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Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
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Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes.
Janet Cady,Peggy Allred,Taha Bali,Alan Pestronk,Alison Goate,Timothy M. Miller,Robi D. Mitra,John Ravits,Matthew B. Harms,Robert H. Baloh +9 more
TL;DR: In this paper, targeted pooled-sample sequencing was used to identify variants in 17 known ALS genes and assess the contribution of possible oligogenic inheritance in 391 ALS patients from the United States.
A Quantitative-Trait Genome-Wide Association Study of Alcoholism Risk in the Community: Findings and
Implications C. Heath,John Whitfield,Nicholas G. Martin,Michele L. Pergadia,Alison Goate,Penelope A. Lind,Brian P. McEvoy,Andrew J. Schrage,Julia D. Grant,Yi-Ling Chou,Rachel Zhu,Anjali K. Henders,Sarah E. Medland,Scott D. Gordon,Elliot C. Nelson,Arpana Agrawal,Dale R. Nyholt,Kathleen K. Bucholz,Grant W. Montgomery +18 more
TL;DR: For example, the authors found that small effect sizes for individual SNPs suggest that hundreds of genetic variants make modest contributions (1/4% of variance or less) to alcohol dependence risk.
Journal ArticleDOI
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease
Andrew Grupe,Yonghong Li,Charles M. Rowland,Petra Nowotny,Anthony L. Hinrichs,Scott Smemo,John S. K. Kauwe,Taylor J. Maxwell,Sara Cherny,Lisa Doil,Kristina Tacey,Ryan van Luchene,Amanda J. Myers,Fabienne Wavrant-De Vrièze,Mona Kaleem,Paul Hollingworth,Luke Jehu,Catherine Foy,Nicola Archer,Gillian Hamilton,Peter Holmans,Christopher Morris,Joseph J. Catanese,John J. Sninsky,Thomas J. White,John Powell,John Hardy,Michael Conlon O'Donovan,Simon Lovestone,Lesley Jones,John C. Morris,Leon J. Thal,Michael John Owen,Julie Williams,Alison Goate +34 more
TL;DR: Results indicate that variants in the RPS3A homologue are associated with LOAD and implicate this gene, adjacent genes, or other functional variants (e.g., noncoding RNAs) in the pathogenesis of this disorder.
Journal ArticleDOI
Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery
Henry A. Lester,Cheng Xiao,Rahul Srinivasan,Cagdas D Son,Julie M. Miwa,Rigo Pantoja,Matthew R. Banghart,Dennis A. Dougherty,Alison Goate,Jen C. Wang +9 more
TL;DR: It is hypothesized that SePhaChARNS underlies classical observations that chronic exposure to nicotine causes “upregulation” of nicotinic receptors (nAChRs) and may underlie two inadvertent therapeutic effects of tobacco use.
Journal ArticleDOI
Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease
Mike Hutton,F. Busfield,Michelle Wragg,Richard Crook,Jordi Pérez-Tur,Robert Clark,G. Prihar,C. Conover Talbot,Phillips H,Kristal Wright,Matt Baker,C. Lendon,Karen Duff,Alonso Martínez,H. Houlden,Nichols A,Eric Karran,G.W. Roberts,P Roques,Martin N. Rossor,Venter Jc,Adams,Cline Rt,Phillips Ca,Alison Goate +24 more
TL;DR: The intron/exon structure of the gene is elucidated and intronic primers are designed to enable direct sequencing of the entire coding region (10 exons) of the presenilin gene in a large number of families.