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Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
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Genetic nurture effects for alcohol use disorder
Nathaniel Thomas,Jessica E. Salvatore,S. I-C. Kuo,Fazil Aliev,Vivia V. McCutcheon,Jacquelyn M. Meyers,Kathleen K. Bucholz,Sarah J. Brislin,Grace Chan,Howard J. Edenberg,Chella Kamarajan,John Kramer,Samuel Kuperman,Gayathri Pandey,Martin H. Plawecki,Marc A. Schuckit,Danielle M. Dick,Bernice Porjesz,Victor Hesselbrock,Tatiana Foroud,Arpana Agrawal,Yunlong Liu,Ashwini K. Pandey,L. Bierut,John P. Rice,Jay A. Tischfield,Ronald P. Hart,Laura Almasy,Alison Goate,Paul A. Slesinger,Denise M. Scott +30 more
TL;DR: For example, the authors found that exposure to parental relationship discord and parental divorce mediated the transmission of genetic risk for alcohol problems from parents to children to predict earlier ages regular drinking and intoxication.
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Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs
Elin S. Blom,Vilmantas Giedraitis,Sampath Arepalli,Marian L. Hamshere,Omanma Adighibe,Alison Goate,Julie Williams,Lars Lannfelt,John Hardy,Fabienne Wavrant-De Vrièze,Anna Glaser +10 more
TL;DR: The present investigation provides yet further evidence that 19q13 is the only chromosomal region consistently linked to Alzheimer's disease.
Journal ArticleDOI
The complex genetic architecture of Alzheimer's disease: novel insights and future directions
Shea J. Andrews,Alan E. Renton,Brian Fulton-Howard,Anna Podlesny-Drabiniok,Edoardo Marcora,Alison Goate +5 more
TL;DR: In this article , a genome-wide association study (GWAS) was conducted to expand the sample sizes and the number of disease susceptibility loci. But, the results of the GWAS showed that the heritability estimates from population based GWAS cohorts are markedly smaller than those from twin studies.
Journal ArticleDOI
Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers
Logan Brase,S.F. You,Ricardo D’Oliveira Albanus,Jorge L. Del-Aguila,Yaoyi Dai,B. Novotny,Carolina Soriano-Tárraga,Taitea Dykstra,Maria Victoria Fernandez,John P. Budde,Kristy Bergmann,John C. Morris,Randall J. Bateman,R. Perrino,Eric McDade,Chengjie Xiong,Alison Goate,Martin R. Farlow,Greg T. Sutherland,Jonathan Kipnis,Celeste M. Karch,Bruno A. Benitez,Oscar Harari +22 more
TL;DR: This paper performed single-nucleus RNA-sequencing (snRNA-seq) on nearly 300,000 nuclei from the parietal cortex of AD autosomal dominant (APP and PSEN1) and risk-modifying variant (APOE, TREM2 and MS4A) carriers.
Posted ContentDOI
Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer’s disease
Nisha Rathore,Sree R. Ramani,Homer Pantua,Jian Payandeh,Tushar Bhangale,Arthur Wuster,Manav Kapoor,Yonglian Sun,Sharookh B. Kapadia,Lino C. Gonzalez,Ali A. Zarrin,Alison Goate,David V. Hansen,Timothy W. Behrens,Robert R. Graham +14 more
TL;DR: It is proposed that PILRA G78R protects individuals from Alzheimer’s disease risk via reduced inhibitory signaling in microglia and reduced microglial infection during HSV-1 recurrence.