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Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
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Journal ArticleDOI
Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease
Hsiang Han Chen,Abdallah M. Eteleeb,Ciyang Wang,Maria Victoria Fernandez,John P. Budde,Kristy Bergmann,Joanne Norton,Fengxiang Wang,Curtis Ebl,John C. Morris,R. Perrino,Randall J. Bateman,Eric McDade,Chengjie Xiong,Alison Goate,Martin R. Farlow,Jasmeer P. Chhatwal,Peter R. Schofield,Helena C. Chui,Oscar Harari,Carlos Cruchaga,Laura Ibanez +21 more
TL;DR: In this article , the authors investigated differences in brain gene expression of linear and circular transcripts from the three ADAD genes in controls, sporadic AD, and ADAD, and found significant differences in gene counts of circ PSEN1 in ADAD individuals, when compared to sporadic AD and controls.
Journal ArticleDOI
Phenotypic similarities between late-onset autosomal dominant and sporadic alzheimer disease: a single-family case-control study
Gregory S. Day,Erik S. Musiek,Catherine M. Roe,Joanne Norton,Alison Goate,Carlos Cruchaga,Nigel J. Cairns,John C. Morris +7 more
TL;DR: In this paper, a case-control study was conducted at the Knight Alzheimer Disease Research Center at Washington University, St Louis, Missouri, and other National Institutes of Aging-funded AD centers in the United States.
Journal ArticleDOI
Correction: GWAS on family history of Alzheimer's disease.
Riccardo E. Marioni,Sarah E. Harris,Qian Zhang,Allan F. McRae,Saskia P. Hagenaars,Saskia P. Hagenaars,W. David Hill,Gail Davies,Craig W. Ritchie,Catharine R. Gale,Catharine R. Gale,John M. Starr,Alison Goate,David J. Porteous,Jian Yang,Kathryn L. Evans,Ian J. Deary,Naomi R. Wray,Peter M. Visscher,Peter M. Visscher +19 more
TL;DR: An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Posted ContentDOI
A common haplotype lowers SPI1 (PU.1) expression in myeloid cells and delays age at onset for Alzheimer's disease
Kuan-lin Huang,Edoardo Marcora,Anna A. Pimenova,Antonio Fabio Di Narzo,Manav Kapoor,Sheng Chih Jin,Oscar Harari,Sarah Bertelsen,Benjamin P. Fairfax,Jake Czajkowski,Vincent Chouraki,Benjamin Grenier-Boley,Céline Bellenguez,Yuetiva Deming,Andrew M. McKenzie,Towfique Raj,Alan E. Renton,John P. Budde,Albert V. Smith,Annette L. Fitzpatrick,Joshua C. Bis,Anita L. DeStefano,Hieab H.H. Adams,M. Arfan Ikram,Sven J. van der Lee,Jorge L. Del-Aguila,Maria Victoria Fernandez,Laura Ibanez,Rebecca Sims,Valentina Escott-Price,Richard Mayeux,Jonathan L. Haines,Lindsay A. Farrer,Margaret A. Pericak-Vance,Jean-Charles Lambert,Cornelia M. van Duijn,Lenore J. Launer,Sudha Seshadri,Julie Williams,Philippe Amouyel,Gerard D. Schellenberg,Bin Zhang,Ingrid B. Borecki,John S. K. Kauwe,Carlos Cruchaga,Ke Hao,Alison Goate +46 more
TL;DR: It is suggested that lower SPI1 expression reduces AD risk by modulating myeloid cell gene expression and function.
Posted ContentDOI
Allele-Specific Expression and High-Throughput Reporter Assay Reveal Functional Variants in Human Brains with Alcohol Use Disorders
Xi Rao,Kriti S. Thapa,Andy B. Chen,Hai Lin,Hongyu Gao,Jill L. Reiter,Katherine A. Hargreaves,Joseph Ipe,Dongbing Lai,Xiaoling Xuei,Hongmei Gu,Manav Kapoor,Sean P. Farris,Jay A. Tischfield,Tatiana Foroud,Alison Goate,Todd C. Skaar,Mayfield Rd,Howard J. Edenberg,Yunlong Liu +19 more
TL;DR: To test which variants associated with alcohol use disorder (AUDs) may cause expression differences, deep RNA-seq and genome-wide association studies (GWAS) data from four postmortem brain regions were integrated and 90 genes with differential ASE in subjects with AUDs compared to controls were identified.