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Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
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Journal ArticleDOI
Copy Number Variations in 6q14.1 and 5q13.2 are Associated with Alcohol Dependence
Peng Lin,Sarah M. Hartz,Jen Chyong Wang,Arpana Agrawal,Tianxiao Zhang,Nicholas P. McKenna,Kathleen K. Bucholz,Andrew Brooks,Jay A. Tischfield,Howard J. Edenberg,Victor Hesselbrock,John Kramer,Samuel Kuperman,Marc A. Schuckit,Alison Goate,Laura J. Bierut,John P. Rice +16 more
TL;DR: This is the first study to show an association between DSM-IV alcohol dependence and CNVs, andCNVs in regions previously associated with neurological disorders may be associated with alcohol dependence.
Journal ArticleDOI
Characterization of N-terminal processing of group VIA phospholipase A2 and of potential cleavage sites of amyloid precursor protein constructs by automated identification of signature peptides in LC/MS/MS analyses of proteolytic digests.
Haowei Song,Silva Hećimović,Alison Goate,Fong-Fu Hsu,Shunzhong Bao,Ilan Vidavsky,Sasanka Ramanadham,John Turk +7 more
TL;DR: A Signature-Discovery program to characterize protein isoforms by identifying signature peptides that arise from proteolytic processing in vivo is developed and applied to the identification of variants of proteins of biological interest, including APP cleavage products and iPLA2β.
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A polymorphism in the presenilin 1 gene does not modify risk for Alzheimer's disease in a cohort with sporadic early onset
TL;DR: It is reported that homozygosity for the 'T' allele of a polymorphism in the presenilin 1 gene does not incur risk in a case control sample of early onset Alzheimer's disease, possibly suggesting a different disease etiology between the early and late onset forms.
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Variant-dependent heterogeneity in amyloid β burden in autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analyses of an observational study
Jasmeer P. Chhatwal,Stephanie A. Schultz,Eric McDade,L. Schultz,Lei Liu,Bernard Hanseeuw,Nelly Joseph-Mathurin,Rebecca L. Feldman,Colleen D. Fitzpatrick,Kathryn P. Sparks,Johannes Levin,Sarah B. Berman,Alan E. Renton,Bianca Esposito,Maria Victoria Fernandez,Yun Ju Sung,Jae-Hong Lee,William E. Klunk,Anna Hofmann,James M. Noble,Neill R. Graff-Radford,Hiroshi Mori,Stephen Salloway,Colin L. Masters,Ralph N. Martins,Celeste M. Karch,Chengjie Xiong,Carlos Cruchaga,R. Perrino,Brian A. Gordon,Tammie L.S. Benzinger,Nick C. Fox,Peter R. Schofield,Anne M. Fagan,Alison Goate,John C. Morris,Randall J. Bateman,Keith A. Johnson,Reisa A. Sperling +38 more
TL;DR: The results suggest that CSF and PET measures of Aβ levels are not interchangeable and might reflect different Aβ-driven pathobiological processes, and that higher levels of PiB-PET signal at an individual level might not reflect more severe or more advanced disease.
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Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults
David B. Chorlian,Madhavi Rangaswamy,Niklas Manz,Jen Chyong Wang,Danielle M. Dick,Laura Almasy,Lance O. Bauer,Kathleen K. Bucholz,Tatiana Foroud,Victor Hesselbrock,Sun J. Kang,John Kramer,Samuel Kuperman,John I. Nurnberger,John P. Rice,Marc A. Schuckit,Jay A. Tischfield,Howard J. Edenberg,Alison Goate,Laura J. Bierut,Bernice Porjesz +20 more
TL;DR: The age specificity of the genetic and neurophysiological factors is consistent with recent studies of adolescent brain development, which locate an interval of heightened vulnerability to substance use disorders in the early to mid teens.