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Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
Papers
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Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease
Nelly Joseph-Mathurin,Yi Su,Tyler Blazey,Mateusz S. Jasielec,Andrei G. Vlassenko,Karl A. Friedrichsen,Brian A. Gordon,Russ C. Hornbeck,Lisa Cash,Beau M. Ances,Thomas Veale,David M. Cash,Adam M. Brickman,Virginia Buckles,Nigel J. Cairns,Carlos Cruchaga,Alison Goate,Clifford R. Jack,Celeste M. Karch,William E. Klunk,Robert A. Koeppe,Daniel S. Marcus,Richard Mayeux,Eric McDade,James M. Noble,John M. Ringman,Andrew J. Saykin,Paul M. Thompson,Chengjie Xiong,John C. Morris,Randall J. Bateman,Tammie L.S. Benzinger +31 more
TL;DR: The utility of dynamic PET measures of perfusion using 11C‐Pittsburgh compound B (PiB) to estimate neuronal injury in comparison to FDG PET is evaluated.
Journal ArticleDOI
Genetic characterization of a novel familial dementia.
Jeremy P Brown,Simon Smith,A Brun,A Brun,John Collinge,Susanne Gydesen,John Hardy,Michael Mullan,Alison Goate +8 more
TL;DR: Genetic findings from this family in which linkage analysis has excluded Huntington's disease and chromosome 21-encoded Alzheimer's disease are presented, which probably represents a novel genetic dementia.
Journal ArticleDOI
Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer's disease: Associations with Aβ-PET, neurodegeneration, and cognition.
Pratishtha Chatterjee,Lisa Vermunt,Brian A. Gordon,Steve Pedrini,Lynn Boonkamp,Nicola J. Armstrong,Chengjie Xiong,Abhay K. Singh,Yan Li,Hamid R. Sohrabi,Kevin Taddei,Mark P. Molloy,Tammie L.S. Benzinger,John C. Morris,Celeste M. Karch,Sarah B. Berman,Jasmeer P. Chhatwal,Carlos Cruchaga,Neill R. Graff-Radford,Gregory S. Day,Martin R. Farlow,Nick C. Fox,Alison Goate,Jason Hassenstab,Jae-Hong Lee,Johannes Levin,Eric McDade,Hiroshi Mori,R. Perrino,Raquel Sánchez-Valle,Peter R. Schofield,Allan I. Levey,Mathias Jucker,Colin L. Masters,Anne M. Fagan,Randall J. Bateman,Ralph N. Martins,Charlotte E. Teunissen +37 more
TL;DR: This paper found that GFAP elevations appear a decade before expected symptom onset, after amyloid beta (Aβ) accumulation and prior to neurodegeneration and cognitive decline.
Patent
Transgenic mouse expressing an APP-FAD DNA sequence
John Hardy,Marie-Christine Chartier-Harlin,Alison Goate,Michael John Owen,Michael John Mullan +4 more
TL;DR: In this paper, a model system of Alzheimer's disease comprises a DNA sequence encoding an amyloid precursor protein (APP) isoform or fragment that has an amino acid substitution.
Genome-wide association study identifies loci associated with liability to alcohol and drug dependence that is associated with variability in reward-related ventral striatum activity in African- and European-Americans
Leah Wetherill,Dongbing Lai,Emma C. Johnson,Andrey P. Anokhin,Lance O. Bauer,Kathleen K. Bucholz,Danielle M. Dick,Ahmad R. Hariri,Victor Hesselbrock,Chella Kamarajan,John Kramer,Samuel Kuperman,Jacquelyn L. Meyers,John I. Nurnberger,Marc A. Schuckit,Denise M. Scott,Robert E. Taylor,Jay A. Tischfield,Bernice Porjesz,Alison Goate,Howard J. Edenberg,Tatiana Foroud,Ryan Bogdan,Arpana Agrawal +23 more
TL;DR: This article conducted a genome-wide association study (GWAS) of a phenotype representing alcohol or illicit drug dependence (anyDEP) among 7291 European-Americans and 3132 African-Americans participating in the family-based Collaborative Study on the Genetics of Alcoholism.