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Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
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Journal ArticleDOI
A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence.
Laura J. Bierut,John P. Rice,Alison Goate,Anthony L. Hinrichs,Nancy L. Saccone,Tatiana Foroud,Howard J. Edenberg,C. Robert Cloninger,Henri Begleiter,P. Michael Conneally,Raymond R. Crowe,Victor Hesselbrock,Ting-Kai Li,John I. Nurnberger,Bernice Porjesz,Marc A. Schuckit,Theodore Reich +16 more
TL;DR: There is evidence of specific genetic regions involved in the development of habitual smoking and not alcohol dependence, and there is also evidence of an area on chromosome 2 that may reflect a common genetic vulnerability locus to both habitualsmoking and alcohol dependence.
Journal ArticleDOI
Missense variant in TREML2 protects against Alzheimer's disease
Bruno A. Benitez,Sheng Chih Jin,Rita Guerreiro,Rita Guerreiro,R. R. Graham,Jenny Lord,Denise Harold,Rebecca Sims,Jean-Charles Lambert,Jean-Charles Lambert,Jean-Charles Lambert,J. Raphael Gibbs,J. Raphael Gibbs,Jose Bras,Celeste Sassi,Celeste Sassi,Oscar Harari,Sarah Bertelsen,Michelle K. Lupton,John Powell,Céline Bellenguez,Céline Bellenguez,Céline Bellenguez,Kristelle Brown,Christopher Medway,Patrick C.G. Haddick,Marcel P. van der Brug,Tushar Bhangale,Ward Ortmann,Timothy W. Behrens,Richard Mayeux,Margaret A. Pericak-Vance,Margaret A. Pericak-Vance,Lindsay A. Farrer,Gerard D. Schellenberg,Jonathan L. Haines,Jim Turton,Anne Braae,Imelda Barber,Anne M. Fagan,David M. Holtzman,John C. Morris,Julie Williams,John S. K. Kauwe,Philippe Amouyel,Philippe Amouyel,Philippe Amouyel,Kevin Morgan,AB Singleton,John Hardy,Alison Goate,Carlos Cruchaga,Carlos Cruchaga +52 more
TL;DR: Complete analyses using whole-exome sequencing data, cerebrospinal fluid biomarker analyses, meta-analyses and cell-based functional studies support the role of the TREML2 coding missense variant p.R47H (rs3747742) as a potential driver of the meta-analysis AD-associated genome-wide association studies signal.
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A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death
Monica K Wetzel-Smith,Julie Hunkapiller,Tushar Bhangale,Karpagam Srinivasan,Janice A. Maloney,Jasvinder K. Atwal,Susan M Sa,Murat Yaylaoglu,Oded Foreman,Ward Ortmann,Nisha Rathore,David V. Hansen,Marc Tessier-Lavigne,Richard Mayeux,Margaret A. Pericak-Vance,Jonathan L. Haines,Lindsay A. Farrer,Gerard D. Schellenberg,Alison Goate,Timothy W. Behrens,Carlos Cruchaga,Ryan J. Watts,Robert R. Graham +22 more
TL;DR: It is proposed that one possible mechanism in which T835M UNC5C contributes to the risk of Alzheimer's disease is by increasing susceptibility to neuronal cell death, particularly in vulnerable regions of the Alzheimer's Disease brain.
Journal ArticleDOI
Contribution of APOE promoter polymorphisms to Alzheimer's disease risk.
Jean-Charles Lambert,L. Araria-Goumidi,L. Myllykangas,C. Ellis,J. C. Wang,María J. Bullido,J. M. Harris,M. J. Artiga,D. Hernandez,J. M. Kwon,Bernard Frigard,R. C. Petersen,A. M. Cumming,Florence Pasquier,I. Sastre,P. J. Tienari,A. Frank,R. Sulkava,John C. Morris,D. St. Clair,D M Mann,F. Wavrant-DeVrièze,M. Ezquerra-Trabalon,P. Amouyel,John Hardy,M. Haltia,F. Valdivieso,Alison Goate,Jordi Pérez-Tur,C. L. Lendon,Marie-Christine Chartier-Harlin +30 more
TL;DR: The results suggest that APOE expression is an important determinant of AD pathogenesis, with age accentuating the effect of the −219 TT genotype.
Journal ArticleDOI
Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation.
John S. K. Kauwe,Matthew H. Bailey,Perry G. Ridge,Rachel Perry,Mark E. Wadsworth,Kaitlyn L. Hoyt,Lyndsay A. Staley,Celeste M. Karch,Oscar Harari,Carlos Cruchaga,Benjamin J. Ainscough,Kelly R. Bales,Eve H. Pickering,Sarah Bertelsen,Anne M. Fagan,Holtzman David M,John C. Morris,Alison Goate +17 more
TL;DR: The genetic associations reported here are novel and suggest mechanisms for genetic control of CSF and plasma levels of these disease-related proteins/pathways may be valuable therapeutic targets for AD.