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Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
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Journal ArticleDOI
Alzheimer's disease untangled
Fiona Crawford,Alison Goate +1 more
TL;DR: The development of models of AD using the APP mutations offers the possibility of identifying drug targets and developing more effective treatments than are presently available, and the precise effects of these amino acid substitutions are not understood.
Posted ContentDOI
Integration of Alzheimer's disease genetics and myeloid genomics reveals novel disease risk mechanisms
Gloriia Novikova,Manav Kapoor,Julia Tcw,Edsel M. Abud,Anastasia G. Efthymiou,Haoxiang Cheng,John F. Fullard,Jaroslav Bendl,Panos Roussos,Wayne W. Poon,Ke Hao,Edoardo Marcora,Alison Goate +12 more
TL;DR: It is shown that AD risk alleles are specifically enriched in active enhancers of monocytes, macrophages and microglia, suggesting dysfunction of the myeloid endolysosomal system in the etiology of AD.
Journal ArticleDOI
A sex-adjusted and age-adjusted genome screen for nested alcohol dependence diagnoses.
Jonathan Corbett,Nancy L. Saccone,Tatiana Foroud,Alison Goate,Howard J. Edenberg,John I. Nurnberger,Bernice Porjesz,Henri Begleiter,Theodore Reich,John P. Rice +9 more
TL;DR: A sex-adjusted and age-adjusted multiple threshold liability model is used for linkage analyses of the trait of alcohol dependence using affected sib-pair methods with a dichotomous phenotype definition.
Journal ArticleDOI
Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network.
Celeste M. Karch,Damián Hernández,Jen Chyong Wang,Jacob A. Marsh,Alex W. Hewitt,Alex W. Hewitt,Simon Hsu,Joanne Norton,Denise Levitch,Tamara Donahue,Wendy Sigurdson,Bernardino Ghetti,Martin R. Farlow,Jasmeer P. Chhatwal,Sarah B. Berman,Carlos Cruchaga,John C. Morris,Randall J. Bateman,Alice Pébay,Alison Goate +19 more
TL;DR: A library of 98 dermal fibroblast lines from 42 ADAD families enrolled in the Dominantly Inherited Alzheimer Network (DIAN) is generated, representing a comprehensive resource that can be used for disease modeling and the development of novel therapeutics.
A genome-wide association study of alcohol
J. Bierut,Arpana Agrawal,Kathleen K. Bucholz,Kimberly F. Doheny,Cathy C. Laurie,Elizabeth W. Pugh,Sherri L. Fisher,Louis Fox,William Howells,Sarah Bertelsen,Anthony L. Hinrichs,Laura Almasy,Naomi Breslau,Robert Culverhouse,Danielle M. Dick,Howard J. Edenberg,Richard A. Grucza,Dorothy K. Hatsukami,Victor Hesselbrock,Eric O. Johnson,John Kramer,Robert F. Krueger,Michael T. Lynskey,Rosalind J. Neuman,Markus M. Nöthen,John I. Nurnberger,Monika Ridinger,Nancy L. Saccone,Scott F. Saccone,Marc A. Schuckit,Jay A. Tischfield,Jen C. Wang,Alison Goate,John P. Rice +33 more
TL;DR: Geneticinfluencesonal alcohol dependence was explored among 1,897 European-American and African-American subjects with alcohol dependence compared with 1,932unrelated, alcohol-exposed, nondependent controls.