Suárez-Calvet,Marc Suárez-Calvet,Christian Haass,Christian Haass,Brian A. Gordon,Yen Ying Lim,Colin L. Masters,Daniel Janowitz,Cihan Catak,Steffen Wolfsgruber,Steffen Wolfsgruber,Michael Wagner,Michael Wagner,Esther Milz,Sonia Moreno-Grau,Stefan J. Teipel,Michel J. Grothe,Ingo Kilimann,Martin N. Rossor,Nick C. Fox,Christoph Laske,Christoph Laske,Jasmeer P. Chhatwal,Peter Falkai,Robert Perneczky,Jae-Hong Lee,Annika Spottke,Annika Spottke,Henning Boecker,Henning Boecker,Frederic Brosseron,Frederic Brosseron,Klaus Fliessbach,Klaus Fliessbach,Michael T. Heneka,Michael T. Heneka,Peter J. Nestor,Peter J. Nestor,Oliver Peters,Oliver Peters,Manuel Fuentes,Manuel Fuentes,Felix Menne,Felix Menne,Josef Priller,Josef Priller,Eike Jakob Spruth,Eike Jakob Spruth,Christiana Franke,Christiana Franke,Anja Schneider,Anja Schneider,Christine Westerteicher,Christine Westerteicher,Oliver Speck,Jens Wiltfang,Jens Wiltfang,Jens Wiltfang,Claudia Bartels,Miguel Ángel Araque Caballero,Miguel Ángel Araque Caballero,Coraline D. Metzger,Daniel Bittner,Stephen Salloway,Adrian Danek,Jason Hassenstab,Igor Yakushev,Peter R. Schofield,Peter R. Schofield,John C. Morris,Randall J. Bateman,Michael Ewers +96 more
TL;DR: It is suggested that BDNF Val66Met is selectively associated with a higher vulnerability of hippocampus-frontal connectivity to primary AD pathology, resulting in greater AD-related cognitive impairment.
Journal ArticleDOI
Conserved “PAL” sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes
TL;DR: The P433L holoprotein is stable and incorporated into the high molecular weight gamma-secretase complex, arguing that P433 is not necessary for formation or stabilization of the gamma- secretase complex.