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Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
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Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease.
Nisha Rathore,Sree R. Ramani,Homer Pantua,Jian Payandeh,Tushar Bhangale,Arthur Wuster,Manav Kapoor,Yonglian Sun,Sharookh B. Kapadia,Lino C. Gonzalez,Ali A. Zarrin,Alison Goate,David V. Hansen,Timothy W. Behrens,Robert R. Graham +14 more
TL;DR: It is proposed that PILRA G78R protects individuals from Alzheimer’s disease risk via reduced inhibitory signaling in microglia and reduced microglial infection during HSV-1 recurrence.
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An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project
Arpana Agrawal,Michele L. Pergadia,Scott F. Saccone,Michael T. Lynskey,Jen C. Wang,Nicholas G. Martin,Dixie J. Statham,Anjali K. Henders,Megan Campbell,Robertino Garcia,Ulla Broms,Richard D. Todd,Alison Goate,John P. Rice,Jaakko Kaprio,Andrew C. Heath,Grant W. Montgomery,Pamela A. F. Madden +17 more
TL;DR: A novel quantitative phenotype, a cannabis problems factor score composed of DSM-IV abuse and dependence criteria, is introduced that may be useful for future linkage and association studies.
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Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria
Dongbing Lai,Leah Wetherill,Sarah Bertelsen,Caitlin E. Carey,Chella Kamarajan,Manav Kapoor,Jacquelyn L. Meyers,Andrey P. Anokhin,David A. Bennett,Kathleen K. Bucholz,Katharine Chang,Philip L. De Jager,Danielle M. Dick,Victor Hesselbrock,John Kramer,Samuel Kuperman,John I. Nurnberger,Towfique Raj,Marc A. Schuckit,Denise M. Scott,Robert E. Taylor,Jay A. Tischfield,Ahmad R. Hariri,Howard J. Edenberg,Arpana Agrawal,Ryan Bogdan,Bernice Porjesz,Alison Goate,Tatiana Foroud +28 more
TL;DR: It is suggested that studying individual criteria may unveil new insights into the genetic etiology of AD liability, andPolygenic risk scores derived from the EA GWAS of AD predicted AD in two EA datasets (P < .01; 0.82% of variance).
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Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis.
Paul Hollingworth,Marian L. Hamshere,Peter Holmans,Michael Conlon O'Donovan,Rebecca Sims,John Powell,Simon Lovestone,Amanda J. Myers,Fabienne Wavrant DeVrieze,John Hardy,Alison Goate,Michael John Owen,Julie Williams +12 more
TL;DR: The hypothesis that psychotic symptoms in AD are genetically modified and that a gene/s implicated in their aetiology may be located on chromosome 7 and 15 is supported.
Journal ArticleDOI
Interplay of genetic risk factors and parent monitoring in risk for nicotine dependence
Li-Shiun Chen,Eric O. Johnson,Naomi Breslau,Dorothy K. Hatsukami,Nancy L. Saccone,Richard A. Grucza,Jen C. Wang,Anthony L. Hinrichs,Louis Fox,Alison Goate,John P. Rice,Laura J. Bierut +11 more
TL;DR: The genetic risk of nicotine dependent associated with rs16969968 was modified by level of parent monitoring, while the genetic risk associated withrs3743078 was not, suggesting that the increased risk due to some genes may be mitigated by environmental factors such as parent monitoring.