A
Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
Papers
More filters
Journal ArticleDOI
A Systematic Single Nucleotide Polymorphism Screen to Fine-Map Alcohol Dependence Genes on Chromosome 7 Identifies Association With a Novel Susceptibility Gene ACN9
Danielle M. Dick,Fazil Aliev,Jen C. Wang,Scott F. Saccone,Anthony L. Hinrichs,Sarah Bertelsen,John P. Budde,Nancy L. Saccone,Tatiana Foroud,John I. Nurnberger,Xiaoling Xuei,P. M. Conneally,Marc A. Schuckit,Laura Almasy,Raymond R. Crowe,Samuel Kuperman,John Kramer,Jay A. Tischfield,Victor Hesselbrock,Howard J. Edenberg,Bernice Porjesz,John P. Rice,Laura J. Bierut,Alison Goate +23 more
TL;DR: Single nucleotide polymorphisms screened across a 2 LOD support interval surrounding the alcohol dependence peak suggest that ACN9 is involved in the predisposition to alcohol dependence and data from yeast suggest thatACN9 are involved in gluconeogenesis and the assimilation of ethanol or acetate into carbohydrate.
Journal ArticleDOI
ABCA7 p.G215S as potential protective factor for Alzheimer's disease
Celeste Sassi,Mike A. Nalls,Perry G. Ridge,J. R. Gibbs,Jinhui Ding,Michelle K. Lupton,Claire Troakes,Katie Lunnon,Safa Al-Sarraj,Kristelle Brown,Christopher Medway,Naomi Clement,Jenny Lord,James Turton,Jose Bras,Maria Rosário Almeida,Henne Holstege,Eva Louwersheimer,Wiesje M. van der Flier,Philip Scheltens,John C. van Swieten,Isabel Santana,Catarina R. Oliveira,Kevin Morgan,John Powell,John S. K. Kauwe,Carlos Cruchaga,Alison Goate,Andrew B. Singleton,Rita Guerreiro,John Hardy +30 more
TL;DR: The role of ABCA7 in AD is confirmed and provides new insights that should address functional studies, and the single independent and joint effect of rare and low-frequency protein coding variants in 9 AD GWAS loci with the strongest effect sizes are analyzed.
Association of substance dependence phenotypes in the COGA sample
Leah Wetherill,Arpana Agrawal,Manav Kapoor,Sarah Bertelsen,Laura J. Bierut,Andrew Brooks,Danielle M. Dick,Michie Hesselbrock,Victor Hesselbrock,Daniel L. Koller,Nhung Le,John I. Nurnberger,Jessica E. Salvatore,Marc A. Schuckit,Jay A. Tischfield,Jen Chyong Wang,Xiaoling Xuei,Howard J. Edenberg,Bernice Porjesz,Kathleen K. Bucholz,Alison Goate,Tatiana Foroud +21 more
TL;DR: In this paper, the authors conducted a genome-wide association analysis of a binary and a continuous index of general substance dependence liability, based on meeting lifetime criteria for any DSM-IV dependence on alcohol, cannabis, cocaine or opioids.
Journal ArticleDOI
Genome-wide association study identifies a novel locus for cannabis dependence.
Arpana Agrawal,Yi-Ling Chou,Caitlin E. Carey,David A.A. Baranger,Bo Zhang,Richard Sherva,Leah Wetherill,Manav Kapoor,J. C. Wang,Sarah Bertelsen,Andrey P. Anokhin,Victor Hesselbrock,John Kramer,Michael T. Lynskey,Jacquelyn L. Meyers,John I. Nurnberger,John P. Rice,Jay A. Tischfield,Laura J. Bierut,Louisa Degenhardt,Lindsay A. Farrer,Joel Gelernter,Joel Gelernter,Ahmad R. Hariri,Andrew C. Heath,Henry R. Kranzler,Pamela A. F. Madden,Nicholas G. Martin,Grant W. Montgomery,Bernice Porjesz,Ting Wang,John Whitfield,Howard J. Edenberg,Howard J. Edenberg,Tatiana Foroud,Alison Goate,Ryan Bogdan,Elliot C. Nelson +37 more
TL;DR: The identification and characterization of genome-wide significant loci for cannabis dependence is among the first steps toward understanding the biological contributions to the etiology of this psychiatric disorder, which appears to be rising in some developed nations.
Journal ArticleDOI
Calcium phosphatase calcineurin influences tau metabolism.
TL;DR: It is demonstrated that calcineurin protein levels are inversely correlated with dementia severity and Braak tangle stage in AD brains, and calcineURin activity is globally reduced inAD brains.