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Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
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Genetic variability at the amyloid-beta precursor protein locus may contribute to the risk of late-onset Alzheimer's disease.
F. Wavrant-De Vrieze,Richard Crook,Peter Holmans,Peter Holmans,Patrick G. Kehoe,Michael John Owen,Julie Williams,Kimberly A. Roehl,D. K. Laliiri,Shantia Shears,Jeremy Booth,William Wu,Alison Goate,Marie-Christine Chartier-Harlin,John Hardy,Jordi Pérez-Tur +15 more
TL;DR: Analysis of sibpairs with late onset Alzheimer's disease suggests that neither the PS1 nor the PS2 gene is a major locus for late-onset AD, but that the APP gene cannot be ruled out as a risk locus in those sibships without an E4 allele.
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Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.
Danielle M. Dick,Jacquelyn L. Meyers,Fazil Aliev,John I. Nurnberger,John Kramer,Samuel Kuperman,Bernice Porjesz,Jay A. Tischfield,Howard J. Edenberg,Tatiana Foroud,Marc A. Schuckit,Alison Goate,Victor Hesselbrock,Laura J. Bierut +13 more
TL;DR: Evidence is found of association with the combined AD with CD or SUI phenotype, with 23 genes surviving permutation testing, which may explain the persistent linkage findings reported on chromosome 2 across a number of independent studies of alcohol and disinhibitory phenotypes.
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Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease
Victoria L. Busby,Steven Goossens,Petra Nowotny,Gillian Hamilton,Scott Smemo,Denise Harold,D. Turic,Luke Jehu,Amanda J. Myers,Meredith Womick,Daniel Woo,Danielle Compton,Lisa Doil,Kristina Tacey,Kit Lau,Safa Al-Saraj,Richard Killick,Stuart Pickering-Brown,Pamela Moore,Paul Hollingworth,Nicola Archer,Catherine Foy,Sarah Walter,C. Lendon,Takeshi Iwatsubo,John C. Morris,Joanne Norton,David M. A. Mann,Barbara Janssens,John Hardy,Michael Conlon O'Donovan,Lesley Jones,Julie Williams,Peter Holmans,Michael John Owen,Andrew Grupe,John Powell,Jolanda van Hengel,Alison Goate,Frans van Roy,Simon Lovestone +40 more
TL;DR: It is concluded that CTNNA3 is unlikely to account for the AD susceptibility locus on chromosome 10, and like other α-catenins, it inhibits Wnt signaling and is therefore also a functional candidate.
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A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains.
Patrick C.G. Haddick,Jessica L. Larson,Nisha Rathore,Tushar Bhangale,Qui T. Phung,Karpagam Srinivasan,David V. Hansen,Jennie R. Lill,Margaret A. Pericak-Vance,Jonathan L. Haines,Lindsay A. Farrer,John S. K. Kauwe,Gerard D. Schellenberg,Carlos Cruchaga,Alison Goate,Timothy W. Behrens,Ryan J. Watts,Robert R. Graham,Joshua S. Kaminker,Marcel P. van der Brug +19 more
TL;DR: The study suggests that a common coding region variant of the IL-6 receptor results in neuroinflammatory changes that may influence the age of onset of Alzheimer's disease in APOE ɛ4 carriers.
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Description of the Genetic Analysis Workshop 11 Collaborative Study on the Genetics of Alcoholism.
Henri Begleiter,Theodore Reich,John I. Nurnberger,Ting-Kai Li,P. M. Conneally,Howard J. Edenberg,Raymond R. Crowe,Samuel Kuperman,M. Schuckit,F. Bloom,Victor Hesselbrock,Bernice Porjesz,C. R. Cloninger,John P. Rice,Alison Goate +14 more
TL;DR: Problem 1 of Genetic Analysis Workshop 11 consists of data from a family study of the genetics of alcoholism and related traits contributed by the six centers making up the National Institute for Alcohol Abuse and Alcoholism sponsored by the Collaborative Study on the Genetics of Alcoholism (COGA).