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Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
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Journal ArticleDOI
Functional Connectivity in Autosomal Dominant and Late-Onset Alzheimer Disease
Jewell B. Thomas,Matthew R. Brier,Randall J. Bateman,Abraham Z. Snyder,Tammie L.S. Benzinger,Chengjie Xiong,Marcus E. Raichle,David M. Holtzman,Reisa A. Sperling,Richard Mayeux,Bernardino Ghetti,John M. Ringman,Stephen Salloway,Eric McDade,Martin N. Rossor,Sebastien Ourselin,Peter R. Schofield,Peter R. Schofield,Colin L. Masters,Ralph N. Martins,Michael W. Weiner,Paul M. Thompson,Nick C. Fox,Robert A. Koeppe,Clifford R. Jack,Chester A. Mathis,Angela Oliver,Tyler Blazey,Krista L. Moulder,Virginia Buckles,Russ C. Hornbeck,Jasmeer P. Chhatwal,Aaron P. Schultz,Alison Goate,Anne M. Fagan,Nigel J. Cairns,Daniel S. Marcus,John C. Morris,Beau M. Ances +38 more
TL;DR: Ordinal logistic regression models constructed in one type of Alzheimer disease accurately predicted clinical dementia rating scores in the other, further demonstrating the similarity of functional connectivity loss in each disease type.
Journal ArticleDOI
Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease
Richard Abraham,Amanda J. Myers,Fabienne Wavrant-DeVrieze,Marian L. Hamshere,Hollie Victoria Thomas,Helen Marshall,Danielle Compton,Gillian Spurlock,D. Turic,Bastiaan Hoogendoorn,Jennifer M. Kwon,Ronald C. Petersen,Eric G. Tangalos,Joanne Norton,John C. Morris,Roger Bullock,D Liolitsa,Simon Lovestone,John Hardy,Alison Goate,Michael Conlon O'Donovan,Julie Williams,Michael John Owen,Lesley Jones +23 more
TL;DR: Insulin-degrading enzyme (IDE) does not make a substantial contribution to the aetiology of LOAD and therefore cannot account for the linkage between LoAD and 10q.
Journal ArticleDOI
Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci.
TL;DR: Findings together with the function of PILRB as a DAP12 receptor supports the critical role of microglia and neuroinflammation in AD risk and demonstrates that PIL RB, as well as other genes within the GWAS loci, are most highly expressed inmicroglia.
Journal ArticleDOI
Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples.
Scott F. Saccone,Michele L. Pergadia,Anu Loukola,Ulla Broms,Grant W. Montgomery,Jen C. Wang,Arpana Agrawal,Danielle M. Dick,Andrew C. Heath,Alexandre A. Todorov,Heidi Maunu,Kauko Heikkilä,Katherine I. Morley,Katherine I. Morley,John P. Rice,Richard D. Todd,Jaakko Kaprio,Leena Peltonen,Nicholas G. Martin,Alison Goate,Pamela A. F. Madden +20 more
TL;DR: A genomewide linkage screen of a simple heavy-smoking quantitative trait, the maximum number of cigarettes smoked in a 24-h period, using two independent samples, may reveal variants contributing to heaviness of smoking, which will lead to a better understanding of the genetic mechanisms underlying nicotine dependence.
Journal ArticleDOI
Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes.
Gloriia Novikova,Manav Kapoor,Julia Tcw,Edsel M. Abud,Anastasia G. Efthymiou,Steven X. Chen,Haoxiang Cheng,John F. Fullard,Jaroslav Bendl,Yiyuan Liu,Panos Roussos,Johan L.M. Björkegren,Johan L.M. Björkegren,Yunlong Liu,Wayne W. Poon,Ke Hao,Edoardo Marcora,Alison Goate +17 more
TL;DR: In this article, the authors integrated Alzheimer's disease (AD) GWAS data with myeloid cell genomics, and reported that myELoid active enhancers are most burdened by AD risk alleles.