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Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
Papers
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Journal ArticleDOI
Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6).
Li-Shiun Chen,A. Joseph Bloom,Timothy B. Baker,Stevens S. Smith,Megan E. Piper,Maribel Martinez,Nancy L. Saccone,Dorothy K. Hatsukami,Alison Goate,Laura J. Bierut +9 more
TL;DR: Nicotine replacement therapy is effective among individuals with fast, but not slow, CYP2A6-defined nicotine metabolism, and the effect of bupropion on relapse likelihood is unlikely to be affected by nicotine metabolism as estimated from CYP1A6 genotype.
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Stress–response pathways are altered in the hippocampus of chronic alcoholics
Jeanette N. McClintick,Xiaoling Xuei,Jay A. Tischfield,Alison Goate,Tatiana Foroud,Leah Wetherill,Leah Wetherill,Marissa A. Ehringer,Howard J. Edenberg +8 more
TL;DR: For example, this paper identified 639 genes whose expression significantly differed between alcoholics and controls at a False Discovery Rate (FDR) ≤ 0.20; 52% of these genes differed by at least 1.2-fold.
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E280A PS-1 mutation causes Alzheimer's disease but age of onset is not modified by ApoE alleles
Corinne Lendon,Alonso Martínez,Alonso Martínez,Isabel Maria Behrens,Kenneth S. Kosik,Lucia Madrigal,Joanne Norton,Rosalind J. Neuman,Amanda J. Myers,Frances Busfield,Michelle Wragg,M. Arcos,Juan Carlos Arango Viana,Jorge Ossa,Andrés Ruiz,Alison Goate,Francisco Lopera +16 more
TL;DR: The presence of a single mutation and the common geographic origin, with all families from the state of Antioquia, suggest a founder effect in this population of early‐onset Alzheimer's disease cases, supported by the observation of a rare haplotype inherited with AD in all kindreds.
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Extreme cerebrospinal fluid amyloid β levels identify family with late-onset Alzheimer's disease presenilin 1 mutation
John S. K. Kauwe,Sarah Jacquart,Sumi Chakraverty,Jun Wang,Kevin Mayo,Anne M. Fagan,David M. Holtzman,John C. Morris,Alison Goate +8 more
TL;DR: DNA sequence variation in the presenilin (PSEN1) gene is investigated using CSF Aβ levels as an endophenotype for Alzheimer's disease.
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Screening for mutations in the open reading frame and promoter of the β-amyloid precursor protein gene in familial Alzheimer's disease: identification of a further family with APP717 Val→lle
Liana Fidani,Karen Rooke,Marie-Christine Chartier-Harlin,David J. Hughes,Rudi Tanzi,Michael John Mullan,Michael John Mullan,P Roques,Martin N. Rossor,John Hardy,John Hardy,Alison Goate +11 more
TL;DR: The data suggest that mutations in APP are a rare cause of familial early onset AD and that within APP most, possibly all, mutations which cause AD are in exon 17.